Magnetic Resonance Imaging of Aortic Aneurysm Instability

Last updated: June 17, 2021
Sponsor: University of Edinburgh
Overall Status: Completed

Phase

2/3

Condition

Cardiovascular Disease

Heart Disease

Aneurysm

Treatment

N/A

Clinical Study ID

NCT00794092
2007/R/CAR/15
  • Ages > 40
  • All Genders

Study Summary

Abdominal aortic aneurysm (AAA) is a progressive enlargement of the aorta, the largest blood vessel in the body. It is at risk of bursting when it is usually fatal. Currently the risk of the AAA bursting is estimated from its diameter. In this study, the investigators hope to develop a new type of aneurysm scan involving Magnetic Resonance Imaging (MRI). It is hoped that this scan will be better at determining which AAAs are at risk of bursting and therefore require an operation to prevent this.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • AAA measuring >40mm in AP diameter on ultrasound scanning
  • Age >40 years (patients younger than this with AAA may have a connective tissuedisorder and a different aetiology to their disease)
  • Considered to be suitable for standard infra-renal open surgical repair

Exclusion

Exclusion Criteria:

  • Patients who are not deemed to be fit for open surgical repair
  • Patients who are deemed to be suitable for a stent graft performed by the radiologistsrather than the standard operation
  • Contraindication to MRI scanning identified from MRI Safety Questionnaire (seeattached)or claustrophobia
  • Age <40 years
  • Patients requiring emergent repair such that there is insufficient time available tocomplete the protocol
  • Patients refusing to give consent
  • Patients unable to give consent
  • Pregnant women (contrast is teratogenic in animals)
  • Intercurrent illness (may confound the results)
  • Patients with a systemic inflammatory disorder or underlying malignancy
  • Patients who require an emergency operation such that there is insufficient time tocomplete the study protocol
  • Renal dysfunction (Creat >250 or eGFR<25)
  • Hepatic dysfunction (Child's grade B or C)

Study Design

Total Participants: 29
Study Start date:
November 01, 2008
Estimated Completion Date:
June 30, 2010

Study Description

Abdominal aortic aneurysms (AAA) have a prevalence of ~5% and when ruptured carry a mortality rate of ~90%. The pathophysiology of AAA encompasses a range of poorly understood biomechanical and biological processes. Currently the diameter of the aneurysm is used as a surrogate for the risk of rupture and patients with an aneurysm diameter greater than 55 mm are considered for elective surgical repair. However, this reliance on a single surrogate measure is too simplistic and does not take into account other physical and biological aspects of the AAA. We propose to evaluate the role of inflammation, proteolysis and neovascularisation in patients with AAA disease. We will compare novel magnetic resonance imaging techniques with blood and tissue measures of inflammation (c-reactive protein, cytokines, macrophage and leucocyte density), proteolytic activity (matrix metalloproteinases, tissue inhibitors of metalloproteinases) and neovascularisation (vessel density, endothelial progenitor cells). By comparing findings between patients with symptomatic and asymptomatic disease, this study will inform our understanding of the disease process as well as potentially identify risk markers of AAA instability that could be used to follow-up patients with asymptomatic disease.

Connect with a study center

  • University of Edinburgh/Royal Infirmary of Edinburgh

    Edinburgh, Midlothian Eh16 4SA
    United Kingdom

    Site Not Available

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