Study With Amitriptylin to Evaluate the Efficacy of Melatonin in Treatment of Migraine

Inclusion Criteria:

• Man or woman 18 to 65 years of age.

• Meets diagnostic criteria criteria of International Headache Society (IHS) 2004 (2)for migraine with and / or without aura.

• Frequency from 2 to 8 migraine attacks per month

• Top of crisis over a year and age of onset less than 50 years of age.

• Patients want to participate in the study, and able to give informed consent.

• If women, the patient must be willing to use an acceptable method of birth control (eg, a hormonal contraceptive, intrauterine device, diaphragm with spermicide orcondom with spermicide, or refer abstinence).

• Patient able and willing to remain on their medications throughout the study.

• Accept the guidelines of the study by filling out the diary and clinical scales.

Exclusion Criteria:

• Any medical condition that places the patient at risk with its exposure to melatoninor amitryptiline

• Use of alcohol and drugs.

• Be receiving prophylactic medication in the last three months.

• History of hemiplegic migraine, basilar, Ophthalmoplegic or stroke.

• Headache secondary to head trauma or a whiplash neck injury (whiplash).

• Pregnant or breastfeeding. Women planning to become pregnant or of childbearing agewithout acceptable method of contraception.

• Women who began taking oral contraceptives or who switched their oral contraceptiveregimen in the 6 months prior to the start of the study.

• Allergy or known hypersensitivity to study medication or its components.

• Participation in another clinical study one month before inclusion.