Glutathione in Preventing Peripheral Neuropathy Caused by Paclitaxel and Carboplatin in Patients With Ovarian Cancer, Fallopian Tube Cancer, and/or Primary Peritoneal Cancer

Last updated: December 13, 2011
Sponsor: North Central Cancer Treatment Group
Overall Status: Active - Not Recruiting

Phase

3

Condition

Pain

Ovarian Cancer

Peripheral Neuropathy

Treatment

N/A

Clinical Study ID

NCT00979082
CDR0000654097
NCCTG-N08CA
  • Ages > 18
  • Female

Study Summary

RATIONALE: Drugs used in chemotherapy work in different ways to stop the growth of cancer cells, either by killing the cells or by stopping them from dividing. Chemoprotective drugs, such as glutathione, may help prevent peripheral neuropathy caused by paclitaxel and carboplatin. It is not yet known whether glutathione is more effective than a placebo in preventing peripheral neuropathy.

PURPOSE: This randomized phase III trial is studying glutathione to see how well it works in preventing peripheral neuropathy caused by paclitaxel and carboplatin in patients with ovarian cancer, fallopian tube cancer, and/or primary peritoneal cancer.

Eligibility Criteria

Inclusion

DISEASE CHARACTERISTICS:

  • Diagnosis of stage III/IV ovarian cancer, fallopian tube cancer, and/or primary peritoneal carcinoma

  • Scheduled to undergo treatment with paclitaxel at 175 mg/m^2 and carboplatin at area under the curve = 6 every 21 days for 6 courses with or without bevacizumab

PATIENT CHARACTERISTICS:

  • ECOG performance status 0-2

  • Life expectancy ≥ 6 months

  • WBC ≥ 3,400/mm^3

  • ANC ≥ 1,500/mm^3

  • Platelet count ≥ 100,000/mm^3

  • Hemoglobin > 10.0 g/dL

  • Creatinine ≤ 1.5 times upper limit of normal

  • Not pregnant or nursing

  • Negative pregnancy test

  • Fertile patients must use effective contraception

  • Able to complete English language questionnaire(s) alone or with assistance

  • Willing to provide blood specimens as required by the study

  • No pre-existing history of peripheral neuropathy > grade 1 (NCI CTCAE v4.0) due to any cause (e.g., chemotherapy, diabetes, alcohol, toxin, or heredity)

  • No other medical conditions that, in the opinion of the treating physician/allied health professional, would make this study unreasonably hazardous for the patient

PRIOR CONCURRENT THERAPY:

  • See Disease Characteristics

  • No prior paclitaxel or carboplatin other than the current treatment regimen

  • No other concurrent treatment for the prevention of peripheral neuropathy, including prescription and over-the-counter or herbal therapies

Study Design

Total Participants: 186
Study Start date:
December 01, 2009
Estimated Completion Date:

Study Description

OBJECTIVES:

Primary

  • To compare paclitaxel/carboplatin (PC)-induced (PCI) peripheral neuropathy (PN) as measured by EORTC-QLQ-CIPN20 between patients with ovarian cancer and/or primary peritoneal carcinoma treated with glutathione vs placebo.

Secondary

  • To compare the incidences of grade 2+ and grade 3+ PCI PN as measured by CTCAE neuropathy scale between the glutathione and placebo arms.

  • To compare the time to onset of grade 2+ and grade 3+ PCI PN between the treatment arms as measured by CTCAE neuropathy scale.

  • To compare the proportion of patients requiring chemotherapy dose reductions secondary to PCI PN between the treatment arms.

  • To compare the proportion of patients stopping PC secondary to peripheral neuropathy between the arms.

  • To assess the toxicity profile of glutathione in this situation.

  • To evaluate whether glutathione influences the antitumor activity of PC.

  • To evaluate patient quality of life as measured by FACT-O and patient daily-symptom questionnaires over time between the treatment arms.

Tertiary (exploratory)

  • To explore the association of genetic variations in genes involved in taxane/platinum metabolism with the incidence of grade 2+ PCI PN.

  • To bank blood products for future studies.

OUTLINE: Patients are stratified according to baseline neuropathy (none vs grade 1), age (≤ 50 years vs > 50 years), debulked status (no gross residual disease [no clinically apparent residual lesions at the completion of primary surgery] vs optimal [largest residual lesion < 1 cm at primary surgery] vs sub-optimally debulked [residual lesion > 1 cm] or not operated upon), concurrent use of bevacizumab (yes vs no), paclitaxel planned dose (weekly vs every 3 weeks), and diabetes requiring insulin or oral hypoglycemic medications (yes vs no). Patients are randomized to 1 of 2 treatment arms.

Ideally, patients begin receiving glutathione before their first dose of chemotherapy, but must begin glutathione before their second dose of chemotherapy.

  • Arm I: Patients receive glutathione IV over 15 minutes, paclitaxel* IV over 3 hours, and carboplatin IV over 30 minutes on day 1. Treatment repeats every 21-28 days for at least 12 weeks in the absence of disease progression or unacceptable toxicity.

  • Arm II: Patients receive placebo IV over 15 minutes, paclitaxel* IV over 3 hours, and carboplatin IV over 30 minutes as in arm I.

NOTE: * Alternatively, patients may receive paclitaxel IV over 1 hour and glutathione/placebo IV over 15 minutes weekly and carboplatin every 21 days for 12 weeks.

Blood samples are collected periodically for pharmacogenomic and other biomarker analyses. Patients complete questionnaires periodically, including quality-of-life assessments.

After completion of study treatment, patients are followed up every 3 months for 1 year.

Connect with a study center

  • Providence Cancer Center at Providence Hospital

    Mobile, Alabama 36608
    United States

    Site Not Available

  • Fairbanks Cancer Treatment Center at Fairbanks Memorial Hospital

    Fairbanks, Alaska 99701
    United States

    Site Not Available

  • Mayo Clinic Scottsdale

    Scottsdale, Arizona 85259-5499
    United States

    Site Not Available

  • North Bay Cancer Center

    Fairfield, California 94533
    United States

    Site Not Available

  • Cancer Care Associates

    Fresno, California 93720
    United States

    Site Not Available

  • Chao Family Comprehensive Cancer Center at University of California Irvine Medical Center

    Orange, California 92868
    United States

    Site Not Available

  • St. Joseph Hospital Regional Cancer Center - Orange

    Orange, California 92868
    United States

    Site Not Available

  • Feather River Hospital Cancer Center

    Paradise, California 95969
    United States

    Site Not Available

  • Sutter Cancer Center at Roseville Medical Center

    Roseville, California 95661
    United States

    Site Not Available

  • Sutter Cancer Center

    Sacramento, California 95816
    United States

    Site Not Available

  • Aurora Presbyterian Hospital

    Aurora, Colorado 80012
    United States

    Site Not Available

  • Boulder Community Hospital

    Boulder, Colorado 80301-9019
    United States

    Site Not Available

  • Penrose Cancer Center at Penrose Hospital

    Colorado Springs, Colorado 80933
    United States

    Site Not Available

  • CCOP - Colorado Cancer Research Program

    Denver, Colorado 80224-2522
    United States

    Site Not Available

  • Porter Adventist Hospital

    Denver, Colorado 80210
    United States

    Site Not Available

  • Presbyterian - St. Luke's Medical Center

    Denver, Colorado 80218
    United States

    Site Not Available

  • Rose Medical Center

    Denver, Colorado 80220
    United States

    Site Not Available

  • St. Anthony Central Hospital

    Denver, Colorado 80204
    United States

    Site Not Available

  • St. Joseph Hospital

    Denver, Colorado 80218
    United States

    Site Not Available

  • Swedish Medical Center

    Englewood, Colorado 80110
    United States

    Site Not Available

  • Front Range Cancer Specialists

    Fort Collins, Colorado 80528
    United States

    Site Not Available

  • Poudre Valley Hospital

    Fort Collins, Colorado 80524
    United States

    Site Not Available

  • St. Mary's Regional Cancer Center at St. Mary's Hospital and Medical Center

    Grand Junction, Colorado 81502
    United States

    Site Not Available

  • North Colorado Medical Center

    Greeley, Colorado 80631
    United States

    Site Not Available

  • Sky Ridge Medical Center

    Lone Tree, Colorado 80124
    United States

    Site Not Available

  • Hope Cancer Care Center at Longmont United Hospital

    Longmont, Colorado 80501
    United States

    Site Not Available

  • McKee Medical Center

    Loveland, Colorado 80539
    United States

    Site Not Available

  • St. Mary - Corwin Regional Medical Center

    Pueblo, Colorado 81004
    United States

    Site Not Available

  • North Suburban Medical Center

    Thornton, Colorado 80229
    United States

    Site Not Available

  • Exempla Lutheran Medical Center

    Wheat Ridge, Colorado 80033
    United States

    Site Not Available

  • Bendheim Cancer Center at Greenwich Hospital

    Greenwich, Connecticut 06830
    United States

    Site Not Available

  • Saint Francis/Mount Sinai Regional Cancer Center at Saint Francis Hospital and Medical Center

    Hartford, Connecticut 06105
    United States

    Site Not Available

  • Herbert D. Kerman Regional Oncology Center - Daytona Beach

    Daytona Beach, Florida 32114
    United States

    Site Not Available

  • Mayo Clinic - Jacksonville

    Jacksonville, Florida 32224
    United States

    Site Not Available

  • Phoebe Cancer Center at Phoebe Putney Memorial Hospital

    Albany, Georgia 31701
    United States

    Site Not Available

  • CCOP - Atlanta Regional

    Atlanta, Georgia 30342
    United States

    Site Not Available

  • Northside Hospital Cancer Center

    Atlanta, Georgia 30342-1611
    United States

    Site Not Available

  • Piedmont Hospital

    Atlanta, Georgia 30309
    United States

    Site Not Available

  • Saint Joseph's Hospital of Atlanta

    Atlanta, Georgia 30342-1701
    United States

    Site Not Available

  • MBCCOP - Medical College of Georgia Cancer Center

    Augusta, Georgia 30912
    United States

    Site Not Available

  • WellStar Cobb Hospital

    Austell, Georgia 30106
    United States

    Site Not Available

  • John B. Amos Cancer Center

    Columbus, Georgia 31904
    United States

    Site Not Available

  • Charles B. Eberhart Cancer Center at DeKalb Medical Center

    Decatur, Georgia 30033
    United States

    Site Not Available

  • Northeast Georgia Medical Center

    Gainesville, Georgia 30501
    United States

    Site Not Available

  • Gwinnett Medical Center

    Lawrenceville, Georgia 30045
    United States

    Site Not Available

  • Kennestone Cancer Center at Wellstar Kennestone Hospital

    Marietta, Georgia 30060
    United States

    Site Not Available

  • Southern Regional Medical Center

    Riverdale, Georgia 30274-2600
    United States

    Site Not Available

  • Harbin Clinic Cancer Center - Medical Oncology

    Rome, Georgia 30165
    United States

    Site Not Available

  • Nancy N. and J. C. Lewis Cancer and Research Pavilion at St. Joseph's/Candler

    Savannah, Georgia 31405
    United States

    Site Not Available

  • Kapiolani Medical Center at Pali Momi

    Aiea, Hawaii 96701
    United States

    Site Not Available

  • Cancer Research Center of Hawaii

    Honolulu, Hawaii 96813
    United States

    Site Not Available

  • Hawaii Medical Center - East

    Honolulu, Hawaii 96817
    United States

    Site Not Available

  • Kapiolani Medical Center for Women and Children

    Honolulu, Hawaii 96826
    United States

    Site Not Available

  • OnCare Hawaii, Incorporated - Kuakini

    Honolulu, Hawaii 96817
    United States

    Site Not Available

  • OnCare Hawaii, Incorporated - Lusitana

    Honolulu, Hawaii 96813
    United States

    Site Not Available

  • Queen's Cancer Institute at Queen's Medical Center

    Honolulu, Hawaii 96813
    United States

    Site Not Available

  • Straub Clinic and Hospital, Incorporated

    Honolulu, Hawaii 96813
    United States

    Site Not Available

  • Kauai Medical Clinic

    Lihue, Hawaii 96766
    United States

    Site Not Available

  • Maui Memorial Medical Center

    Wailuku, Hawaii 96793
    United States

    Site Not Available

  • Pacific Cancer Institute - Maui

    Wailuku, Hawaii 96793
    United States

    Site Not Available

  • St. Joseph Medical Center

    Bloomington, Illinois 61701
    United States

    Site Not Available

  • Illinois CancerCare - Bloomington

    Bloomington%, Illinois 61701
    United States

    Site Not Available

  • Illinois CancerCare - Canton

    Canton, Illinois 61520
    United States

    Site Not Available

  • Illinois CancerCare - Carthage

    Carthage, Illinois 62321
    United States

    Site Not Available

  • Resurrection Medical Center

    Chicago, Illinois 60631
    United States

    Site Not Available

  • Decatur Memorial Hospital Cancer Care Institute

    Decatur, Illinois 62526
    United States

    Site Not Available

  • Eureka Community Hospital

    Eureka, Illinois 61530
    United States

    Site Not Available

  • Galesburg Clinic, PC

    Galesburg, Illinois 61401
    United States

    Site Not Available

  • Ingalls Cancer Care Center at Ingalls Memorial Hospital

    Harvey, Illinois 60426
    United States

    Site Not Available

  • Illinois CancerCare - Havana

    Havana, Illinois 62644
    United States

    Site Not Available

  • Illinois CancerCare - Kewanee Clinic

    Kewanee, Illinois 61443
    United States

    Site Not Available

  • La Grange Memorial Hospital

    La Grange, Illinois 60525
    United States

    Site Not Available

  • McDonough District Hospital

    Macomb, Illinois 61455
    United States

    Site Not Available

  • Cardinal Bernardin Cancer Center at Loyola University Medical Center

    Maywood, Illinois 60153
    United States

    Site Not Available

  • Trinity Cancer Center at Trinity Medical Center - 7th Street Campus

    Moline, Illinois 61265
    United States

    Site Not Available

  • Moline, Illinois 61265
    United States

    Site Not Available

  • Illinois CancerCare - Monmouth

    Monmouth, Illinois 61462
    United States

    Site Not Available

  • Illinois CancerCare - Community Cancer Center

    Normal, Illinois 61761
    United States

    Site Not Available

  • Oncology Hematology Associates of Central Illinois, PC - Ottawa

    Ottawa, Illinois 61350
    United States

    Site Not Available

  • Illinois CancerCare - Pekin

    Pekin, Illinois 61603
    United States

    Site Not Available

  • CCOP - Illinois Oncology Research Association

    Peoria, Illinois 61615
    United States

    Site Not Available

  • Illinois CancerCare - Peru

    Peru, Illinois 61354
    United States

    Site Not Available

  • Illinois CancerCare - Princeton

    Princeton, Illinois 61356
    United States

    Site Not Available

  • Illinois CancerCare - Spring Valley

    Spring Valley, Illinois 61362
    United States

    Site Not Available

  • Regional Cancer Center at Memorial Medical Center

    Springfield, Illinois 62781-0001
    United States

    Site Not Available

  • CCOP - Carle Cancer Center

    Urbana, Illinois 61801
    United States

    Site Not Available

  • St. Francis Hospital and Health Centers - Beech Grove Campus

    Beech Grove, Indiana 46107
    United States

    Site Not Available

  • Elkhart Clinic, LLC

    Elkhart, Indiana 46514-2098
    United States

    Site Not Available

  • Elkhart General Hospital

    Elkhart, Indiana 46515
    United States

    Site Not Available

  • Michiana Hematology-Oncology, PC - Elkhart

    Elkhart, Indiana 46514
    United States

    Site Not Available

  • Howard Community Hospital

    Kokomo, Indiana 46904
    United States

    Site Not Available

  • Center for Cancer Therapy at LaPorte Hospital and Health Services

    La Porte, Indiana 46350
    United States

    Site Not Available

  • Clarian Arnett Cancer Care

    Lafayette, Indiana 47904
    United States

    Site Not Available

  • Saint Anthony Memorial Health Centers

    Michigan City, Indiana 46360
    United States

    Site Not Available

  • Michiana Hematology-Oncology, PC - South Bend

    Mishawaka, Indiana 46545-1470
    United States

    Site Not Available

  • Saint Joseph Regional Medical Center

    Mishawaka, Indiana 46545-1470
    United States

    Site Not Available

  • Michiana Hematology Oncology PC - Plymouth

    Plymouth, Indiana 46563
    United States

    Site Not Available

  • Reid Hospital & Health Care Services

    Richmond, Indiana 47374
    United States

    Site Not Available

  • CCOP - Northern Indiana CR Consortium

    South Bend, Indiana 46601
    United States

    Site Not Available

  • Memorial Hospital of South Bend

    South Bend, Indiana 46601
    United States

    Site Not Available

  • Michiana Hematology Oncology PC - La Porte

    Westville, Indiana 46391
    United States

    Site Not Available

  • McFarland Clinic, PC

    Ames, Iowa 50010
    United States

    Site Not Available

  • Hematology Oncology Associates of the Quad Cities

    Bettendorf, Iowa 52722
    United States

    Site Not Available

  • Bettendorf, Iowa 52722
    United States

    Site Not Available

  • Cedar Rapids Oncology Associates

    Cedar Rapids, Iowa 52403
    United States

    Site Not Available

  • Mercy Regional Cancer Center at Mercy Medical Center

    Cedar Rapids, Iowa 52403
    United States

    Site Not Available

  • Medical Oncology and Hematology Associates - West Des Moines

    Clive, Iowa 50325
    United States

    Site Not Available

  • CCOP - Iowa Oncology Research Association

    Des Moines, Iowa 50309
    United States

    Site Not Available

  • John Stoddard Cancer Center at Iowa Lutheran Hospital

    Des Moines, Iowa 50316
    United States

    Site Not Available

  • John Stoddard Cancer Center at Iowa Methodist Medical Center

    Des Moines, Iowa 50309
    United States

    Site Not Available

  • Medical Oncology and Hematology Associates at John Stoddard Cancer Center

    Des Moines, Iowa 50309
    United States

    Site Not Available

  • Medical Oncology and Hematology Associates at Mercy Cancer Center

    Des Moines, Iowa 50314
    United States

    Site Not Available

  • Mercy Cancer Center at Mercy Medical Center - Des Moines

    Des Moines, Iowa 50314
    United States

    Site Not Available

  • McCreery Cancer Center at Ottumwa Regional

    Ottumwa, Iowa 52501
    United States

    Site Not Available

  • Mercy Medical Center - Sioux City

    Sioux City, Iowa 51102
    United States

    Site Not Available

  • Siouxland Hematology-Oncology Associates, LLP

    Sioux City, Iowa 51101
    United States

    Site Not Available

  • St. Luke's Regional Medical Center

    Sioux City, Iowa 51104
    United States

    Site Not Available

  • Cancer Center of Kansas, PA - Chanute

    Chanute, Kansas 66720
    United States

    Site Not Available

  • Cancer Center of Kansas, PA - Dodge City

    Dodge City, Kansas 67801
    United States

    Site Not Available

  • Cancer Center of Kansas, PA - El Dorado

    El Dorado, Kansas 67042
    United States

    Site Not Available

  • Cancer Center of Kansas - Fort Scott

    Fort Scott, Kansas 66701
    United States

    Site Not Available

  • Cancer Center of Kansas-Independence

    Independence, Kansas 67301
    United States

    Site Not Available

  • Cancer Center of Kansas, PA - Kingman

    Kingman, Kansas 67068
    United States

    Site Not Available

  • Lawrence Memorial Hospital

    Lawrence, Kansas 66044
    United States

    Site Not Available

  • Cancer Center of Kansas, PA - Liberal

    Liberal, Kansas 67901
    United States

    Site Not Available

  • Cancer Center of Kansas, PA - McPherson

    McPherson, Kansas 67460
    United States

    Site Not Available

  • Cancer Center of Kansas, PA - Newton

    Newton, Kansas 67114
    United States

    Site Not Available

  • Menorah Medical Center

    Overland Park, Kansas 66209
    United States

    Site Not Available

  • Saint Luke's Hospital - South

    Overland Park, Kansas 66213
    United States

    Site Not Available

  • Cancer Center of Kansas, PA - Parsons

    Parsons, Kansas 67357
    United States

    Site Not Available

  • CCOP - Kansas City

    Prairie Village, Kansas 66208
    United States

    Site Not Available

  • Cancer Center of Kansas, PA - Pratt

    Pratt, Kansas 67124
    United States

    Site Not Available

  • Cancer Center of Kansas, PA - Salina

    Salina, Kansas 67401
    United States

    Site Not Available

  • Cancer Center of Kansas, PA - Wellington

    Wellington, Kansas 67152
    United States

    Site Not Available

  • Associates in Womens Health, PA - North Review

    Wichita, Kansas 67208
    United States

    Site Not Available

  • CCOP - Wichita

    Wichita, Kansas 67214
    United States

    Site Not Available

  • Cancer Center of Kansas, PA - Medical Arts Tower

    Wichita, Kansas 67208
    United States

    Site Not Available

  • Cancer Center of Kansas, PA - Wichita

    Wichita, Kansas 67214
    United States

    Site Not Available

  • Via Christi Cancer Center at Via Christi Regional Medical Center

    Wichita, Kansas 67214
    United States

    Site Not Available

  • Cancer Center of Kansas, PA - Winfield

    Winfield, Kansas 67156
    United States

    Site Not Available

  • Ochsner Health Center - Bluebonnet

    Baton Rouge, Louisiana 70809
    United States

    Site Not Available

  • Ochsner Health Center - Covington

    Covington, Louisiana 70433
    United States

    Site Not Available

  • Louisiana State University Health Sciences Center - Monroe

    Monroe, Louisiana 71210
    United States

    Site Not Available

  • CCOP - Ochsner

    New Orleans, Louisiana 70121
    United States

    Site Not Available

  • Ochsner Cancer Institute at Ochsner Clinic Foundation

    New Orleans, Louisiana 70121
    United States

    Site Not Available

  • Feist-Weiller Cancer Center at Louisiana State University Health Sciences

    Shreveport, Louisiana 71130-3932
    United States

    Site Not Available

  • Highland Clinic

    Shreveport, Louisiana 71105
    United States

    Site Not Available

  • Harold Alfond Center for Cancer Care

    Augusta, Maine 04330
    United States

    Site Not Available

  • CancerCare of Maine at Eastern Maine Medical Center

    Bangor, Maine 04401
    United States

    Site Not Available

  • Shore Regional Cancer Center at Memorial Hospital - Easton

    Easton, Maryland 21601
    United States

    Site Not Available

  • CCOP - Michigan Cancer Research Consortium

    Ann Arbor, Michigan 48106
    United States

    Site Not Available

  • Saint Joseph Mercy Cancer Center

    Ann Arbor, Michigan 48106-0995
    United States

    Site Not Available

  • Oakwood Cancer Center at Oakwood Hospital and Medical Center

    Dearborn, Michigan 48123-2500
    United States

    Site Not Available

  • Green Bay Oncology, Limited - Escanaba

    Escanaba, Michigan 49431
    United States

    Site Not Available

  • Genesys Hurley Cancer Institute

    Flint, Michigan 48503
    United States

    Site Not Available

  • Hurley Medical Center

    Flint, Michigan 48503
    United States

    Site Not Available

  • Van Elslander Cancer Center at St. John Hospital and Medical Center

    Grosse Pointe Woods, Michigan 48236
    United States

    Site Not Available

  • Dickinson County Healthcare System

    Iron Mountain, Michigan 49801
    United States

    Site Not Available

  • Foote Memorial Hospital

    Jackson, Michigan 49201
    United States

    Site Not Available

  • Borgess Medical Center

    Kalamazoo, Michigan 49001
    United States

    Site Not Available

  • Bronson Methodist Hospital

    Kalamazoo, Michigan 49007
    United States

    Site Not Available

  • West Michigan Cancer Center

    Kalamazoo, Michigan 49007-3731
    United States

    Site Not Available

  • Sparrow Regional Cancer Center

    Lansing, Michigan 48912-1811
    United States

    Site Not Available

  • St. Mary Mercy Hospital

    Livonia, Michigan 48154
    United States

    Site Not Available

  • Clemens Regional Medical Center

    Mount Clemens, Michigan 48043
    United States

    Site Not Available

  • Michiana Hematology Oncology PC - Niles

    Niles, Michigan 49120
    United States

    Site Not Available

  • St. Joseph Mercy Oakland

    Pontiac, Michigan 48341-2985
    United States

    Site Not Available

  • Mercy Regional Cancer Center at Mercy Hospital

    Port Huron, Michigan 48060
    United States

    Site Not Available

  • Seton Cancer Institute at Saint Mary's - Saginaw

    Saginaw, Michigan 48601
    United States

    Site Not Available

  • Lakeside Cancer Specialists, PLLC

    Saint Joseph, Michigan 49085
    United States

    Site Not Available

  • Providence Cancer Institute at Providence Hospital - Southfield Campus

    Southfield, Michigan 48075
    United States

    Site Not Available

  • Lakeland Regional Cancer Care Center - St. Joseph

    St. Joseph, Michigan 49085
    United States

    Site Not Available

  • St. John Macomb Hospital

    Warren, Michigan 48093
    United States

    Site Not Available

  • Alexandria, Minnesota 56308
    United States

    Site Not Available

  • Fairview Ridges Hospital

    Burnsville, Minnesota 55337
    United States

    Site Not Available

  • Mercy and Unity Cancer Center at Mercy Hospital

    Coon Rapids, Minnesota 55433
    United States

    Site Not Available

  • CCOP - Duluth

    Duluth, Minnesota 55805
    United States

    Site Not Available

  • Duluth Clinic Cancer Center - Duluth

    Duluth, Minnesota 55805-1983
    United States

    Site Not Available

  • Miller - Dwan Medical Center

    Duluth, Minnesota 55805
    United States

    Site Not Available

  • Fairview Southdale Hospital

    Edina, Minnesota 55435
    United States

    Site Not Available

  • Mercy and Unity Cancer Center at Unity Hospital

    Fridley, Minnesota 55432
    United States

    Site Not Available

  • Hutchinson Area Health Care

    Hutchinson, Minnesota 55350
    United States

    Site Not Available

  • Immanuel St. Joseph's

    Mankato, Minnesota 56002
    United States

    Site Not Available

  • HealthEast Cancer Care at St. John's Hospital

    Maplewood, Minnesota 55109
    United States

    Site Not Available

  • Minnesota Oncology Hematology, PA - Maplewood

    Maplewood, Minnesota 55109
    United States

    Site Not Available

  • Hennepin County Medical Center - Minneapolis

    Minneapolis, Minnesota 55415
    United States

    Site Not Available

  • Veterans Affairs Medical Center - Minneapolis

    Minneapolis, Minnesota 55417
    United States

    Site Not Available

  • Virginia Piper Cancer Institute at Abbott - Northwestern Hospital

    Minneapolis, Minnesota 55407
    United States

    Site Not Available

  • Humphrey Cancer Center at North Memorial Outpatient Center

    Robbinsdale, Minnesota 55422-2900
    United States

    Site Not Available

  • Mayo Clinic Cancer Center

    Rochester, Minnesota 55905
    United States

    Site Not Available

  • CentraCare Clinic - River Campus

    Saint Cloud, Minnesota 56303
    United States

    Site Not Available

  • Coborn Cancer Center

    Saint Cloud, Minnesota 56303
    United States

    Site Not Available

  • CCOP - Metro-Minnesota

    Saint Louis Park, Minnesota 55416
    United States

    Site Not Available

  • Park Nicollet Cancer Center

    Saint Louis Park, Minnesota 55416
    United States

    Site Not Available

  • United Hospital

    Saint Paul, Minnesota 55102
    United States

    Site Not Available

  • St. Francis Cancer Center at St. Francis Medical Center

    Shakopee, Minnesota 55379
    United States

    Site Not Available

  • Regions Hospital Cancer Care Center

    St. Paul, Minnesota 55101
    United States

    Site Not Available

  • Lakeview Hospital

    Stillwater, Minnesota 55082
    United States

    Site Not Available

  • Ridgeview Medical Center

    Waconia, Minnesota 55387
    United States

    Site Not Available

  • Willmar Cancer Center at Rice Memorial Hospital

    Willmar, Minnesota 56201
    United States

    Site Not Available

  • Minnesota Oncology Hematology, PA - Woodbury

    Woodbury, Minnesota 55125
    United States

    Site Not Available

  • Heartland Hematology Oncology Associates, Incorporated

    Kansas City, Missouri 64118
    United States

    Site Not Available

  • North Kansas City Hospital

    Kansas City, Missouri 64116
    United States

    Site Not Available

  • Parvin Radiation Oncology

    Kansas City, Missouri 64116
    United States

    Site Not Available

  • Research Medical Center

    Kansas City, Missouri 64132
    United States

    Site Not Available

  • Saint Luke's Cancer Institute at Saint Luke's Hospital

    Kansas City, Missouri 64111
    United States

    Site Not Available

  • St. Joseph Medical Center

    Kansas City, Missouri 64114
    United States

    Site Not Available

  • Saint Luke's East - Lee's Summit

    Lee's Summit, Missouri 64086
    United States

    Site Not Available

  • Liberty Hospital

    Liberty, Missouri 64068
    United States

    Site Not Available

  • Heartland Regional Medical Center

    Saint Joseph, Missouri 64506
    United States

    Site Not Available

  • Saint Joseph Oncology, Incorporated

    Saint Joseph, Missouri 64507
    United States

    Site Not Available

  • CCOP - Cancer Research for the Ozarks

    Springfield, Missouri 65802
    United States

    Site Not Available

  • Hulston Cancer Center at Cox Medical Center South

    Springfield, Missouri 65807
    United States

    Site Not Available

  • St. John's Regional Health Center

    Springfield, Missouri 65804
    United States

    Site Not Available

  • Billings Clinic - Downtown

    Billings, Montana 59107-7000
    United States

    Site Not Available

  • CCOP - Montana Cancer Consortium

    Billings, Montana 59101
    United States

    Site Not Available

  • Hematology-Oncology Centers of the Northern Rockies - Billings

    Billings, Montana 59102
    United States

    Site Not Available

  • St. Vincent Healthcare Cancer Care Services

    Billings, Montana 59101
    United States

    Site Not Available

  • Bozeman Deaconess Cancer Center

    Bozeman, Montana 59715
    United States

    Site Not Available

  • St. James Healthcare Cancer Care

    Butte, Montana 59701
    United States

    Site Not Available

  • Big Sky Oncology

    Great Falls, Montana 59405-5309
    United States

    Site Not Available

  • Great Falls Clinic - Main Facility

    Great Falls, Montana 59405
    United States

    Site Not Available

  • Sletten Cancer Institute at Benefis Healthcare

    Great Falls, Montana 59405
    United States

    Site Not Available

  • Northern Montana Hospital

    Havre, Montana 59501
    United States

    Site Not Available

  • St. Peter's Hospital

    Helena, Montana 59601
    United States

    Site Not Available

  • Glacier Oncology, PLLC

    Kalispell, Montana 59901
    United States

    Site Not Available

  • Kalispell Medical Oncology at KRMC

    Kalispell, Montana 59901
    United States

    Site Not Available

  • Kalispell Regional Medical Center

    Kalispell, Montana 59901
    United States

    Site Not Available

  • Montana Cancer Center at St. Patrick Hospital and Health Sciences Center

    Missoula, Montana 59807
    United States

    Site Not Available

  • Montana Cancer Specialists at Montana Cancer Center

    Missoula, Montana 59807-7877
    United States

    Site Not Available

  • Cancer Resource Center - Lincoln

    Lincoln, Nebraska 68510
    United States

    Site Not Available

  • Alegant Health Cancer Center at Bergan Mercy Medical Center

    Omaha, Nebraska 68124
    United States

    Site Not Available

  • CCOP - Missouri Valley Cancer Consortium

    Omaha, Nebraska 68106
    United States

    Site Not Available

  • Creighton University Medical Center

    Omaha, Nebraska 68131-2197
    United States

    Site Not Available

  • Immanuel Medical Center

    Omaha, Nebraska 68122
    United States

    Site Not Available

  • CCOP - Nevada Cancer Research Foundation

    Las Vegas, Nevada 89106
    United States

    Site Not Available

  • University Medical Center of Southern Nevada

    Las Vegas, Nevada 89102
    United States

    Site Not Available

  • Seacoast Cancer Center at Wentworth - Douglass Hospital

    Dover, New Hampshire 03820
    United States

    Site Not Available

  • Oncology Center at St. Joseph Hospital

    Nashua, New Hampshire 03060
    United States

    Site Not Available

  • Somerset Medical Center

    Somerville, New Jersey 08876
    United States

    Site Not Available

  • Charles R. Wood Cancer Center at Glens Falls Hospital

    Glens Falls, New York 12801
    United States

    Site Not Available

  • Nalitt Cancer Institute at Staten Island University Hospital

    Staten Island, New York 10305
    United States

    Site Not Available

  • Randolph Hospital

    Asheboro, North Carolina 27203-5400
    United States

    Site Not Available

  • Wayne Memorial Hospital, Incorporated

    Goldsboro, North Carolina 27534
    United States

    Site Not Available

  • Moses Cone Regional Cancer Center at Wesley Long Community Hospital

    Greensboro, North Carolina 27403-1198
    United States

    Site Not Available

  • Pardee Memorial Hospital

    Hendersonville, North Carolina 28791
    United States

    Site Not Available

  • Kinston Medical Specialists

    Kinston, North Carolina 28501
    United States

    Site Not Available

  • Annie Penn Cancer Center

    Reidsville, North Carolina 27320
    United States

    Site Not Available

  • Bismarck Cancer Center

    Bismarck, North Dakota 58501
    United States

    Site Not Available

  • Medcenter One Hospital Cancer Care Center

    Bismarck, North Dakota 58501
    United States

    Site Not Available

  • Mid Dakota Clinic, PC

    Bismarck, North Dakota 58501
    United States

    Site Not Available

  • St. Alexius Medical Center Cancer Center

    Bismarck, North Dakota 58502
    United States

    Site Not Available

  • Altru Cancer Center at Altru Hospital

    Grand Forks, North Dakota 58201
    United States

    Site Not Available

  • Trinity CancerCare Center

    Minot, North Dakota 58701
    United States

    Site Not Available

  • McDowell Cancer Center at Akron General Medical Center

    Akron, Ohio 44307
    United States

    Site Not Available

  • Summa Center for Cancer Care at Akron City Hospital

    Akron, Ohio 44309-2090
    United States

    Site Not Available

  • Barberton Citizens Hospital

    Barberton, Ohio 44203
    United States

    Site Not Available

  • Mary Rutan Hospital

    Bellefontaine, Ohio 43311
    United States

    Site Not Available

  • Adena Regional Medical Center

    Chillicothe, Ohio 45601
    United States

    Site Not Available

  • CCOP - Columbus

    Columbus, Ohio 43215
    United States

    Site Not Available

  • Doctors Hospital at Ohio Health

    Columbus, Ohio 43228
    United States

    Site Not Available

  • Grant Medical Center Cancer Care

    Columbus, Ohio 43215
    United States

    Site Not Available

  • Mount Carmel Health - West Hospital

    Columbus, Ohio 43222
    United States

    Site Not Available

  • Riverside Methodist Hospital Cancer Care

    Columbus, Ohio 43214-3998
    United States

    Site Not Available

  • CCOP - Dayton

    Dayton, Ohio 45420
    United States

    Site Not Available

  • David L. Rike Cancer Center at Miami Valley Hospital

    Dayton, Ohio 45409
    United States

    Site Not Available

  • Good Samaritan Hospital

    Dayton, Ohio 45406
    United States

    Site Not Available

  • Grandview Hospital

    Dayton, Ohio 45405
    United States

    Site Not Available

  • Samaritan North Cancer Care Center

    Dayton, Ohio 45415
    United States

    Site Not Available

  • Grady Memorial Hospital

    Delaware, Ohio 43015
    United States

    Site Not Available

  • Blanchard Valley Medical Associates

    Findlay, Ohio 45840
    United States

    Site Not Available

  • Middletown Regional Hospital

    Franklin, Ohio 45005-1066
    United States

    Site Not Available

  • Wayne Hospital

    Greenville, Ohio 45331
    United States

    Site Not Available

  • Charles F. Kettering Memorial Hospital

    Kettering, Ohio 45429
    United States

    Site Not Available

  • Fairfield Medical Center

    Lancaster, Ohio 43130
    United States

    Site Not Available

  • St. Rita's Medical Center

    Lima, Ohio 45801
    United States

    Site Not Available

  • Strecker Cancer Center at Marietta Memorial Hospital

    Marietta, Ohio 45750
    United States

    Site Not Available

  • Knox Community Hospital

    Mount Vernon, Ohio 43050
    United States

    Site Not Available

  • Licking Memorial Cancer Care Program at Licking Memorial Hospital

    Newark, Ohio 43055
    United States

    Site Not Available

  • Community Hospital of Springfield and Clark County

    Springfield, Ohio 45505
    United States

    Site Not Available

  • UVMC Cancer Care Center at Upper Valley Medical Center

    Troy, Ohio 45373-1300
    United States

    Site Not Available

  • Mount Carmel St. Ann's Cancer Center

    Westerville, Ohio 43081
    United States

    Site Not Available

  • Clinton Memorial Hospital

    Wilmington, Ohio 45177
    United States

    Site Not Available

  • United States Air Force Medical Center - Wright-Patterson

    Wright-Patterson Afb, Ohio 45433-5529
    United States

    Site Not Available

  • Ruth G. McMillan Cancer Center at Greene Memorial Hospital

    Xenia, Ohio 45385
    United States

    Site Not Available

  • Genesis - Good Samaritan Hospital

    Zanesville, Ohio 43701
    United States

    Site Not Available

  • Natalie Warren Bryant Cancer Center at St. Francis Hospital

    Tulsa, Oklahoma 74136
    United States

    Site Not Available

  • Rosenfeld Cancer Center at Abington Memorial Hospital

    Abington, Pennsylvania 19001
    United States

    Site Not Available

  • Geisinger Cancer Institute at Geisinger Health

    Danville, Pennsylvania 17822-0001
    United States

    Site Not Available

  • Geisinger Hazleton Cancer Center

    Hazleton, Pennsylvania 18201
    United States

    Site Not Available

  • Joan Karnell Cancer Center at Pennsylvania Hospital

    Philadelphia, Pennsylvania 19107
    United States

    Site Not Available

  • Cancer Center at Phoenixville Hospital

    Phoenixville, Pennsylvania 19460
    United States

    Site Not Available

  • Guthrie Cancer Center at Guthrie Clinic Sayre

    Sayre, Pennsylvania 18840
    United States

    Site Not Available

  • Geisinger Medical Group - Scenery Park

    State College, Pennsylvania 16801
    United States

    Site Not Available

  • Chester County Hospital

    West Chester, Pennsylvania 19380
    United States

    Site Not Available

  • Frank M. and Dorothea Henry Cancer Center at Geisinger Wyoming Valley Medical Center

    Wilkes-Barre, Pennsylvania 18711
    United States

    Site Not Available

  • Roper St. Francis Cancer Center at Roper Hospital

    Charleston, South Carolina 29401
    United States

    Site Not Available

  • Cancer Centers of the Carolinas - Easley

    Easley, South Carolina 29640
    United States

    Site Not Available

  • McLeod Regional Medical Center

    Florence, South Carolina 29501
    United States

    Site Not Available

  • CCOP - Greenville

    Greenville, South Carolina 29615
    United States

    Site Not Available

  • Cancer Centers of the Carolinas - Faris Road

    Greenville, South Carolina 29605
    United States

    Site Not Available

  • Cancer Centers of the Carolinas - Grove Commons

    Greenville, South Carolina 29605
    United States

    Site Not Available

  • Greenville Hospital Cancer Center

    Greenville, South Carolina 29605
    United States

    Site Not Available

  • Self Regional Cancer Center at Self Regional Medical Center

    Greenwood, South Carolina 29646
    United States

    Site Not Available

  • Cancer Centers of the Carolinas - Greer Medical Oncology

    Greer, South Carolina 29650
    United States

    Site Not Available

  • Cancer Centers of the Carolinas - Seneca

    Seneca, South Carolina 29672
    United States

    Site Not Available

  • Cancer Centers of the Carolinas - Spartanburg

    Spartanburg, South Carolina 29307
    United States

    Site Not Available

  • Medical X-Ray Center, PC

    Sioux Falls, South Dakota 57105
    United States

    Site Not Available

  • Sanford Cancer Center at Sanford USD Medical Center

    Sioux Falls, South Dakota 57117-5039
    United States

    Site Not Available

  • Christine LaGuardia Phillips Cancer Center at Wellmont Holston Valley Medical Center

    Kingsport, Tennessee 37662
    United States

    Site Not Available

  • U.T. Medical Center Cancer Institute

    Knoxville, Tennessee 37920-6999
    United States

    Site Not Available

  • Hematology-Oncology Associates of Fredericksburg, Incorporated

    Fredericksburg, Virginia 22408
    United States

    Site Not Available

  • Southwest Virginia Regional Cancer Center at Wellmonth Health

    Norton, Virginia 24273
    United States

    Site Not Available

  • St. Joseph Cancer Center

    Bellingham, Washington 98225
    United States

    Site Not Available

  • Providence Centralia Hospital

    Centralia, Washington 98531-9027
    United States

    Site Not Available

  • St. Francis Hospital

    Federal Way, Washington 98003
    United States

    Site Not Available

  • Cascade Cancer Center at Evergreen Hospital Medical Center

    Kirkland, Washington 98033
    United States

    Site Not Available

  • Providence St. Peter Hospital Regional Cancer Center

    Olympia, Washington 98506-5166
    United States

    Site Not Available

  • Good Samaritan Cancer Center

    Puyallup, Washington 98372
    United States

    Site Not Available

  • CCOP - Virginia Mason Research Center

    Seattle, Washington 98101
    United States

    Site Not Available

  • Pacific Medical Center

    Seattle, Washington 98104
    United States

    Site Not Available

  • Virginia Mason Medical Center

    Seattle, Washington 98101
    United States

    Site Not Available

  • Allenmore Hospital

    Tacoma, Washington 98405
    United States

    Site Not Available

  • CCOP - Northwest

    Tacoma, Washington 98405
    United States

    Site Not Available

  • Franciscan Cancer Center at St. Joseph Medical Center

    Tacoma, Washington 98405-3004
    United States

    Site Not Available

  • MultiCare Regional Cancer Center at Tacoma General Hospital

    Tacoma, Washington 98405
    United States

    Site Not Available

  • St. Clare Hospital

    Tacoma, Washington 98499
    United States

    Site Not Available

  • North Star Lodge Cancer Center at Yakima Valley Memorial Hospital

    Yakima, Washington 98902
    United States

    Site Not Available

  • Edwards Comprehensive Cancer Center at Cabell Huntington Hospital

    Huntington, West Virginia 25701
    United States

    Site Not Available

  • Marshfield Clinic - Chippewa Center

    Chippewa Falls, Wisconsin 54729
    United States

    Site Not Available

  • Marshfield Clinic Cancer Care at Regional Cancer Center

    Eau Claire, Wisconsin 54701
    United States

    Site Not Available

  • Green Bay Oncology, Limited at St. Mary's Hospital

    Green Bay, Wisconsin 54303
    United States

    Site Not Available

  • Green Bay Oncology, Limited at St. Vincent Hospital Regional Cancer Center

    Green Bay, Wisconsin 54301-3526
    United States

    Site Not Available

  • St. Mary's Hospital Medical Center - Green Bay

    Green Bay, Wisconsin 54303
    United States

    Site Not Available

  • St. Vincent Hospital Regional Cancer Center

    Green Bay, Wisconsin 54307-3508
    United States

    Site Not Available

  • Gundersen Lutheran Center for Cancer and Blood

    La Crosse, Wisconsin 54601
    United States

    Site Not Available

  • Dean Medical Center - Madison

    Madison, Wisconsin 53717
    United States

    Site Not Available

  • Holy Family Memorial Medical Center Cancer Care Center

    Manitowoc, Wisconsin 54221-1450
    United States

    Site Not Available

  • Bay Area Cancer Care Center at Bay Area Medical Center

    Marinette, Wisconsin 54143
    United States

    Site Not Available

  • Marshfield Clinic - Marshfield Center

    Marshfield, Wisconsin 54449
    United States

    Site Not Available

  • Columbia Saint Mary's Hospital - Ozaukee

    Mequon, Wisconsin 53097
    United States

    Site Not Available

  • Columbia-Saint Mary's Cancer Care Center

    Milwaukee, Wisconsin 53211
    United States

    Site Not Available

  • Marshfield Clinic - Lakeland Center

    Minocqua, Wisconsin 54548
    United States

    Site Not Available

  • Green Bay Oncology, Limited - Oconto Falls

    Oconto Falls, Wisconsin 54154
    United States

    Site Not Available

  • Ministry Medical Group at Saint Mary's Hospital

    Rhinelander, Wisconsin 54501
    United States

    Site Not Available

  • Marshfield Clinic - Indianhead Center

    Rice Lake, Wisconsin 54868
    United States

    Site Not Available

  • St. Nicholas Hospital

    Sheboygan, Wisconsin 53081
    United States

    Site Not Available

  • Marshfield Clinic at Saint Michael's Hospital

    Stevens Point, Wisconsin 54481
    United States

    Site Not Available

  • Green Bay Oncology, Limited - Sturgeon Bay

    Sturgeon Bay, Wisconsin 54235
    United States

    Site Not Available

  • Marshfield Clinic - Weston Center

    Weston, Wisconsin 54476
    United States

    Site Not Available

  • Marshfield Clinic - Wisconsin Rapids Center

    Wisconsin Rapids, Wisconsin 54494
    United States

    Site Not Available

  • Welch Cancer Center at Sheridan Memorial Hospital

    Sheridan, Wyoming 82801
    United States

    Site Not Available

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