SPD489 Adult Major Depressive Disorder (MDD) Open-label Safety and Tolerability Rollover Extension Study

Inclusion Criteria:

• Subject has completed 1 of the respective short-term antecedent SPD489 MDD studies anddid not experience any clinically significant AEs in the antecedent study that wouldpreclude exposure to SPD489.

Exclusion Criteria:

• Subject has any current co-morbid Axis I or Axis II psychiatric disorder (including alifetime history of psychosis) which was not present or recognized at entry into theantecedent study or has a concurrent chronic or acute illness or unstable medicalcondition that may deteriorate that could confound the results of safety assessments,increase risk to the subject or lead to difficulty complying with the protocol