Intraoperative Celiac Plexus Neurolysis for Patients With Operable Pancreatic and Periampullary Cancer

Last updated: May 14, 2025
Sponsor: Sidney Kimmel Cancer Center at Thomas Jefferson University
Overall Status: Completed

Phase

3

Condition

Pancreatic Disorders

Pancreatitis

Pancreatic Cancer

Treatment

Alcohol Block

Clinical Study ID

NCT00806611
08D.380
2007-32
JT 1239
  • Ages > 18
  • All Genders

Study Summary

Determine if the addition of an intraoperative ethanol celiac plexus neurolysis (alcohol block) in patients undergoing surgical intervention for pancreatic cancer will result in a decrease in cancer associated pain

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Preoperative imaging indicates possibility of resectable pancreatic cancer

  • Intraoperative biopsy histologically confirming pancreatic adenocarcinoma

Exclusion

Exclusion Criteria:

Study Design

Total Participants: 438
Treatment Group(s): 1
Primary Treatment: Alcohol Block
Phase: 3
Study Start date:
September 01, 2008
Estimated Completion Date:
April 30, 2013

Study Description

Pancreatic adenocarcinoma is the fourth leading cause of cancer related death in the United States and is usually fatal. Surgery provides the only chance for long-term survival. Pain is a significant, often difficult to control component of survivorship for many who succumb to this disease. The purpose of this trial is to evaluate the effect of ethanol celiac plexus neurolysis (alcohol nerve block) in patients undergoing surgical intervention for pancreatic cancer. Patients undergoing surgery for pancreatic cancer will be enrolled in a prospective randomized double blind placebo controlled clinical trial.

This protocol is designed to definitively determine the role of ethanol celiac plexus neurolysis as a simple addition to the surgical management of pancreatic adenocarcinoma and help define the standard of care for cancer associated pain management in this disease.

Connect with a study center

  • Thomas Jefferson University

    Philadelphia, Pennsylvania 19107
    United States

    Site Not Available

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