Carpentier-Edwards PERIMOUNT Magna Ease Pericardial Bioprosthesis, Model 3300TFX

Inclusion Criteria:

1. The patient requires, as indicated in the preoperative evaluation, a replacementaortic valve.

2. The patient is an average or better operative risk.

3. The patient is geographically stable and agrees to attend follow-up assessments at thehospital of surgical services for at least 8 years.

4. The patient is 18 years or older.

5. The patient has signed and dated the subject informed consent form prior to surgery.

Exclusion Criteria:

1. The patient has any known non-cardiac life-threatening disease, which will limit thepatient's life expectancy below 1 year.

2. The patient presents with active endocarditis within the last 3 months.

3. The patient has an abnormal calcium metabolism (e.g., chronic renal failure,hyperparathyroidism).

4. The patient has an aneurismal aortic degenerative condition (e.g., cystic medialnecrosis, Marfan's syndrome).

5. The patient is pregnant or lactating.

6. The patient is an intravenous drug abuser.

7. The patient is currently a prison inmate.

8. The patient is currently participating in a study of an investigational drug ordevice.

9. The patient requires replacement of a native or prosthetic mitral, tricuspid orpulmonic valve.

10. The patient requires a repair of the mitral or tricuspid valve with the use of anannuloplasty device.

11. The patient was previously enrolled in the study.

12. The patient had a prior mitral, tricuspid or pulmonic valve surgery, which includedimplantation of a bioprosthetic valve, mechanical valve, or annuloplasty ring thatwill remain in situ.