Study of Cilostazol and Probucol to Assess Their Effects on Atherosclerosis Related Biomarker

Inclusion Criteria:

• 40~75-year-old male or female

• Clarified diagnosis of type 2 diabetes mellitus

• Arteriosclerosis obliterans (ASO) is diagnosed (ASO diagnoses should meet at leastone of the conditions as below:

• ABI<1.0;

• The pulse of popliteal artery or dorsalis pedis artery is weeken significantlyor is different between left and right sides

• Intermittent claudication, diagnosed as ASO by doctor

• Ultrasonogram showed that there was atherosclerotic plaque in lower limb within 1 year

• Informed Consent Form Signature

Exclusion Criteria:

• Has an allergic history to study drugs

• Use one of the following drugs: other antiplatelet or anticoagulation agents exceptAspirin, other hypolipidemic agents except Statins

• Type 1 diabetes mellitus, specific diabetes mellitus, or gestational diabetesmellitus

• Has severe ASO above Fontaine IIb,

• Hemorrhagic tendency or hemorrhagic disease (such as gastrointestinal tracthemorrhage, etc.)

• Had a myocardial infarction, angina pectoris, or cerebral infarction within the last 3 months

• Congestive heart failure

• Is pregnant, or potentially pregnant, or breastfeeding

• Severe hepatic insufficient or severe renal insufficiency (AST or ALT is 2.5 timeshigher than the upper limit of the normal value range, or serum creatinine is 1.2times higher than the upper limit of the normal value range)

• Persistent or hardly controlled hypertension (such as malignant hypertension, BP> 160/100 mmHg)

• Severe ventricular arrhythmia (such as multiple and multifocal premature ventricularcontractions)

• Has a medical history that includes a cardiac syncope or a primary syncope

• Has conditions that may prolong QT interval (such as congenital long QT syndrome,taking drugs which prolong QT interval, hypokalemia or hypomagnesemia, etc.)

• Has severe complications (such as diabetes mellitus ketoacidosis, nonketotichyperosmolar diabetic coma, malignant tumor, severe anaemia, severe hematologicdiseases, etc.)

• Other conditions that would exclude the subject from this study by doctor'sjudgement