Study of Vitamin C, Vitamin E and Their Combination to Treat Restless Legs Syndrome in Hemodialysis Patients

Last updated: June 16, 2011
Sponsor: Shiraz University of Medical Sciences
Overall Status: Completed

Phase

2/3

Condition

Nephropathy

Kidney Failure (Pediatric)

Kidney Failure

Treatment

N/A

Clinical Study ID

NCT01125033
86-3893
  • Ages 18-75
  • All Genders

Study Summary

The purpose of this study is to determine whether vitamin C, vitamin E and their combination are effective in the treatment of RLS in hemodialysis patients.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Patients who fulfill Restless leg syndrome international criteria(IRLSSG)

  • Patients who are stable on HD without any internment illness or admission

Exclusion

Exclusion Criteria:

  • Patients who have renal stone

  • Patients who receive medications with RLS aggravating or alleviating properties

Study Design

Total Participants: 60
Study Start date:
March 01, 2008
Estimated Completion Date:
February 28, 2009

Study Description

RLS is a common problem in hemodialysis patients; 20 to 40% of hemodialysis patients suffer from RLS. Hemodialysis patients have a high oxidative stress status. Oxidative stress has been proposed to play an important role in the pathogenesis of RLS. Vitamin C and vitamin E are potent antioxidant agents that have already been shown to be effective in the treatment of periodic limb movement disorder (PLMD) in hemodialysis patients. PLMD is closely associated with RLS in hemodialysis patients. The aim of this study was to evaluate the efficacy of vitamin C, vitamin E and their combination in the treatment of RLS in hemodialysis patients.

Connect with a study center

  • Shiraz University of Medical Sciences

    Shiraz, Fars
    Iran, Islamic Republic of

    Site Not Available

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