The Health Effect of Diet Rich in Nordic Berries

Phase

N/A

Condition

Metabolic Syndrome

Diabetes (Pediatric)

Dyslipidemia

Treatment

N/A

Clinical Study ID

NCT01414647

124//2005

40361/05

Ages 50-65
All Genders
Accepts Healthy Volunteers

Study Summary

Dietary polyphenols might have beneficial effects on glucose and lipid metabolism based on the studies made in animals or cell cultures. The findings regarding the possible decrease of low-grade inflammation are existing also in humans. Low-grade inflammation has been suggested to be a mechanistic link between obesity and its consequences on cardiometabolic health. The aim of the present study is to examine the effect of diet rich in berries on glucose and lipid metabolism and inflammatory markers.

Eligibility Criteria

Inclusion

Inclusion Criteria:

overweight (BMI 26-39 kg/m2), and two of the following:
elevated fasting plasma glucose in the absence of diabetes (5.6-6.9 mmol/l)
abnormal serum lipid concentration: fasting serum triglyceride concentration >1.7mmol/L, fasting serum HDL cholesterol <1.0 mmol/L (males) or <1.3 mmol/L (females))
waist circumference >102 cm (males) or >88 cm (females)
blood pressure >130/85 mmHg

Exclusion

Exclusion Criteria:

chronic diseases
use of lipid lowering medication

Study Design

January 01, 2006

March 31, 2010

Study Description

Berries are traditionally an important part of the Nordic diet. About 50 different berries are grown in the northern region, and about half of them are edible. Phenolic compounds are one of the most diverse group of secondary metabolites present in edible plants, and berries are especially rich in them. Flavonoids, phenolic acids, lignans and complex phenolic polymers (polymeric tannins) are typical for berries. Phenolic compounds are reported to have a variety of beneficial biological properties. They are potent antioxidants, and exhibit various other physiological activities including anti-inflammatory, antimicrobial, antiallergic, anticarcinogenic and antihypertensive activities. Epidemiological studies indicate that diet rich in phenolic compound correlates with lower risk of cancer and cardiovascular disease.

The aim of the present study is to examine the effect of diet rich in berries on glucose and lipid metabolism and inflammatory markers and gene expression profile in peripheral blood mononuclear cells (PBMCs) in subjects with features of metabolic syndrome.

Randomized, controlled clinical intervention including 4 wk run-in period, 8 wk dietary intervention and 4 wk recovery period was conducted.

Connect with a study center

University of Eastern Finland, Dpet of Public Health and Clinical Nutrition
Kuopio, FIN-70211
Finland
Site Not Available

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