A Pilot Study to Evaluate Multi-Spectral and Laser Speckle Imaging and Multiphoton Microscopy During Vascular Occlusion

Last updated: March 25, 2025
Sponsor: University of California, Irvine
Overall Status: Active - Recruiting

Phase

N/A

Condition

N/A

Treatment

Multi-Spectral and Laser Speckle Imaging

Clinical Study ID

NCT01484730
20118370
  • Ages > 18
  • All Genders
  • Accepts Healthy Volunteers

Study Summary

The purpose of this research is to evaluate and validate the performance of non-invasive imaging modalities for assessment of skin. A pressure cuff occlusion will be used to stimulate blood flow dynamic that these instruments are designed to sense. The researcher currently plan to assess only basic feasibility of the imaging instruments.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Male and female adult 18 years and older

Exclusion

Exclusion Criteria:

  • Younger than 18 years of age

  • Pregnant women

Study Design

Total Participants: 150
Treatment Group(s): 1
Primary Treatment: Multi-Spectral and Laser Speckle Imaging
Phase:
Study Start date:
November 01, 2011
Estimated Completion Date:
August 31, 2026

Study Description

The primary reason for including pressure cuff occlusion in this protocol is to test the performance of Multi-Spectral Imaging and Laser Speckle Imaging can measure in the full range of vascular conditions ranging from ischemic (under-perfused or unsaturated) to hyperemic (over-perfused and over-saturated).

  1. Modulated Imaging a non-contact optical imaging technology can detect the concentration of total hemoglobin, deoxygenated and oxygenated hemoglobin in absolute amounts in units of millimoles / unit volume of tissue measured.

  2. Laser Speckle Imaging a non-contact optical imaging technology consists of a coherent light source, camera, and image acquisition system. This image device can measure and compare relative flow in vasculature at varied time points.

Connect with a study center

  • Beckman Laser Institute and Medical Clinic

    Irvine, California 92612
    United States

    Active - Recruiting

  • Beckman Laser Institute, UCI

    Irvine, California 92612
    United States

    Site Not Available

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