Evaluation of Exhaled Breath Condensate in the Diagnosis of Invasive Pulmonary Aspergillosis

Last updated: July 4, 2014
Sponsor: Universitaire Ziekenhuizen Leuven
Overall Status: Completed

Phase

N/A

Condition

Aspergillosis

Treatment

N/A

Clinical Study ID

NCT01247142
S52756
  • Ages > 16
  • All Genders
  • Accepts Healthy Volunteers

Study Summary

The purpose of this study is to evaluate the diagnostic potential of biomarkers for invasive pulmonary aspergillosis in exhaled breath condensate.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • hospitalisation in the hematology or intensive care department

  • age > 16 years

  • informed consent

  • proven or probable IPA (EORTC/ MSG criteria)

  • galactomannan positivity in BAL or serum

Exclusion

Exclusion Criteria:

  • age < 16 years

Study Design

Total Participants: 24
Study Start date:
January 01, 2011
Estimated Completion Date:
July 31, 2014

Study Description

Invasive pulmonary aspergillosis (IPA) is a life-threatening infection in immunocompromised patients. The poor prognosis of the disease is partly attributed to difficulties encountered with the diagnosis of this infection. Invasive sampling procedures are often precluded in these patients. In addition, conventional diagnostic techniques lack sensitivity. Recently there has been increasing interest in the investigation of the lungs by noninvasive means including measurement of biomarkers in exhaled breath (e.g. NO) and those found in the cooled and condensed exhalate,termed EBC. It has been demonstrated that a measurable fraction of the EBC in healthy subjects is derived from aerosolized airway lining fluid. The presence of biomarkers for IPA will be investigated in EBC of patients with IPA, compared to controls.

Connect with a study center

  • UZ Leuven

    Leuven, 3000
    Belgium

    Site Not Available

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