AZD7268 Safety and Tolerability Study

Inclusion Criteria:

• Provision of signed, written, and dated Informed Consent prior to any study specificprocedures

• Documented primary clinical diagnosis meeting criteria from the DSM-IV, Text Revision (APA 2000) for any of the following:

• 296.2x Major Depressive Disorder, Single Episode, or

• 296.3x Major Depressive Disorder, Recurrent

Exclusion Criteria:

• Patients with a secondary DSM-IV Axis I disorder other than GAD or social anxietydisorder (as assessed by MINI), provided the primary diagnosis is MDD. This diagnosisshould have been made at least 6 months before enrollment

• Patients with a diagnosis of DSM-IV Axis II disorder which has a major impact on thepatient's current psychiatric status

• Patients whose current episode of depression started less than 4 weeks beforeenrollment