Effect of Nortriptyline in Cortical Representation of Heartburn in Nonerosive Reflux Disease (NERD) Patients

Last updated: July 14, 2012
Sponsor: Universidade de Passo Fundo
Overall Status: Completed

Phase

3

Condition

Heartburn

Gastroesophageal Reflux Disease (Gerd)

Heartburn (Pediatric)

Treatment

N/A

Clinical Study ID

NCT01065649
0102.0.398.000-09
  • Ages > 18
  • All Genders

Study Summary

Patients with nonerosive reflux disease (NERD) are less responsive to standard treatment with proton pump inhibitors. The hypothesis of this study was that nortriptyline in analgesic doses may decrease heartburn perception and its corresponding cortical activity measured by magnetic resonance image. Therefore, the aim of this study was to assess the cortical representation of heartburn in patients with NERD under treatment with nortriptyline and placebo.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • more than 17 years old, heartburn at least twice a week, naive to antirefluxmedications and antidepressive agents

Exclusion

Exclusion Criteria:

  • active esophagitis at endoscopy, contraindications to nortriptyline use

Study Design

Total Participants: 20
Study Start date:
January 01, 2010
Estimated Completion Date:
June 30, 2010

Connect with a study center

  • Kozma

    Passo Fundo, RS 990010-080
    Brazil

    Site Not Available

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