Phase 2 Pilot Study of the Safety and Efficacy of Topical MW-III in Thermal Burns

Last updated: November 4, 2025
Sponsor: Skingenix, Inc.
Overall Status: Active - Recruiting

Phase

2

Condition

Hyponatremia

Skin Wounds

Treatment

Silvadene® Cream 1% [Silver Sulfadiazine]

Investigational Drug, MW-III

Clinical Study ID

NCT01297400
MW-III-BURN-2-001
  • Ages > 18
  • All Genders

Study Summary

To compare MW-III to Silvadene® Cream 1% (Silver Sulfadiazine) with respect to "time to healing" (≥95% re-epithelialization) of a partial thickness target thermal burn.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  1. Adults, 18 years of age or older on the day of signing the informed consent.

  2. Thermal Burns not exceeding a total body surface area (TBSA) OF 25%, with at leastone partial thickness burn of 0.5% TBSA or greater. If full thickness burn(s) arepresent at screening, the total full thickness burn area shall not exceed 10% TBSA.Note: TBSA excludes areas of superficial (first degree) burns.

  3. Able and willing to give informed consent and comply with study procedures.

Exclusion

Exclusion Criteria:

  1. Any burn that at screening is:

  2. infected.

  3. circumferential or deemed, in the judgment of the investigator, at high riskfor developing compartment syndrome.

  4. partial thickness that is likely, in the judgment of the Investigator, torequire grafting within 72 hours, or other non-protocol intervention.

  5. Severe inhalation injury or other significant non-burn trauma.

Study Design

Total Participants: 60
Treatment Group(s): 2
Primary Treatment: Silvadene® Cream 1% [Silver Sulfadiazine]
Phase: 2
Study Start date:
March 11, 2022
Estimated Completion Date:
December 31, 2025

Study Description

This phase 2 pilot study will assess the safety and efficacy of topical MW-III on thermal burns.

Connect with a study center

  • Proactive CR Mexico SA de CV

    Irapuato 4004330,
    Mexico

    Active - Recruiting

  • SMIQ S de R. L de CV

    Querétaro City 3991164,
    Mexico

    Active - Recruiting

  • Valleywise Health Medical Center

    Phoenix, Arizona 85008
    United States

    Site Not Available

  • Valleywise Health Medical Center

    Phoenix 5308655, Arizona 5551752 85008
    United States

    Active - Recruiting

  • University of CA Davis Medical Center

    Sacramento, California 95817
    United States

    Site Not Available

  • University of CA Davis Medical Center

    Sacramento 5389489, California 5332921 95817
    United States

    Active - Recruiting

  • MedStar Washington Hospital Center

    Washington, District of Columbia 20010
    United States

    Site Not Available

  • MedStar Washington Hospital Center

    Washington D.C. 4140963, District of Columbia 4138106 20010
    United States

    Active - Recruiting

  • Joseph M. Still Burn Center, Doctor's Hospital

    Augusta, Georgia 30909
    United States

    Site Not Available

  • University of Iowa Health Care

    Iowa City, Iowa 52242
    United States

    Site Not Available

  • University of Iowa Health Care

    Iowa City 4862034, Iowa 4862182 52242
    United States

    Active - Recruiting

  • University Medical Center New Orleans

    New Orleans, Louisiana 70112
    United States

    Site Not Available

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