The Purpose of This Study is to Demonstrate the Safety and Effectiveness of Calcipotriene Foam in Subjects With Scalp and Body Psoriasis

Inclusion Criteria:

• Capable of understanding and willing to provide signed and dated written voluntaryinformed consent (and any local or national authorization requirements) before anyprotocol-specific procedures are performed.

• Male or female subjects at least 12 years old and in good general health.

• Able to complete the study and to comply with study instructions.

• Moderate plaque-type psoriasis on the body (excluding the scalp and face) defined as:

• Plaque-type psoriasis involving 3% to 10% of total body surface area (BSA).

• An Investigator's Static Global Assessment (ISGA) score of 3 at Baseline.

• Identification of a target lesion (>2 cm²) on the trunk or extremities with ascore of 2 or 3 (0-5 scale) for erythema, scaling and plaque thickness. Lesionson the palms/soles, knees, elbow, and intertriginous areas should not be used asthe target lesion site.

• Involvement of at least 10% of the total scalp surface area with clinical signs (erythema, thickness, and scaliness) rated as moderate (3) based on the ISGA.

• Negative urine pregnancy test for females of childbearing potential. • Sexually activefemales of childbearing potential participating in the study must agree to use amedically acceptable method of contraception while receiving protocol-assignedproduct. A woman of childbearing potential is defined as one who is biologicallycapable of becoming pregnant; including perimenopausal women who are fewer than 2years from their last menses.

Exclusion Criteria:

• Any subject who has participated in any previous calcipotriene foam clinical.

• Female who is pregnant, trying to become pregnant, or breastfeeding.

• Known allergy or other adverse reaction to calcipotriene or other vitamin D analogs;or to any component of the investigational formulations.

• History of hypercalcemia or of vitamin D toxicity.

• Other serious skin disorder or any chronic medical condition that is notwell-controlled.

• Use of nonbiologic systemic anti-psoriatic therapy (eg, corticosteroids, psoralencombined with exposure to ultraviolet light A [PUVA], ultraviolet light B [UVB],retinoids, methotrexate, cyclosporine, other immunosuppressive agents) within 4 weeksprior to enrollment.

• Systemic treatment with biological therapies (marketed or not marketed) with apossible effect on psoriasis within 4 weeks (etanercept), 2 months (adalimumab,alefacept, infliximab), 4 months (ustekinumab) or 4 weeks/5 half-lives (whichever islonger) for experimental products prior to randomization.

• Use of topical therapies that have a known beneficial effect on psoriasis, includingbut not limited to corticosteroids, retinoids, Vitamin D derivatives, coal tar, oranthralin, within 2 weeks prior to enrollment.

• Systemic medications for other medical conditions that are known to affect psoriasis (eg, lithium, beta adrenergic blockers) within 4 weeks prior to enrollment.

• Use of any investigational product within 4 weeks prior to enrollment, currentlyparticipating in another clinical trial, or plans to receive an investigationalproduct during the study.

• Current drug or alcohol abuse (drug screening not required).

• Has a history of any immuno-compromizing disease.

• Any other condition that, in the judgment of the investigator, would put the subjectat unacceptable risk for participation in the study.

• Employees of the investigator; study center; or Stiefel, a GSK company involved in thestudy; or an immediate family member (eg, partner, offspring, parents, siblings orsibling's offspring) of an employee involved in the study.