Proton Beam Radiotherapy for Medulloblastoma and Pineoblastoma

Last updated: August 11, 2025
Sponsor: Massachusetts General Hospital
Overall Status: Completed

Phase

N/A

Condition

Brain Cancer

Astrocytoma

Memory Loss

Treatment

proton beam radiation

Clinical Study ID

NCT01063114
09-361
P01CA021239
  • Ages 3-25
  • All Genders

Study Summary

There are two types of external radiation treatments (proton beam and photon beam). As part of the participant's treatment, they will receive radiation to the entire central nervous system (CNS); this is known as craniospinal irradiation (CSI). In the past, photon radiation therapy has been used for CSI. In this study we will be examining the effects of proton beam radiation therapy. Studies have suggested that this kind of radiation can cause less damage to normal tissue than photon radiation therapy. The physical characteristics of proton beam radiation let the doctor safely deliver the amount of radiation delivered to the tumor that is normally delivered through standard therapy but spare more normal tissue in the process.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Participants must have undergone biopsy or attempted surgical resection and musthave histologically confirmed medulloblastoma or pineoblastoma.

  • Participants may have had a gross total resection, sub-total resection or biopsyonly.

  • For patients with no prior chemotherapy, treatment must start within 35 days ofdefinitive surgery or as indicated if enrolled on therapeutic study

  • Age range between 3 and 25 at the time of enrollment

  • Life expectancy of greater than 3 months

  • Blood laboratory values as outlined in the protocol

  • Women of child-bearing potential and men must agree to use adequate contraceptionprior to study entry and for the duration of study participation

Exclusion

Exclusion Criteria:

  • Patients with more than one previous chemotherapy regimen

  • Patients with recurrent or progressive disease after one or more regimens ofpre-radiation chemotherapy

  • Patients with prior radiation therapy

  • Any major uncontrolled or poorly controlled intercurrent illness that would limitcompliance with study requirements

  • Pregnant women

Study Design

Total Participants: 90
Treatment Group(s): 1
Primary Treatment: proton beam radiation
Phase:
Study Start date:
April 08, 2010
Estimated Completion Date:
November 30, 2021

Study Description

  • Before beginning radiation therapy, participants will have scans done in order to prepare for the radiation treatment. Doctors will use information gathered from these scans to plan the best way to deliver radiation to the tumor.

  • The following procedures will be performed either before or during the radiotherapy: Hearing exam; neurocognitive exam; blood tests and cerebral spinal fluid test.

  • Not everyone who participates in this study will receive the same amount of proton radiation therapy. The length of time and amount of radiation received will depend upon the condition of the participant's disease. Radiation treatment will be given once a day, 5 days a week (Monday-Friday). The overall treatment course will be approximately 6 weeks.

Connect with a study center

  • Massachusetts General Hospital

    Boston, Massachusetts 02115
    United States

    Site Not Available

  • MD Anderson Cancer Center

    Houston, Texas 77030
    United States

    Site Not Available

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