Curcumin to Prevent Complications After Elective Abdominal Aortic Aneurysm (AAA) Repair

Inclusion Criteria:

• Elective repair of an AAA (excludes thoracic or thoracoabdominal aneurysms)

• 18 years of age or older

• Able to provide informed consent

• Has one or more of the following criteria at time of preoperative assessment:

• x Open repair OR

• x Endovascular repair with ≥ 1 of the following criteria:

• o diabetes mellitus treated with insulin or oral hypoglycemic agents

• o age > 70 years

• o pre-existing renal impairment (baseline serum creatinine level >177 μmol/L for menor >146 μmol/L for women)

• If diabetic, is able and willing to collect and record glucose levels at home

Exclusion Criteria:

• emergent or urgent repair (repair < 3 days from pre-admission visit; ruptured AAA)

• prior renal transplantation

• pregnant or breastfeeding

• active gastrointestinal reflux disease, gastrointestinal ulcers or hepatobiliarydisease (including gallstones)

• has active liver disease

• evidence of AKI (> 50% increase in serum creatinine) in the 30 days prior to repair

• enrolled in another randomized controlled trial

• receipt of ≥ 1 dialysis treatment in the past week

• previous participation in this trial

• repair is scheduled > 90 days from date of informed consent

• unable to provide written consent

• allergy(ies) to any member of the Zingiberaceae family: turmeric, ginger, curry,cumin, cardamom)

• allergy(ies) to ingredients of the study product or placebo: yellow or red foodcoloring, gelatin or cellulose

• have a history of major bleeding event in the previous 6 months

• bleeding disorders: a diagnosis of hemophilia, von Willebrand disease, platelets lessthan 70 for any reason

• history of hypoglycemia in the past 6 months: blood sugar less than or equal to 3.5mmol/L