Role of Skeletal Muscle Nitric Oxide Production in Age-related Fatigue and Fatigability

Last updated: February 6, 2019
Sponsor: The University of Texas Medical Branch, Galveston
Overall Status: Completed

Phase

N/A

Condition

Pain (Pediatric)

Aging

Treatment

N/A

Clinical Study ID

NCT01059994
09-213
  • Ages 20-80
  • Male
  • Accepts Healthy Volunteers

Study Summary

This is a pilot study funded by the National Institutes of Health. In this project, we will investigate the potential effect of skeletal muscle nitric oxide (NO) production on muscle strength and physical function in older individuals. We propose to test a new method that may enable simultaneous determination of both vascular and skeletal muscle NO production for the first time in humans. Further, we will determine whether augmentation of NO-mediated responses, by administration of sildenafil citrate (Viagra), reduces fatigue and fatigability in older individuals.

Eligibility Criteria

Inclusion

Inclusion Criteria:

    1. Age 20-35 yrs, and 60-80 yrs.
    1. Ability to sign consent form (score >23 on the 30-item Mini Mental StateExamination, MMSE)
    1. Stable body weight for at least 3 months

Exclusion

Exclusion Criteria:

    1. Physical dependence or frailty (impairment in any of the Activities of Daily Living (ADL), history of falls (>2/year) or significant weight loss in the past year)
    1. Exercise training (>2 weekly sessions of moderate to high intensity aerobic orresistance exercise)
    1. Pregnancy
    1. Significant heart, liver, kidney, blood or respiratory disease
    1. Peripheral vascular disease
    1. Diabetes mellitus or other untreated endocrine disease
    1. Active cancer
    1. Use of nitrates
    1. Recent (within 6 months) treatment with anabolic steroids, or corticosteroids.
    1. Alcohol or drug abuse
    1. Severe depression (>5 on the 15-item Geriatric Depression Scale, GDS)
    1. Cardiac abnormalities such as a cardiac shunt or previously diagnosed pulmonaryhypertension.
    1. Systolic blood pressure <100 or >150, diastolic blood pressure <60 or >90.

Study Design

Total Participants: 12
Study Start date:
January 01, 2010
Estimated Completion Date:
July 31, 2013

Connect with a study center

  • University of Texas Medical Branch

    Galveston, Texas 77555
    United States

    Site Not Available

Map preview placeholder

Not the study for you?

Let us help you find the best match. Sign up as a volunteer and receive email notifications when clinical trials are posted in the medical category of interest to you.