Efficacy and Safety of Specific Immunotherapy With CLUSTOID Grass Pollen

Inclusion Criteria:

• Positive history of allergic rhinitis/rhinoconjunctivitis due to grass and/or ryepollen

• Positive screening skin prick test (wheal diameter > 3 mm)

• Compliance and ability of the patient to complete a Diary Card for self-evaluating ofthe symptoms and antisymptomatic medication

• Signed and dated patient´s Informed Consent,

Exclusion Criteria:

• Previous immunotherapy with grass and/or rye pollen extracts within the last 3 years,

• Simultaneous participation in other clinical trials,

• Other reasons contra-indicating an inclusion into the trial according to theinvestigator´s estimation (e.g. poor compliance),

• Auto-immune disorders,

• Severe chronic inflammatory diseases,

• Malignancy,

• Alcohol abuse,

• Existing or intended pregnancy, lactation and/or lack of adequate contraceptiveprotection,

• Patients being in any relationship or dependency with the sponsor and/or investigator,

• Treatment with beta-blockers (incl. local application) and/or other contra-indicateddrugs.