Effect of Probiotics in the Atopic Dermatitis

Last updated: October 18, 2010
Sponsor: Yuzuncu Yıl University
Overall Status: Completed

Phase

3

Condition

Atopic Dermatitis

Allergy

Dermatitis, Atopic

Treatment

N/A

Clinical Study ID

NCT01224132
JID-2010-0484
  • Ages 8-8
  • All Genders
  • Accepts Healthy Volunteers

Study Summary

This study was designed to evaluate the efficacy of probiotics in the treatment of atopic dermatitis. Probiotics in AD patients were effective in reducing SCORAD index levels, but not effective in skin prick test positivity, serum IL-2-4-5-6-10, TNF-α, IFN-γ, ECP, and serum total and specific IgE levels.

Eligibility Criteria

Inclusion

Inclusion Criteria:SCORAD (SCORing Atopic Dermatitis) index is based on medium-heavy (Carr 2006). Age range is 1-13 with no patient showing evidence of any other disease except theexistent disease -

Exclusion

Exclusion Criteria:No drug was used for 14 (fourteen) days prior to study, includingantihistamines and steroids. Also, no occurrence of malabsorption, such as gastrointestinaldisease, was detected.

Study Design

Total Participants: 40
Study Start date:
October 01, 2007
Estimated Completion Date:
April 30, 2008

Study Description

Frequently encountered in clinical practice, in the last 30 years, the prevalence of AD has rapidly increased as a result of industrialization. Thus, a new wave of quests for the treatment and prevention of AD has pushed forward. For the randomized, double-blinded, and placebo-controlled study this study was designed to evaluate the efficacy of probiotics in the treatment of AD. SCORAD positivity index of decline rates decline rates of the probiotic group of patients after treatment and skin prick tests were higher than that of the control group. While serum levels of IL-2-4-5-6-10, TNF-α, IFN-γ, ECP decreased in the probiotic group, only levels of IL-2-4-5, TNF-α decreased in the control group. The IgE decrease rate, the skin prick test, the serum total and specific of the probiotic group showed no difference from those of the control group. Probiotics in AD patients were effective in reducing SCORAD index levels, but not effective in skin prick test positivity, serum IL-2-4-5-6-10, TNF-α, IFN-γ, ECP, and serum total and specific IgE levels.