A Comparison of Antiplatelet Therapies in Asian Subjects With Acute Coronary Syndrome

Inclusion Criteria:

• A person who has been diagnosed with acute coronary syndrome (ACS) and is to undergo apercutaneous coronary intervention (PCI)

• A person who is of East or Southeast Asian descent

• A person who is of the legal age of 18 (or age 21 in Singapore) and is mentallycompetent to provide a signed written informed consent before entering the study

• If a woman is of childbearing potential, she must test negative for pregnancy andagree to use a reliable method of birth control

Exclusion Criteria:

• A person who has a severe cardiovascular condition such as cardiogenic shock at thetime of randomization, ventricular arrhythmias or congestive heart failure

• A person who is at an increased risk of bleeding (e.g. active internal bleeding,history of bleeding disorder, recent fibrinolytic therapy before randomization intothe study)

• A person who has prior history of any one of the following: ischemic or hemorrhagicstroke; intracranial neoplasm, arteriovenous malformation, or aneurysm; prior historyof transient ischemic attack (TIA)

• A person who needs to take other antiplatelet therapy other than Aspirin for theduration of the study

• A person who receives daily treatment with nonsteroidal anti-inflammatory drugs (NSAIDs) or cyclooxygenase-2 (COX2) inhibitors that cannot be discontinued

• A person who has a severe liver disease, such as cirrhosis

• A person who has a condition such as alcoholism, mental illness, or drug dependence