Development of Knee Osteoarthritis After Arthroscopic Partial Resection of Degenerative Meniscus Tear

Last updated: January 20, 2015
Sponsor: Tampere University
Overall Status: Active - Enrolling

Phase

4

Condition

Osteoarthritis

Orthopedics

Treatment

N/A

Clinical Study ID

NCT01052233
9037/403/2006
  • Ages 35-65
  • All Genders

Study Summary

It has been previously demonstrated that the risk for the development of knee osteoarthritis is increased after both meniscus tear and meniscectomy. However, it is still unclear whether this is due to the meniscus tear per se, the surgery, or whether the development of knee osteoarthritis is completely independent of the two. Accordingly, the aim of the study is to investigate the effect of arthroscopic partial meniscectomy on the development of knee osteoarthritis 2 to 10 years after the procedure.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  1. Age: 35 to 65 years of age.

  2. A pain located on the medial joint line of the knee that has persistent at least for 3months.

  3. Pain that can be provoked by palpation or compression of the joint line or a positiveMcMurray sign.

  4. Tear of the medial meniscus on MRI.

  5. Degenerative rupture of the medial meniscus confirmed at arthroscopy.

Exclusion

Exclusion Criteria:

  1. Acute, trauma-induced onset of symptoms.

  2. Locking or painful snapping of the knee joint.

  3. A surgical operation performed on the affected knee.

  4. Osteoarthritis of the medial compartment of the knee (determined by clinical criteriaof the ACR).

  5. Osteoarthritis on knee radiographs (Kellgren-Lawrence > 1).

  6. Acute (within the previous year) fractures of the knee.

  7. Decreased range of motion of the knee.

  8. Instability of the knee.

  9. MRI assessment showing a tumor or any other complaint requiring surgical or othermeans of treatment.

  10. Arthroscopic assessment showing anything other than a degenerative tear of the medialmeniscus requiring surgical intervention.

Study Design

Total Participants: 160
Study Start date:
January 01, 2010
Estimated Completion Date:
January 31, 2024

Study Description

It has been previously demonstrated that the risk for the development/progression of knee osteoarthritis is increased after both meniscus tear and meniscectomy. However, it is still unclear whether this is due to the meniscus tear per se (i.e., adverse mechanical effect on knee cartilage), the surgery (resection of the meniscus, and subsequent loss of cushion within the knee), or whether the development of knee osteoarthritis is completely independent of the two.

Accordingly, the aim of the study is to investigate the effect of Arthroscopic partial meniscectomy on the development of knee osteoarthritis 2 to 10 years after the procedure.

Patients included in the study will be randomized into one of two groups: arthroscopic partial meniscectomy and diagnostic arthroscopy (sham-surgery). The presence of knee osteoarthritis will be assessed preoperatively and 2, 5, and 10 years after the operation.

Connect with a study center

  • Helsinki Central Hospital

    Helsinki,
    Finland

    Site Not Available

  • Central Finland Hospital District

    Jyväskylä,
    Finland

    Site Not Available

  • Central Finland Hospital District

    Jyväskylä,
    Finland

    Site Not Available

  • Kuopio University Hospital

    Kuopio,
    Finland

    Site Not Available

  • Tampere City Hospital

    Tampere, 33101
    Finland

    Site Not Available

  • Turku University Hospital

    Turku,
    Finland

    Site Not Available

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