Efficacy and Safety Study of Total Flavonoids of Propolis Dropping Pill to Treat Angina Pectoris

Inclusion Criteria:

• Class I, Class II and Class III stable angina pectoris, angina attack more than 3times one week;

• Qi deficiency and blood stasis syndrome of Traditional Chinese Medicine;

• In resting electrocardiogram, ST-segment deviation≥0.05mv and/or T-waveinversion≥0.2mv in the leads R-wave is predominant during non-attack period, orST-segment deviation≥0.1mv and/or T-wave inversion≥0.2mv in the leads R-wave ispredominant during angina attack;

• Total exercise time of treadmill exercise test≥3 minutes.The discontinuance standardshould be reached. And the difference of total exercise time between before and afterrun in period should ≤15%;

• Other confirmed diagnostic evidence of coronary heart disease, such as definitehistory of old myocardial infarction, or incomplete revascularization one year aftercoronary intervention therapy(residual luminal stenosis≥50%), or coronary angiographyevidence(at least single vessel disease and luminal stenosis≥50%), or nucleinexamination evidence, or computer tomography angiography evidence;

• Signed the informed consent form.

Exclusion Criteria:

• Chest pain caused by acute myocardial infarction(AMI), Class IV/serious anginapectoris, psychosis, serious neurosis, climacteric syndrome, hyperthyroidism, CervicalSpondylosis, gallbladder- heart syndrome, gastroesophageal reflux, hiatus hernia,aortic dissection, aortic valve disease;

• Not well controlled hypertension(systolic pressure≥160mmHg，diastolicpressure≥100mmHg), serious cardiopulmonary insufficiency, serious arrhythmia(rapidatrial fibrillation, atrial flutter, paroxysmal ventricular tachycardia, etc);

• Serious diseases of heart, lung, liver, kidney and blood;

• Allergic constitution or allergic to the components of total Flavonoids of Propolisdropping pill;

• Women during pregnancy or lactation;

• Received any major operation within 4 weeks;

• Have been in other clinical trials within 30 days;

• Using but can not withdraw anti-angina medicine as long acting nitrates;

• Not well controlled hyperglycemia;

• Not fit for this trial judged by investigator.