Enteral Nutrition as Stress Ulcer Prophylaxis in Critically Ill Patients.

Last updated: December 14, 2017
Sponsor: Mohamed Saad
Overall Status: Completed

Phase

N/A

Condition

Clostridium Difficile-associated Diarrhea

Hemorrhage

Ulcers

Treatment

N/A

Clinical Study ID

NCT01477320
11.0170
  • Ages > 18
  • All Genders

Study Summary

study is to determine if proton pump inhibitors plus enteral nutrition is superior to enteral nutrition alone as a stress ulcer prophylaxis strategy in critically ill patients in terms of incidence of overt and significant GI bleeding related to stress gastropathy.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Age 18 years or older

  • Admission to the medical ICU at University of Louisville Hospital or Jewish Hospital

  • Expected need for mechanical ventilation > 48 hours

  • No contraindication to EN within the first 24 hours after admission to the ICU

Exclusion

Exclusion Criteria:

  • Evidence of active GI bleeding during current hospitalization prior to study entry

  • Admission to ICU with primary diagnosis of burn injury

  • Closed head injury or increased intracranial pressure

  • Partial or complete gastrectomy

  • Pregnancy or lactation

Study Design

Total Participants: 124
Study Start date:
September 01, 2013
Estimated Completion Date:
July 31, 2016

Connect with a study center

  • University of Louisville hospital

    Louisville, Kentucky 40202
    United States

    Site Not Available

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