Effect of Fish Oil on Surgery Pain After Knee Replacement Patients: Randomized, Prospective, Double Blind, Placebo Control Trial

Last updated: November 21, 2013
Sponsor: Rabin Medical Center
Overall Status: Trial Status Unknown

Phase

N/A

Condition

Rheumatoid Arthritis

Dermatomyositis (Connective Tissue Disease)

Musculoskeletal Diseases

Treatment

N/A

Clinical Study ID

NCT01274910
5961
  • Ages 50-80
  • All Genders

Study Summary

This is a single-center, prospective, randomized, double blind, placebo control study. The aim of this study is to assess the effect of fish oil capsules on pain intensity and postoperative analgesics consumption in patients after knee replacement surgery.

The study population will be adult are referred for knee replacement surgery due to osteoarthritis of the knee.

Eligibility Criteria

Inclusion

Inclusion Criteria: Patients are referred for knee replacement surgery due to osteoarthritis of the knee

Exclusion

  • Exclusion Criteria:

  • Use of steroids, NSAIDs two weeks before surgery, antidepression drugs,antiepileptic drugs, coumadin

  • Diabetic neuropathy

  • Herpes-zoster/ post-herpetic neuralgia

  • n-3 supplements use

Study Design

Total Participants: 60
Study Start date:
January 01, 2011
Estimated Completion Date:
January 31, 2014

Study Description

Primary outcome:

Post surgical pain level and analgesics use

Secondary outcomes:

  1. Pain levels and analgesic use at six weeks and 3 months after surgery

  2. ω3 incorporation into blood cell membranes(RBC)

  3. Stress and inflammation markers

  4. Rates of postoperative complications

Study Procedure :

Enrolled patient will be randomly divided into a control group and intеrvention group during preoperative clinic visit. Each patient will receive total 150 capsules (5 capsules per day) accordingly to randomized group.

Patients in treatment group will receive Fish Oil capsules. Patients in control group will receive placebo capsules.

Connect with a study center

  • Rabin Medical Center, Campus Beilinson

    Petah Tikva, 49100
    Israel

    Active - Recruiting

Map preview placeholder

Not the study for you?

Let us help you find the best match. Sign up as a volunteer and receive email notifications when clinical trials are posted in the medical category of interest to you.