Respiratory and Physical Therapy in Patients With Associated Pulmonary Arterial Hypertension (APAH) With Congenital Heart Defects

Last updated: July 12, 2022
Sponsor: Heidelberg University
Overall Status: Active - Recruiting

Phase

N/A

Condition

Pulmonary Arterial Hypertension

Williams Syndrome

Stress

Treatment

N/A

Clinical Study ID

NCT01397110
2011-07-12
  • Ages 18-80
  • All Genders

Study Summary

The purpose of this study is to investigate the influence of physical training on exercise capacity, quality of life, functional class, oxygen consumption and right ventricular function in patients with severe associated pulmonary arterial hypertension (APAH) as part of a congenital heart defect with / without Eisenmenger's Syndrome

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • signed consent form
  • men and women> 18 years <80 years
  • APAH with congenital heart defects with / without Eisenmenger syndrome (WHO functionalclass II-IV), invasively diagnosed by right heart and left heart catheterization: meanpulmonary arterial pressure (mPAP) ≥ 25 mmHg, with targeted PAH medication for atleast two months stable before study inclusion (exception: compensated WHO class IIwithout vasodilating drug therapy)

Exclusion

Exclusion Criteria:

  • Pregnancy or lactation
  • Change in medication during the last 2 months
  • severe walking disturbance
  • uncertain diagnoses
  • No previous invasively confirmation of PH
  • acute diseases, infections, fever
  • Serious lung disease with FEV1 <50% or TLC <70% of target
  • Further exclusion criteria are the following diseases: active myocarditis, unstableangina pectoris, exercise-induced ventricular arrhythmias, recurrent syncope within 4weeks before study entry

Study Design

Total Participants: 50
Study Start date:
January 01, 2012
Estimated Completion Date:
December 31, 2025

Connect with a study center

  • : Center for pulmonary Hypertension, Thoraxclinic Heidelberg

    Heidelberg, 69126
    Germany

    Active - Recruiting

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