Introduction and Influence of Total Mesorectal Excision (TME) in the Treatment of Rectal Cancer

Last updated: May 28, 2009
Sponsor: University Hospital Inselspital, Berne
Overall Status: Completed

Phase

N/A

Condition

Colorectal Cancer

Digestive System Neoplasms

Rectal Cancer

Treatment

N/A

Clinical Study ID

NCT00910143
KEK 08-05-09
  • Ages > 16
  • All Genders

Study Summary

Total mesorectal excision (TME) is a rather new operation technique in the treatment of rectal cancer. It is known to reduce the rate of local recurrences. However, the influence on long-term survival is unclear.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • adenocarcinoma of the rectum

  • 16 years and older

Study Design

Total Participants: 194
Study Start date:
January 01, 1993
Estimated Completion Date:
December 31, 2001

Study Description

Background

The TME technique for rectal cancer surgery was introduced in our department in summer 1995. TME is known to reduce the rate of local recurrences. However, its influence on long-term survival in unclear.

All patients with rectal cancer from 1993 to 2001 are reviewed. The patients charts are reviewed and the following main characteristics are retrieved: age, gender, time of operation, operation technique, tumor stage, tumor localisation, tumor size, neoadjuvant or adjuvant treatment, complications, follow-up with respect to the appearance of local recurrences and distant metastases.

Comparison of two groups of patients. Group 1: patients operated before summer 1995, that is before the introduction of TME. Group 2: patients operated after summer 1995, that is after the introduction of TME.

Objective

Study the influence of a new operation method (TME) on outcome (local recurrence, survival).

Methods

All patients with rectal cancer from 1993 to 2001 are reviewed. The patients charts are reviewed and the following main characteristics are retrieved: age, gender, time of operation, operation technique, tumor stage, tumor localisation, tumor size, neoadjuvant or adjuvant treatment, complications, follow-up with respect to the appearance of local recurrences and distant metastases.

Comparison of two groups of patients. Group 1: patients operated before summer 1995, that is before the introduction of TME. Group 2: patients operated after summer 1995, that is after the introduction of TME.

Connect with a study center

  • Dep. of visceral and transplant surgery, Bern University Hospital

    Bern, 3010
    Switzerland

    Site Not Available

Map preview placeholder

Not the study for you?

Let us help you find the best match. Sign up as a volunteer and receive email notifications when clinical trials are posted in the medical category of interest to you.