Phase
Condition
Diabetes (Pediatric)
Reproductive Health
Diabetes And Hypertension
Treatment
N/AClinical Study ID
Ages 18-40 Female
Study Summary
Eligibility Criteria
Inclusion
Inclusion Criteria:
age < 40 years at entry
BMI > 19 kg/m2
Infertility lasting > 1 year
Criteria for PCOS are as defined by ESHRE/ASRM: at least two of the followingfindings:
polycystic ovaries shown by vaginal ultrasonography (more than 12 subcapsularfollicles of 3-8 mm diameter in one plane of the ovary)
oligomenorrhea or amenorrhea
clinical manifestations of hyperandrogenism such as a hirsutism score of > 7according to Ferriman and Gallwey (Ferriman & Gallwey 1961)and/or an elevatedserum testosterone level (> 2.7 nmol/l).
Exclusion
Exclusion Criteria:
diabetic subjects
alcohol users
active liver disease (ALAT > +2 SD the upper normal value i.e.> 100IU/l)
hormonal drugs
past or present cardiac failure (NYHA I-IV)
liver or renal failure (S-Creatinine above the normal value ie.124 umol/l)
pregnancy or lactation
hypersensitivity to metformin
Study Design
Study Description
Connect with a study center
University Hospital Of Helsinki
Helsinki,
FinlandSite Not Available
University Hospital of Kuopio
Kuopio,
FinlandSite Not Available
University Hopsital of Oulu
Oulu, 90029
FinlandSite Not Available
University Hospital of Tampere
Tampere,
FinlandSite Not Available
University Hospital of Turku
Turku,
FinlandSite Not Available
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