Childhood Cancer Survivor Study

Inclusion Criteria:

Initial Cohort:

• Five-year survival following diagnosis of leukemia, lymphoma, CNS tumor, bone tumor,Wilms tumor, neuroblastoma, or soft tissue sarcoma before age 21 years betweenJanuary 1, 1970 and December 31, 1986 at one of participating centers.

Expanded cohort:

• Five-year survival following diagnosis of leukemia, lymphoma, CNS tumor, bone tumor,kidney tumor, neuroblastoma, or rhabdomyosarcoma before age 21 years between January 1, 1987 and December 31, 1999 at one of participating centers.

• English- or Spanish-speaking and living in the U.S. or Canada at the time ofdiagnosis.

Exclusion Criteria:

• Diagnosis of non-malignant tumors (i.e., Langerhans cell histiocytosis, meningioma,craniopharyngioma, etc.) treated with radiation and/or chemotherapy.

• Non-English speaking or residence outside the US or Canada.

Sibling Controls:

• For comparison purposes, a group of sibling controls will be identified to representa stratified random sample based on the distribution of survivors with regard tocancer diagnosis, age, sex, race, and geographic location.