Associations Between Depression and Cardiovascular Disease - a Study of Patients With Late Onset Depression

Last updated: November 20, 2012
Sponsor: University of Aarhus
Overall Status: Completed

Phase

N/A

Condition

Coronary Artery Disease

Chest Pain

Depression (Major/severe)

Treatment

N/A

Clinical Study ID

NCT00818506
CPF-TAD-1
  • Ages 50-70
  • All Genders
  • Accepts Healthy Volunteers

Study Summary

Studies show that depression is a risk factor for the development of coronary artery disease (CAD). Furthermore there is an increased occurrence of depression in patients with CAD. Among other mechanisms atherosclerosis is believed to play a central role regarding these notable associations between depression and CAD. Moreover, patients with late onset major depression have an increased number of small lesions found in the white matter of the brain, the so-called white matter lesions. The main goal of this project is to examine if CAD is associated with depression and/or white matter lesions. CAD is evaluated using coronary CT angiography. Depression is evaluated using a semi-structured diagnostic interview. White matter lesions are quantified using cerebral magnetic resonance.

Eligibility Criteria

Inclusion

INCLUSION CRITERIA:

  • Submitted to psychiatric hospital, district psychiatry or private psychiatrist becauseof major depressive disorder.

  • Meets the criteria for Major Depressive Disorder, Single Episode as defined in theDiagnostic and Statistical Manual, fourth edition (DSM-IV) and the InternationalClassification of Diseases (ICD-10).

  • Age 50-70 years.

  • Written informed consent.

  • Caucasian.

Exclusion

EXCLUSION CRITERIA:

  • Known, or anamnestic/objective signs of, organic brain disease.

  • Organic, including symptomatic, mental disorders as (ICD-10: F00-F09).

  • Dependence syndrome within the last 5 years (ICD-10: F1x.2) or current harmful use (ICD-10: F1x.1) of alcohol or other psychoactive substances.

  • Schizophrenia, schizotypal and delusional disorders (ICD-10: F20-F29).

  • Subject to force of law according to the danish law on psychiatry.

  • Present risk of suicide.

  • Previous cranial trauma resulting in unconsciousness for more than 2 minutes.

  • Medical history of renal failure.

  • Other conditions which contraindicate specific procedures in the project.

  • Other conditions deemed to prevent the subject from completing the examinationprogram.

  • Does not want to participate.

Study Design

Total Participants: 55
Study Start date:
March 01, 2009
Estimated Completion Date:
June 30, 2012

Connect with a study center

  • Center of Psychiatric Research, Aarhus University Hospital

    Aarhus, 8200
    Denmark

    Site Not Available

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