Efficacy of Distilled Water Versus Mitomycin C on Preventing Recurrences of Bladder Cancer After Transurethral Resection

Last updated: February 16, 2009
Sponsor: Bozyaka Training and Research Hospital
Overall Status: Trial Status Unknown

Phase

2/3

Condition

Bladder Cancer

Urothelial Cancer

Treatment

N/A

Clinical Study ID

NCT00816075
URO-DW-1971
  • All Genders

Study Summary

The purpose of this study is to compare and evaluate the efficacy of distilled water vs Mitomycin C on preventing the recurrences of intermediate risk group recurrent superficial bladder cancer administered as a single dose immediate instillation after complete Transurethral Resection(TUR) of the tumor.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • pathologic finding of superficial bladder cancer within the intermediate risk group

  • recurred after 6 months from the primary tumor

  • those patients who were included in our follow-up program since 2002 and whose recordscould be obtained.

Exclusion

Exclusion Criteria:

  • carcinoma in situ

  • any form of intracavitary maintenance therapy

  • any form of bladder cancer other than transitional cell type

Study Design

Total Participants: 40
Study Start date:
February 01, 2009
Estimated Completion Date:
April 30, 2011

Study Description

We plan to administer 200ml of distilled water as a single peroperative instillation and block the catheter for 2 hours to our eligible recurrent superficial bladder cancer patients who were in our follow-up schedule since 2002.

We plan to look over the histories of the same patients in terms of the pathologies, recurrence patterns, the presence of peroperative intracavitary therapy after their previous TURs for recurrences.

So we shall compare the effectiveness of MMC and distilled water on reducing the recurrences over the same patient pool.

The patients will be scheduled for a follow-up program after TUR as;

  • cystoscopy

  • urine cytology

  • bladder wash cytology for the probability of recurrence for 2 years to see if there is any difference in the recurrence patterns after instillation with distilled water vs MMC.

Connect with a study center

  • Bozyaka Training and Research Hospital Urology Clinic

    Izmir,
    Turkey

    Site Not Available

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