Neomycin and Rifaximin Plus Neomycin in Treating Methane Positive Constipation Predominant Irritable Bowel Syndrome

Inclusion Criteria:

• Rome III positive IBS subjects (18-75 years of age)

• Meet criteria for constipation predominant IBS symptoms including ≤ 3 completespontaneous bowel movements per week with hard or lumpy stools.

• Presence of detectable methane on single breath sample (≥ 3ppm).

• If subjects are ≥ 50 years old, a colonoscopy had to have been completed within thepast 5 years.

Exclusion Criteria:

• Subjects with history of intestinal surgery (except appendectomy or cholecystectomy)

• Recent antibiotic use (within the last 30 days)

• Subjects with known pelvic floor dysfunction

• Pregnancy

• Creatinine level > 1.4

• Poorly controlled/uncontrolled significant medical condition that would interfere withstudy procedures

• Subjects with hearing loss and/or tinnitus

• History of bowel obstruction

• History of celiac disease

• History of inflammatory bowel disease

• Cirrhosis

• Diabetes