Endothelial Function in Patients With Sickle Cell Anemia Before and After Sildenafil

Last updated: February 28, 2010
Sponsor: The Baruch Padeh Medical Center, Poriya
Overall Status: Trial Not Available

Phase

4

Condition

Sickle Cell Disease

Anemia

Bone Marrow Disorder

Treatment

N/A

Clinical Study ID

NCT00937144
SCA123-CTIL
  • Ages 18-60
  • All Genders

Study Summary

The investigators would like to study the endothelial function in sickle cell patients without pulmonary hypertension in an in vivo method during a steady state condition before and after sildenafil treatment for 1 month, and to study the effects of this nitric oxide donor by measuring the Flow Mediated Dilatation, by measuring endothelial progenitor stem cells colonies, and by measuring the effect of therapy on markers of inflammation (cell adhesion molecules and cytokines).

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • patients with sickle cell anemia

Exclusion

Exclusion Criteria:

  • patients with sickle cell anemia during acute crisis

Study Design

Total Participants: 15
Study Start date:
September 01, 2009
Estimated Completion Date:
February 28, 2010

Connect with a study center

  • Baruch Padeh Poria Medical Center

    Tiberias, Lower Galilee 15208
    Israel

    Site Not Available

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