Role of Angiogenesis in Dermatologic Diseases: A Potential Therapeutic Target

Last updated: April 2, 2025
Sponsor: University of California, Irvine
Overall Status: Active - Recruiting

Phase

N/A

Condition

Skin Conditions

Treatment

skin tissue sample

Clinical Study ID

NCT00842283
20076094
  • Ages > 16
  • All Genders
  • Accepts Healthy Volunteers

Study Summary

The researchers believe that pro-angiogenic factors are upregulated in a wide range of dermatologic diseases, including port wine stains, hemangiomas, angiofibromas, Kaposi's sarcoma, angiosarcoma, scars, rosacea, and psoriasis. Select specimens may undergo genetic analysis to investigate underlying molecular pathways associated with dysregulated angiogenesis in cutaneous disease.

Biospecimens, either previously obtained or newly collected from dermatologic conditions, will be analyzed for angiogenic markers. Discarded skin tissue from surgical or biopsy procedures may also be used, including both diseased and non-diseased tissue from the same donor. Some specimens may also undergo genetic analysis to investigate underlying molecular pathways.

De-identified data such as age, sex, race, cause of death, lesion location, and description will be recorded. Currently, specimens are limited to clinically diagnosed lesions not typically biopsied, or lesions already confirmed by prior biopsy.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • 16 years of age or older.

  • willing to have a skin biopsy

Exclusion

Exclusion Criteria:

  • under 16 years of age

  • unable to carry out instructions

Study Design

Total Participants: 85
Treatment Group(s): 1
Primary Treatment: skin tissue sample
Phase:
Study Start date:
November 01, 2008
Estimated Completion Date:
December 31, 2026

Study Description

Biospecimens from various dermatologic diseases, including port wine stains, hemangiomas, angiofibromas, Kaposi's sarcoma, angiosarcoma, scars, rosacea, and psoriasis will be evaluated for markers of angiogenesis. Additionally, researchers can use discarded human skin tissue samples from skin biopsy/surgery sites, which are removed for closure but are not submitted for histopathologic analysis. We may use donated tissue with both dermatologic disease and non-diseased tissue from the same donor. Biopsies may also be taken for molecular and genetic analysis of specimen. Non-identifiable information regarding the patient, such as age, sex, race, cause of death, location, and description of diseased skin may be recorded.

Connect with a study center

  • Beckman Laser Institute Medical clinic

    Irvine, California 92612
    United States

    Site Not Available

  • Beckman Laser Institute and Medical Clinic

    Irvine, California 92697
    United States

    Active - Recruiting

  • Dermatology Clinic at Gavin Herbert Eye Institute

    Irvine, California 92697
    United States

    Active - Recruiting

  • Gottschalk Medical Plaza

    Irvine, California 92612
    United States

    Active - Recruiting

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