Characterization of Patients With Uncommon Presentations and/or Uncommon Diseases Associated With the Cardiovascular System

Phase

N/A

Condition

Atherosclerosis

Dyskinesias

Inflammation

Treatment

NSR IDE-MRI: Research pulse sequences

11C-Acetate

13N-Amonia

Clinical Study ID

NCT01143454

100126

10-H-0126

Ages 1-100
All Genders
Accepts Healthy Volunteers

Study Summary

Background:

Researchers are interested in studying individuals who have known or suspected metabolic, inflammatory or genetic diseases that may put them at a high risk for heart diseases or diseases of their blood vessels. Depending on the condition being studied, both affected and nonaffected individuals may be asked to provide blood and other samples and may undergo tests to evaluate the heart, blood vessels and lung function. The testing is tailored to the individual and/or condition being studied. Nonaffected individuals may include relatives of affected individuals and healthy nonrelated volunteers.

Objectives:

To study individuals who have or are at risk for cardiovascular diseases, and in some cases their unaffected relatives and healthy volunteers.

Eligibility:

Individuals between 1 and 100 years of age. Participants may be healthy volunteers, individuals with cardiovascular diseases, or unaffected relatives of individuals with cardiovascular diseases.

Design:

Participants will have some or all of the following tests, as directed by the study researchers:
Photography of the face and full body
Body measurements
Radiography, including chest or limb x-rays
Metabolic stress testing to study heart and muscle function
Echocardiography to study heart function
Magnetic resonance imaging (MRI) studies, including cardiovascular MRI, angiography, and contrast MRI, to study heart function and performance
Computed tomography (CT) angiogram to obtain images of the heart and lungs
Positron emission tomography (PET) imaging to study possible fat infiltration of the heart
Six-minute walk test to study heart, lung, and muscle function and performance
Vascular ultrasound to study blood vessel walls
Blood, tissue, and other specimens will be collected for research and testing, and will be taken either as part of the clinical study or during surgical procedures.
Follow-up studies may be performed under separate research protocols.

Eligibility Criteria

Inclusion

INCLUSION CRITERIA:

Eligible subjects may include anyone over 1 year of age who is affected with diseases/disorders (index cases), or who is a relative of a person who is affected with diseases/disorders. Relatives may include genetic carriers and non-carriers.

Healthy adult volunteers must be 18 years of age or older, and must agree to haveblood or tissue samples studied, and potentially stored for future research.
Index cases enrolled in this protocol will have been referred with a known orsuspected pathology that may be associated with cardiovascular dysfunction or riskwith a suspected atypical presentation, heritable disorder, or geneticpredisposition. The investigator with expertise in the presentation of the subject,along with consulting specialists, will review the medical history and may reviewany medical records that are available of prospective subjects and offer admissionbased upon the potential to help the individual, to learn from the subject, or toinitiate clinical or basic research suggested by the subject s workup.

Exclusion

EXCLUSION CRITERIA:

Persons of less than 1 year of age or greater than 100 years of age
Healthy volunteers unable to give informed consent or who decline to have bloodand/or tissue studies, or who do not consent to have samples stored for futureresearch may be excluded from this study.
Pregnant women
Persons who are not fluent in the English language will be excluded from PatientReported Outcome Questionnaires. Such persons would be unable to properly completequestionnaires that are only valid in the English language.

Study Design

NSR IDE-MRI: Research pulse sequences

July 21, 2010

Study Description

We propose to characterize the etiology and natural history of rare and uncommon diseases, both known and unknown that present with symptoms and signs associated with the risk of overt or potential cardiovascular dysfunction. We will also study rare genetic modifiers and identify novel disease mechanisms contributing to common cardiovascular diseases. In so doing, we will expand our knowledge about these disorders and provide access to subjects of interest for research, teaching, and clinical experience. Individual subjects seen under this protocol may initiate the establishment of specific disease-related protocols involving intensive natural history studies, disease discovery and potential innovative therapeutic studies. In addition to its role in investigating individuals who are of interest to the Cardiovascular Branch (CB) of the NHLBI, this protocol can provide a possible avenue for admitting subjects from other NIH programs such as the NIH Undiagnosed Diseases Program, the Center for Human Immunology Trans-institute program or other NIH protocols where subjects exhibit cardiovascular features.

Connect with a study center

Hope Center
Washington D.C., District of Columbia 20006
United States
Active - Recruiting
National Institutes of Health Clinical Center
Bethesda, Maryland 20892
United States
Active - Recruiting
Suburban Hospital
Bethesda, Maryland 20814
United States
Completed
National Institutes of Health Clinical Center
Bethesda 4348599, Maryland 4361885 20892
United States
Active - Recruiting
Suburban Hospital
Bethesda 4348599, Maryland 4361885 20814
United States
Site Not Available

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