Gemcitabine Hydrochloride and Docetaxel With or Without Bevacizumab in Treating Patients With Advanced or Recurrent Uterine Leiomyosarcoma

Last updated: August 20, 2020
Sponsor: National Cancer Institute (NCI)
Overall Status: Terminated

Phase

3

Condition

Infantile Fibrosarcoma

Sarcoma

Sarcoma (Pediatric)

Treatment

Docetaxel

Gemcitabine Hydrochloride

Placebo

Clinical Study ID

NCT01012297
NCI-2010-01738
NCI-2010-01738
GOG-0250
U10CA027469
CDR0000659024
  • Ages > 18
  • Female

Study Summary

This randomized phase III trial is studying gemcitabine hydrochloride, docetaxel, and bevacizumab to see how well they work compared with gemcitabine hydrochloride, docetaxel, and a placebo in treating patients with advanced or recurrent uterine leiomyosarcoma. Drugs used in chemotherapy, such as gemcitabine hydrochloride and docetaxel, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Monoclonal antibodies, such as bevacizumab, can block tumor growth in different ways. Some block the ability of tumor cells to grow and spread. Others find tumor cells and help kill them or carry tumor-killing substances to them. Bevacizumab may also stop the growth of tumor cells by blocking blood flow to the tumor. It is not yet known whether gemcitabine hydrochloride and docetaxel are more effective when given with or without bevacizumab in treating uterine leiomyosarcoma.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Patients must have advanced or recurrent uterine leiomyosarcoma with documenteddisease progression; histologic confirmation of the original primary tumor is required

  • All patients must have measurable disease as defined by RECIST 1.1; measurable diseaseis defined as at least one lesion that can be accurately measured in at least onedimension (longest diameter to be recorded); each lesion must be >= 10 mm whenmeasured by CT, MRI or caliper measurement by clinical exam; or >= 20 mm when measuredby chest x-ray; lymph nodes must be >= 15 mm in short axis when measured by CT or MRI

  • Patient must have at least one "target lesion" to be used to assess response on thisprotocol as defined by RECIST 1.1; tumors within a previously irradiated field will bedesignated as "non-target" lesions unless progression is documented or a biopsy isobtained to confirm persistence at least 90 days following completion of radiationtherapy

  • Patients must have a GOG Performance Status of 0, 1, or 2

  • Patients must have recovered from effects of recent surgery, radiotherapy or othertherapy

  • Patients should be free of active infection requiring antibiotics (with the exceptionof an uncomplicated UTI)

  • Any hormonal therapy directed at the malignant tumor must be discontinued at least oneweek prior to first day of study treatment; continuation of hormone replacementtherapy is permitted

  • Platelet count greater than or equal to 100,000/mm^3

  • ANC count greater than or equal to 1,500/mm^3

  • Creatinine less than or equal to 1.5 x institutional upper limit normal (ULN), per NCICTCAE Version 4.0 Grade 1

  • Bilirubin within normal range (CTCAE Version 4 Grade 0)

  • SGOT and alkaline phosphatase less than or equal to 2.5 x ULN, per the CTCAE Version 4.0 Grade 1)

  • SGOT less than or equal to 2.5 x ULN, per the CTCAE Version 4.0 Grade 1

  • Alkaline phosphatase less than or equal to 2.5 x ULN, per the CTCAE Version 4.0 Grade 1

  • Neuropathy (sensory and motor) less than or equal to Grade 1 per the CTCAE Version 4.0.

  • No history of transient ischemic attack (TIA) or stroke or CNS hemorrhage within thepast 6 months

  • Urine protein creatinine (UPC) ratio must be < 1.0 gm; if UPC ratio >= 1, collectionof 24-hour urine measurement of urine protein is recommended

  • PT such that international normalized ratio (INR) is =< 1.5 and a PTT =< 1.5 times theinstitutional upper limit of normal (or an in-therapeutic-range INR, usually between 2and 3, if a patient is on a stable dose of therapeutic warfarin)

  • Patients must have signed an approved informed consent and authorization permittingrelease of personal health information

  • Patients must meet pre-entry requirements

  • Patients of childbearing potential must have a negative serum pregnancy test prior tothe study entry and be practicing an effective form of contraception

Exclusion

Exclusion Criteria:

  • Patients who have received prior cytotoxic chemotherapy for management of uterinesarcoma; patients who have received prior VEGF-pathway targeted agent such asbevacizumab, PTK787, VEGF-trap, or who have received prior treatment with amulti-kinase inhibitor such as sorafenib or sunitinib are not eligible

  • Patients who have had prior therapy with docetaxel or gemcitabine or bevacizumab

  • Patients with a history of other invasive malignancies, with the exceptions ofnon-melanoma skin cancer, carcinoma in situ of the cervix, and ductal carcinoma insitu of the breast, are excluded if there is any evidence of other malignancy beingpresent within the last five years; patients are also excluded if their previouscancer treatment contraindicates this protocol therapy

  • Patients with active bleeding or pathologic conditions that carry high risk ofbleeding, such as known bleeding disorder, coagulopathy, or tumor involving majorvessels; (necessary use of warfarin or low molecular weight heparin is permitted,provided the INR is maintained in the therapeutic range of approximately 2-3)

  • Patients with major surgery or significant traumatic injury within 28 days prior tostudy entry

  • Patients with a history of abdominal fistula or perforation within the past 12 months

  • Patients with a current, serious, non-healing wound, ulcer, or bone fracture

  • Patients with history or evidence upon physical examination of CNS disease, includinghistory of primary brain tumor, or any history of brain metastases, or seizures notcontrolled with standard medical therapy

  • Patients with known hypersensitivity to Chinese hamster ovary cell products or otherrecombinant human or humanized antibodies

  • Cardiovascular function; specifically, patient may not have:

  • Uncontrolled hypertension, defined as systolic > 150 mm Hg or diastolic > 100 mmHg in a patient with no history of hypertension; patients with a history ofhypertension before enrollment on study are permitted, but such patients musthave BP less than or equal to 140/90 mmHg; use of blood pressure medications toachieve and maintain blood pressure control is permitted

  • Myocardial infarction or unstable angina within 6 months of the first date ofbevacizumab/placebo therapy

  • New York Heart Association (NYHA) Grade II or greater congestive heart failure orserious cardiac arrhythmia requiring medication; women who have received priortreatment with an anthracycline (including doxorubicin and/or liposomaldoxorubicin) and have an ejection fraction < 50% will be excluded from the study

  • Grade 1, Category 2 or greater, peripheral vascular disease; patient cannot haveanything worse than mild, symptomatic claudication with exercise

  • History of cerebrovascular accident (CVA, stroke), transient ischemic attack (TIA) or subarachnoid hemorrhage within six months of the first date ofbevacizumab/placebo therapy

  • History of pulmonary embolism or deep vein thrombosis in the past 6 months

  • Patients with, or with anticipation of, invasive procedures as defined below:

  • Major surgical procedure, open biopsy or significant traumatic injury within 28days prior to the first date of bevacizumab/placebo therapy

  • Major surgical procedure anticipated during the course of the study.

  • Minor surgical procedures (i.e., mediport insertion), fine needle aspirates, orcore biopsies within 7 days prior to the first date of bevacizumab/placebotherapy

  • Patients who are pregnant or nursing

Study Design

Total Participants: 107
Treatment Group(s): 6
Primary Treatment: Docetaxel
Phase: 3
Study Start date:
November 01, 2009
Estimated Completion Date:
September 30, 2015

Study Description

PRIMARY OBJECTIVES:

I. To determine whether the addition of bevacizumab to fixed-dose rate gemcitabine-docetaxel reduces the progression-free survival (PFS) event rate when compared to gemcitabine-docetaxel plus placebo in patients with advanced or recurrent uterine leiomyosarcoma (LMS).

SECONDARY OBJECTIVES:

I. To determine the objective response rate, as measured by RECIST, of patients treated with fixed-dose rate gemcitabine-docetaxel with bevacizumab, compared with the objective response rate of patients treated with fixed-dose rate gemcitabine-docetaxel with placebo.

II. To determine if the addition of bevacizumab to the combination of gemcitabine and docetaxel increases overall survival in patients with advanced or recurrent uterine LMS.

III. To determine the toxicity profile of fixed-dose rate gemcitabine-docetaxel with and without bevacizumab in this patient population.

IV. To bank formalin-fixed and paraffin-embedded (FFPE) tumor tissue for research.

OUTLINE: This is a multicenter study. Patients are stratified according to prior whole-pelvic radiotherapy (yes vs no). Patients are randomized to 1 of 2 treatment arms.

ARM I: Patients receive a placebo IV over 30-90 minutes on day 1, gemcitabine hydrochloride IV over 90 minutes on days 1 and 8, and docetaxel IV over 60 minutes on day 8. Patients also receive filgrastim subcutaneously (SC) on days 9-15 or pegfilgrastim SC on day 9 or 10.

ARM II: Patients receive bevacizumab IV over 30-90 minutes on day 1, gemcitabine hydrochloride IV over 90 minutes on days 1 and 8, and docetaxel IV over 60 minutes on day 8. Patients also receive filgrastim SC on days 9-15 or pegfilgrastim SC on day 9 or 10.

In both arms, courses repeat every 21 days in the absence of disease progression or unacceptable toxicity.

After completion of study treatment, patients are followed up every 3 months for 2 years and then every 6 months for 3 years.

Connect with a study center

  • Saint Joseph's Hospital and Medical Center

    Phoenix, Arizona 85013
    United States

    Site Not Available

  • Providence Saint Joseph Medical Center/Disney Family Cancer Center

    Burbank, California 91505
    United States

    Site Not Available

  • John Muir Medical Center-Concord Campus

    Concord, California 94520
    United States

    Site Not Available

  • UC San Diego Moores Cancer Center

    La Jolla, California 92093
    United States

    Site Not Available

  • Kaiser Permanente Los Angeles Medical Center

    Los Angeles, California 90027
    United States

    Site Not Available

  • Los Angeles County-USC Medical Center

    Los Angeles, California 90033
    United States

    Site Not Available

  • UCLA / Jonsson Comprehensive Cancer Center

    Los Angeles, California 90095
    United States

    Site Not Available

  • USC / Norris Comprehensive Cancer Center

    Los Angeles, California 90033
    United States

    Site Not Available

  • Palo Alto Medical Foundation-Gynecologic Oncology

    Mountain View, California 94040
    United States

    Site Not Available

  • UC Irvine Health/Chao Family Comprehensive Cancer Center

    Orange, California 92868
    United States

    Site Not Available

  • University of California San Diego

    San Diego, California 92103
    United States

    Site Not Available

  • UCSF Medical Center-Mount Zion

    San Francisco, California 94115
    United States

    Site Not Available

  • Olive View-University of California Los Angeles Medical Center

    Sylmar, California 91342
    United States

    Site Not Available

  • John Muir Medical Center-Walnut Creek

    Walnut Creek, California 94598
    United States

    Site Not Available

  • The Medical Center of Aurora

    Aurora, Colorado 80012
    United States

    Site Not Available

  • University of Colorado Cancer Center - Anschutz Cancer Pavilion

    Aurora, Colorado 80045
    United States

    Site Not Available

  • Boulder Community Hospital

    Boulder, Colorado 80301
    United States

    Site Not Available

  • Penrose-Saint Francis Healthcare

    Colorado Springs, Colorado 80907
    United States

    Site Not Available

  • Colorado Cancer Research Program CCOP

    Denver, Colorado 80224-2522
    United States

    Site Not Available

  • Exempla Saint Joseph Hospital

    Denver, Colorado 80218
    United States

    Site Not Available

  • Porter Adventist Hospital

    Denver, Colorado 80210
    United States

    Site Not Available

  • Presbyterian - Saint Lukes Medical Center - Health One

    Denver, Colorado 80218
    United States

    Site Not Available

  • Rose Medical Center

    Denver, Colorado 80220
    United States

    Site Not Available

  • Rocky Mountain Gynecologic Oncology PC

    Englewood, Colorado 80110
    United States

    Site Not Available

  • Swedish Medical Center

    Englewood, Colorado 80113
    United States

    Site Not Available

  • Saint Mary's Hospital and Regional Medical Center

    Grand Junction, Colorado 81502
    United States

    Site Not Available

  • North Colorado Medical Center

    Greeley, Colorado 80631
    United States

    Site Not Available

  • Saint Anthony Hospital

    Lakewood, Colorado 80228
    United States

    Site Not Available

  • Littleton Adventist Hospital

    Littleton, Colorado 80122
    United States

    Site Not Available

  • Sky Ridge Medical Center

    Lone Tree, Colorado 80124
    United States

    Site Not Available

  • Longmont United Hospital

    Longmont, Colorado 80501
    United States

    Site Not Available

  • McKee Medical Center

    Loveland, Colorado 80539
    United States

    Site Not Available

  • Parker Adventist Hospital

    Parker, Colorado 80138
    United States

    Site Not Available

  • Saint Mary Corwin Medical Center

    Pueblo, Colorado 81004
    United States

    Site Not Available

  • North Suburban Medical Center

    Thornton, Colorado 80229
    United States

    Site Not Available

  • SCL Health Lutheran Medical Center

    Wheat Ridge, Colorado 80033
    United States

    Site Not Available

  • Hartford Hospital

    Hartford, Connecticut 06102
    United States

    Site Not Available

  • The Hospital of Central Connecticut

    New Britain, Connecticut 06050
    United States

    Site Not Available

  • Beebe Medical Center

    Lewes, Delaware 19958
    United States

    Site Not Available

  • Christiana Care Health System-Christiana Hospital

    Newark, Delaware 19718
    United States

    Site Not Available

  • Washington Hospital Center

    Washington, District of Columbia 20010
    United States

    Site Not Available

  • Washington Hospital Center

    Washington, D.C., District of Columbia 20010
    United States

    Site Not Available

  • Mayo Clinic in Florida

    Jacksonville, Florida 32224-9980
    United States

    Site Not Available

  • Mercy Hospital

    Miami, Florida 33133
    United States

    Site Not Available

  • University of Miami Miller School of Medicine-Sylvester Cancer Center

    Miami, Florida 33136
    United States

    Site Not Available

  • Florida Hospital Orlando

    Orlando, Florida 32803
    United States

    Site Not Available

  • UF Cancer Center at Orlando Health

    Orlando, Florida 32806
    United States

    Site Not Available

  • Georgia Regents University Medical Center

    Augusta, Georgia 30912
    United States

    Site Not Available

  • John B Amos Cancer Center

    Columbus, Georgia 31904
    United States

    Site Not Available

  • Memorial University Medical Center

    Savannah, Georgia 31404
    United States

    Site Not Available

  • Northwestern University

    Chicago, Illinois 60611
    United States

    Site Not Available

  • Rush University Medical Center

    Chicago, Illinois 60612
    United States

    Site Not Available

  • University of Chicago Comprehensive Cancer Center

    Chicago, Illinois 60637
    United States

    Site Not Available

  • Sudarshan K Sharma MD Limted-Gynecologic Oncology

    Hinsdale, Illinois 60521
    United States

    Site Not Available

  • Memorial Medical Center

    Springfield, Illinois 62781
    United States

    Site Not Available

  • Cadence Cancer Center in Warrenville

    Warrenville, Illinois 60555
    United States

    Site Not Available

  • Saint Francis Hospital and Health Centers

    Beech Grove, Indiana 46107
    United States

    Site Not Available

  • Elkhart Clinic

    Elkhart, Indiana 46514-2098
    United States

    Site Not Available

  • Elkhart General Hospital

    Elkhart, Indiana 46515
    United States

    Site Not Available

  • Michiana Hematology Oncology PC-Elkhart

    Elkhart, Indiana 46514
    United States

    Site Not Available

  • Franciscan Saint Francis Health-Indianapolis

    Indianapolis, Indiana 46237
    United States

    Site Not Available

  • Gynecologic Oncology of Indiana

    Indianapolis, Indiana 46237
    United States

    Site Not Available

  • Indiana University/Melvin and Bren Simon Cancer Center

    Indianapolis, Indiana 46202
    United States

    Site Not Available

  • Saint Vincent Oncology Center

    Indianapolis, Indiana 46260
    United States

    Site Not Available

  • Community Howard Regional Health

    Kokomo, Indiana 46904
    United States

    Site Not Available

  • IU Health La Porte Hospital

    La Porte, Indiana 46350
    United States

    Site Not Available

  • Michiana Hematology Oncology PC-Mishawaka

    Mishawaka, Indiana 46545
    United States

    Site Not Available

  • Saint Joseph Regional Medical Center-Mishawaka

    Mishawaka, Indiana 46545
    United States

    Site Not Available

  • Michiana Hematology Oncology PC-Plymouth

    Plymouth, Indiana 46563
    United States

    Site Not Available

  • Memorial Hospital of South Bend

    South Bend, Indiana 46601
    United States

    Site Not Available

  • Michiana Hematology Oncology PC-South Bend

    South Bend, Indiana 46601
    United States

    Site Not Available

  • Northern Indiana Cancer Research Consortium CCOP

    South Bend, Indiana 46628
    United States

    Site Not Available

  • South Bend Clinic

    South Bend, Indiana 46617
    United States

    Site Not Available

  • Michiana Hematology Oncology PC-Westville

    Westville, Indiana 46391
    United States

    Site Not Available

  • Medical Oncology and Hematology Associates-West Des Moines

    Clive, Iowa 50325
    United States

    Site Not Available

  • Mercy Cancer Center-West Lakes

    Clive, Iowa 50325
    United States

    Site Not Available

  • Iowa Lutheran Hospital

    Des Moines, Iowa 50316
    United States

    Site Not Available

  • Iowa Methodist Medical Center

    Des Moines, Iowa 50309
    United States

    Site Not Available

  • Iowa Oncology Research Association CCOP

    Des Moines, Iowa 50309
    United States

    Site Not Available

  • Medical Oncology and Hematology Associates-Des Moines

    Des Moines, Iowa 50309
    United States

    Site Not Available

  • Medical Oncology and Hematology Associates-Laurel

    Des Moines, Iowa 50314
    United States

    Site Not Available

  • Mercy Medical Center - Des Moines

    Des Moines, Iowa 50314
    United States

    Site Not Available

  • University of Iowa/Holden Comprehensive Cancer Center

    Iowa City, Iowa 52242
    United States

    Site Not Available

  • Mercy Medical Center-West Lakes

    West Des Moines, Iowa 50266
    United States

    Site Not Available

  • Methodist West Hospital

    West Des Moines, Iowa 50266-7700
    United States

    Site Not Available

  • University of Kansas Cancer Center

    Kansas City, Kansas 66160
    United States

    Site Not Available

  • Baptist Health Lexington

    Lexington, Kentucky 40503
    United States

    Site Not Available

  • Norton Hospital Pavilion and Medical Campus

    Louisville, Kentucky 40202
    United States

    Site Not Available

  • The James Graham Brown Cancer Center at University of Louisville

    Louisville, Kentucky 40202
    United States

    Site Not Available

  • Greater Baltimore Medical Center

    Baltimore, Maryland 21204
    United States

    Site Not Available

  • Johns Hopkins University/Sidney Kimmel Cancer Center

    Baltimore, Maryland 21287
    United States

    Site Not Available

  • MedStar Franklin Square Medical Center/Weinberg Cancer Institute

    Baltimore, Maryland 21237
    United States

    Site Not Available

  • University of Maryland/Greenebaum Cancer Center

    Baltimore, Maryland 21201
    United States

    Site Not Available

  • Walter Reed National Military Medical Center

    Bethesda, Maryland 20889-5600
    United States

    Site Not Available

  • Union Hospital of Cecil County

    Elkton, Maryland 21921
    United States

    Site Not Available

  • Union Hospital of Cecil County

    Elkton MD, Maryland 21921
    United States

    Site Not Available

  • Lahey Hospital and Medical Center

    Burlington, Massachusetts 01805
    United States

    Site Not Available

  • Bronson Battle Creek

    Battle Creek, Michigan 49017
    United States

    Site Not Available

  • Spectrum Health Big Rapids Hospital

    Big Rapids, Michigan 49307
    United States

    Site Not Available

  • Wayne State University/Karmanos Cancer Institute

    Detroit, Michigan 48201
    United States

    Site Not Available

  • Grand Rapids Clinical Oncology Program

    Grand Rapids, Michigan 49503
    United States

    Site Not Available

  • Mercy Health Saint Mary's

    Grand Rapids, Michigan 49503
    United States

    Site Not Available

  • Spectrum Health at Butterworth Campus

    Grand Rapids, Michigan 49503
    United States

    Site Not Available

  • Borgess Medical Center

    Kalamazoo, Michigan 49001
    United States

    Site Not Available

  • Bronson Methodist Hospital

    Kalamazoo, Michigan 49007
    United States

    Site Not Available

  • West Michigan Cancer Center

    Kalamazoo, Michigan 49007
    United States

    Site Not Available

  • Mercy Health Mercy Campus

    Muskegon, Michigan 49444
    United States

    Site Not Available

  • Michiana Hematology Oncology PC-Niles

    Niles, Michigan 49120
    United States

    Site Not Available

  • Spectrum Health Reed City Hospital

    Reed City, Michigan 49677
    United States

    Site Not Available

  • Lakeland Hospital

    Saint Joseph, Michigan 49085
    United States

    Site Not Available

  • Marie Yeager Cancer Center

    Saint Joseph, Michigan 49085
    United States

    Site Not Available

  • Lakeland Hospital

    St. Joseph, Michigan 49085
    United States

    Site Not Available

  • Munson Medical Center

    Traverse City, Michigan 49684
    United States

    Site Not Available

  • Metro Health Hospital

    Wyoming, Michigan 49519
    United States

    Site Not Available

  • Fairview Ridges Hospital

    Burnsville, Minnesota 55337
    United States

    Site Not Available

  • Mercy Hospital

    Coon Rapids, Minnesota 55433
    United States

    Site Not Available

  • Fairview-Southdale Hospital

    Edina, Minnesota 55435
    United States

    Site Not Available

  • Unity Hospital

    Fridley, Minnesota 55432
    United States

    Site Not Available

  • Hutchinson Area Health Care

    Hutchinson, Minnesota 55350
    United States

    Site Not Available

  • Minnesota Oncology Hematology PA-Maplewood

    Maplewood, Minnesota 55109
    United States

    Site Not Available

  • Saint John's Hospital - Healtheast

    Maplewood, Minnesota 55109
    United States

    Site Not Available

  • Abbott-Northwestern Hospital

    Minneapolis, Minnesota 55407
    United States

    Site Not Available

  • Hennepin County Medical Center

    Minneapolis, Minnesota 55415
    United States

    Site Not Available

  • New Ulm Medical Center

    New Ulm, Minnesota 56073
    United States

    Site Not Available

  • North Memorial Medical Health Center

    Robbinsdale, Minnesota 55422
    United States

    Site Not Available

  • Mayo Clinic

    Rochester, Minnesota 55905
    United States

    Site Not Available

  • Metro-Minnesota NCI Community Oncology Research Program

    Saint Louis Park, Minnesota 55416
    United States

    Site Not Available

  • Park Nicollet Clinic - Saint Louis Park

    Saint Louis Park, Minnesota 55416
    United States

    Site Not Available

  • Regions Hospital

    Saint Paul, Minnesota 55101
    United States

    Site Not Available

  • United Hospital

    Saint Paul, Minnesota 55102
    United States

    Site Not Available

  • Saint Francis Regional Medical Center

    Shakopee, Minnesota 55379
    United States

    Site Not Available

  • Regions Hospital Cancer Care Center

    St. Paul, Minnesota 55101
    United States

    Site Not Available

  • Lakeview Hospital

    Stillwater, Minnesota 55082
    United States

    Site Not Available

  • Ridgeview Medical Center

    Waconia, Minnesota 55387
    United States

    Site Not Available

  • Rice Memorial Hospital

    Willmar, Minnesota 56201
    United States

    Site Not Available

  • Minnesota Oncology and Hematology PA-Woodbury

    Woodbury, Minnesota 55125
    United States

    Site Not Available

  • University of Mississippi Medical Center

    Jackson, Mississippi 39216
    United States

    Site Not Available

  • Washington University School of Medicine

    Saint Louis, Missouri 63110
    United States

    Site Not Available

  • Cancer Research for the Ozarks NCORP

    Springfield, Missouri 65804
    United States

    Site Not Available

  • CoxHealth South Hospital

    Springfield, Missouri 65807
    United States

    Site Not Available

  • Mercy Hospital Springfield

    Springfield, Missouri 65804
    United States

    Site Not Available

  • Nebraska Methodist Hospital

    Omaha, Nebraska 68114
    United States

    Site Not Available

  • Women's Cancer Center of Nevada

    Las Vegas, Nevada 89169
    United States

    Site Not Available

  • Center of Hope at Renown Medical Center

    Reno, Nevada 89502
    United States

    Site Not Available

  • Dartmouth Hitchcock Medical Center

    Lebanon, New Hampshire 03756
    United States

    Site Not Available

  • Cooper Hospital University Medical Center

    Camden, New Jersey 08103
    United States

    Site Not Available

  • Fox Chase Virtua Health Cancer Program at Virtua Memorial Hospital Marlton

    Marlton, New Jersey 08053
    United States

    Site Not Available

  • Morristown Medical Center

    Morristown, New Jersey 07960
    United States

    Site Not Available

  • Virtua Memorial

    Mount Holly, New Jersey 08060
    United States

    Site Not Available

  • Rutgers Cancer Institute of New Jersey

    New Brunswick, New Jersey 08903
    United States

    Site Not Available

  • UMDNJ - Robert Wood Johnson University Hospital

    New Brunswick, New Jersey 08903
    United States

    Site Not Available

  • Overlook Hospital

    Summit, New Jersey 07902
    United States

    Site Not Available

  • Virtua West Jersey Hospital Voorhees

    Voorhees, New Jersey 08043
    United States

    Site Not Available

  • Southwest Gynecologic Oncology Associates Inc

    Albuquerque, New Mexico 87106
    United States

    Site Not Available

  • University of New Mexico

    Albuquerque, New Mexico 87102
    United States

    Site Not Available

  • University of New Mexico Cancer Center

    Albuquerque, New Mexico 87106
    United States

    Site Not Available

  • Memorial Medical Center - Las Cruces

    Las Cruces, New Mexico 88011
    United States

    Site Not Available

  • Women's Cancer Care Associates LLC

    Albany, New York 12208
    United States

    Site Not Available

  • State University of New York Downstate Medical Center

    Brooklyn, New York 11203
    United States

    Site Not Available

  • Memorial Sloan-Kettering Cancer Center

    New York, New York 10065
    United States

    Site Not Available

  • Mount Sinai Medical Center

    New York, New York 10029
    United States

    Site Not Available

  • Stony Brook University Medical Center

    Stony Brook, New York 11794
    United States

    Site Not Available

  • Carolinas Medical Center/Levine Cancer Institute

    Charlotte, North Carolina 28203
    United States

    Site Not Available

  • Novant Health Presbyterian Medical Center

    Charlotte, North Carolina 28204
    United States

    Site Not Available

  • Carolinas HealthCare System NorthEast

    Concord, North Carolina 28025
    United States

    Site Not Available

  • Duke University Medical Center

    Durham, North Carolina 27710
    United States

    Site Not Available

  • Wake Forest University Health Sciences

    Winston-Salem, North Carolina 27157
    United States

    Site Not Available

  • Summa Akron City Hospital/Cooper Cancer Center

    Akron, Ohio 44304
    United States

    Site Not Available

  • University of Cincinnati

    Cincinnati, Ohio 45267
    United States

    Site Not Available

  • Case Western Reserve University

    Cleveland, Ohio 44106
    United States

    Site Not Available

  • Cleveland Clinic Cancer Center/Fairview Hospital

    Cleveland, Ohio 44111
    United States

    Site Not Available

  • Cleveland Clinic Foundation

    Cleveland, Ohio 44195
    United States

    Site Not Available

  • MetroHealth Medical Center

    Cleveland, Ohio 44109
    United States

    Site Not Available

  • Ohio State University Comprehensive Cancer Center

    Columbus, Ohio 43210
    United States

    Site Not Available

  • Riverside Methodist Hospital

    Columbus, Ohio 43214
    United States

    Site Not Available

  • Kettering Medical Center

    Kettering, Ohio 45429
    United States

    Site Not Available

  • Hillcrest Hospital Cancer Center

    Mayfield Heights, Ohio 44124
    United States

    Site Not Available

  • Lake University Ireland Cancer Center

    Mentor, Ohio 44060
    United States

    Site Not Available

  • University of Oklahoma Health Sciences Center

    Oklahoma City, Oklahoma 73104
    United States

    Site Not Available

  • Tulsa Cancer Institute

    Tulsa, Oklahoma 74146
    United States

    Site Not Available

  • Abington Memorial Hospital

    Abington, Pennsylvania 19001
    United States

    Site Not Available

  • Lehigh Valley Hospital-Cedar Crest

    Allentown, Pennsylvania 18103
    United States

    Site Not Available

  • Geisinger Medical Center

    Danville, Pennsylvania 17822
    United States

    Site Not Available

  • Geisinger Medical Center-Cancer Center Hazleton

    Hazleton, Pennsylvania 18201
    United States

    Site Not Available

  • Penn State Milton S Hershey Medical Center

    Hershey, Pennsylvania 17033-0850
    United States

    Site Not Available

  • Fox Chase Cancer Center

    Philadelphia, Pennsylvania 19111
    United States

    Site Not Available

  • Pennsylvania Hospital

    Philadelphia, Pennsylvania 19107
    United States

    Site Not Available

  • UPMC-Magee Womens Hospital

    Pittsburgh, Pennsylvania 15213
    United States

    Site Not Available

  • West Penn Hospital

    Pittsburgh, Pennsylvania 15224
    United States

    Site Not Available

  • McGlinn Family Regional Cancer Center at Reading Hospital and Medical Center

    Reading, Pennsylvania 19612-6052
    United States

    Site Not Available

  • Geisinger Medical Group

    State College, Pennsylvania 16801
    United States

    Site Not Available

  • Reading Hospital

    West Reading, Pennsylvania 19611
    United States

    Site Not Available

  • Geisinger Wyoming Valley/Henry Cancer Center

    Wilkes-Barre, Pennsylvania 18711
    United States

    Site Not Available

  • Women and Infants Hospital

    Providence, Rhode Island 02905
    United States

    Site Not Available

  • Medical University of South Carolina

    Charleston, South Carolina 29425
    United States

    Site Not Available

  • Avera Cancer Institute

    Sioux Falls, South Dakota 57105
    United States

    Site Not Available

  • Sanford Cancer Center-Oncology Clinic

    Sioux Falls, South Dakota 57104
    United States

    Site Not Available

  • Sanford USD Medical Center - Sioux Falls

    Sioux Falls, South Dakota 57117-5134
    United States

    Site Not Available

  • Vanderbilt-Ingram Cancer Center

    Nashville, Tennessee 37232
    United States

    Site Not Available

  • Clements University Hospital

    Dallas, Texas 75390
    United States

    Site Not Available

  • Parkland Memorial Hospital

    Dallas, Texas 75235
    United States

    Site Not Available

  • UT Southwestern/Simmons Cancer Center-Dallas

    Dallas, Texas 75390
    United States

    Site Not Available

  • Zale Lipshy University Hospital

    Dallas, Texas 75235
    United States

    Site Not Available

  • Baylor All Saints Medical Center at Fort Worth

    Fort Worth, Texas 76104
    United States

    Site Not Available

  • M D Anderson Cancer Center

    Houston, Texas 77030
    United States

    Site Not Available

  • Huntsman Cancer Institute/University of Utah

    Salt Lake City, Utah 84112
    United States

    Site Not Available

  • University of Vermont Medical Center

    Burlington, Vermont 05401
    United States

    Site Not Available

  • University of Wisconsin Hospital and Clinics

    Madison, Wisconsin 53792
    United States

    Site Not Available

  • Aurora Saint Luke's Medical Center

    Milwaukee, Wisconsin 53215
    United States

    Site Not Available

  • Cancer Center of Western Wisconsin

    New Richmond, Wisconsin 54017
    United States

    Site Not Available

  • Aurora Women's Pavilion of Aurora West Allis Medical Center

    West Allis, Wisconsin 53227
    United States

    Site Not Available

Not the study for you?

Let us help you find the best match. Sign up as a volunteer and receive email notifications when clinical trials are posted in the medical category of interest to you.