Study of Qiliqiangxin Capsule to Treat Dilated Cardiomyopathy

Last updated: August 26, 2017
Sponsor: Huazhong University of Science and Technology
Overall Status: Completed

Phase

4

Condition

Circulation Disorders

Heart Disease

Heart Failure

Treatment

N/A

Clinical Study ID

NCT01293903
QLQX-DCM-01
  • Ages 14-70
  • All Genders

Study Summary

The pathogenesis of dilated cardiomyopathy (DCM) leading to heart failure is closely associated with autoimmunity dysfunction. A few studies represented that Qiliqiangxin capsule, a Chinese medicine, could enhance heart function in chronic heart failure and regulate the balance of TNF-a and IL-10 in myocardial infarction. In this study, to explore the effects of Qiliqiangxin capsule on the improving heart function and immunoregulation in patients with DCM, patients were recruited, anti-heart autoantibodies and some representative cytokines were assayed by enzyme-linked immuno sorbent assay (ELISA), and the efficacy of heart function improvement was compared between Qiliqiangxin capsule and placebo under the standard treatment of DCM.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Dilated Cardiomyopathy (LVEF ≤ 45%)

Exclusion

Exclusion Criteria:

  • Secondary dilated cardiomyopathy (such as ischemic cardiomyopathy, valvularcardiomyopathy, hyperthyroid cardiomyopathy, diabetic cardiomyopathy, anemiacardiomyopathy, and etc.)

  • Coronary heart disease

  • Rheumatic heart disease

  • Pulmonary heart disease

  • Continuous dysarteriotony: hypertension(systolic blood pressure [SBP] ≥ 60mmHg/diastolic blood pressure [DBP] ≥ 100mmHg); hypotension(SBP < 90mmHg/DBP < 60mmHg)

  • Resting heart rate ≤ 50bpm

  • Atrioventricular block patients without permanent pacemaker

Study Design

Total Participants: 374
Study Start date:
January 01, 2012
Estimated Completion Date:
September 30, 2016

Connect with a study center

  • Union Hospital, Tongji Medical College, Huazhong University of Science and Technology

    Wuhan, Hubei 430022
    China

    Site Not Available

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