Comparison of Two Heparin Formulations in Patients With Chronic Renal Failure.

Inclusion Criteria:

1. Research that patients agreed to participate and signed the written informed consent;

2. Patients aged over 18 years, both sexes, regardless of color or social class;

3. Patients with impaired renal function in chronic hemodialysis schedule of at least 3times a week and giving the use of heparin in the prophylaxis of thrombosis in thesystem.

Exclusion Criteria:

1. Hypersensitivity to heparin sodium and / or benzyl alcohol;

2. History of bleeding or disease that the change of blood coagulation could aggravate orterminate the clinical manifestations, such as tables of active peptic or gastriculcer;

3. Severe liver disease;

4. Cancer;

5. Period of gestation;

6. Genetic abnormality of the coagulation system;

7. Multiple trauma;

8. Use of aspirin in high doses (above 200mg per day);

9. Use of glucocorticoids for at least 1 month;

10. Use of other anticoagulants;

11. Submission of a big surgery done less than 15 days;

12. History of persistent hypertension at the end of dialysis than 150/100 mmHg;

13. Indicated doses of heparin 20% above or below 150UI/kg.