Importance of Aldosterone in the Pathogenesis of Hypertensive Heart Disease

Last updated: July 6, 2012
Sponsor: University of Erlangen-Nürnberg Medical School
Overall Status: Completed

Phase

3

Condition

High Blood Pressure (Hypertension - Pediatric)

Vascular Diseases

High Blood Pressure (Hypertension)

Treatment

N/A

Clinical Study ID

NCT00865501
KFO-TP5-I
  • Ages 18-40
  • Male

Study Summary

The Renin-Angiotensin-Aldosterone-system is important in the development of cardiovascular organ damage caused by arterial hypertension. This study aims at evaluating the importance of aldosterone with regard to hypertension induced damage to the heart. In order to do this the investigators will perform a comparative cross-sectional study in hypertensives and normotensives. In addition as interventional part the hypertensives will be treated with a mineralocorticoid-receptor blocker (spironolactone).

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Clinical diagnosis hypertension (BP higher than 139/89)

Exclusion

Exclusion Criteria:

  • Antihypertensive pretreatment

  • Contraindications against spironolactone

  • Being unable to understand or comply with study procedures

Study Design

Total Participants: 50
Study Start date:
March 01, 2008
Estimated Completion Date:
December 31, 2009

Connect with a study center

  • University Erlangen-Nürnberg, Nephrology and Hypertension

    Erlangen, 91054
    Germany

    Site Not Available

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