S0715: Acetyl-L-Carnitine in Preventing Neuropathy in Women With Stage I, II, or IIIA Breast Cancer Undergoing Chemo

Last updated: June 29, 2017
Sponsor: Southwest Oncology Group
Overall Status: Completed

Phase

3

Condition

Neurologic Disorders

Neuropathy

Cancer

Treatment

N/A

Clinical Study ID

NCT00775645
CDR0000617081
U10CA037429
S0715
  • Ages 18-120
  • Female

Study Summary

RATIONALE: Acetyl-L-carnitine may prevent or lessen neuropathy caused by chemotherapy. It is not yet known whether acetyl-L-carnitine is more effective than a placebo in preventing neuropathy caused by chemotherapy.

PURPOSE: This randomized phase III trial is studying acetyl-L-carnitine to see how well it works compared with a placebo in preventing neuropathy in women with stage I, stage II, or stage III breast cancer undergoing chemotherapy.

Eligibility Criteria

Inclusion

DISEASE CHARACTERISTICS:

  • Histologically confirmed primary invasive adenocarcinoma of the breast

  • Stage I-III disease

  • No metastatic disease

  • Must have undergone modified radical mastectomy or breast-sparing surgery

  • Planning to receive one of the following standard taxane-based systemic chemotherapy regimens as adjuvant therapy for breast cancer:

  • Paclitaxel 80 mg/m² weekly for 12 weeks

  • Paclitaxel 175 mg/m² every other week for 4 courses (8 weeks)

  • Paclitaxel 175 mg/m² every other week for 6 courses (12 weeks)

  • Docetaxel 75 mg/m² every 3 weeks for 4 courses (12 weeks)

  • Docetaxel 75 mg/m² every 3 weeks for 6 courses (18 weeks)

  • No history of neuropathy

  • Hormone receptor status not specified

PATIENT CHARACTERISTICS:

  • Menopausal status not specified

  • Zubrod performance status 0-2

  • Serum creatinine ≤ 2.5 times upper limit of normal

  • Not pregnant or nursing

  • Fertile patients must use effective contraception

  • Able to complete questionnaires in English or Spanish

  • Willing to submit blood samples for DNA extraction, genotyping analysis, and nerve growth factor studies

  • No history of diabetes

  • No history of seizure disorder

  • No other malignancy within the past 5 years except adequately treated basal cell or squamous cell skin cancer, carcinoma in situ of the cervix, ductal carcinoma in situ, or adequately treated stage I or stage II malignancy from which the patient is currently in complete remission

PRIOR CONCURRENT THERAPY:

  • See Disease Characteristics

  • Recovered from prior breast surgery

  • Prior neoadjuvant or adjuvant chemotherapy allowed

  • No prior taxane therapy

  • No prior biologic therapy for treatment of breast cancer

  • No concurrent vitamin E, glutamine, gabapentin, nortriptyline, amitriptyline, or duloxetine hydrochloride

  • Multivitamins containing vitamin E allowed provided vitamin E dose is < 1,000 IU

  • No concurrent anti-seizure medications

  • Concurrent hormonal therapy allowed

  • Concurrent biologic therapy allowed (e.g., Herceptin)

  • Concurrent participation in another therapeutic clinical trial allowed

Study Design

Total Participants: 437
Study Start date:
September 01, 2009
Estimated Completion Date:
June 30, 2013

Study Description

OBJECTIVES:

Primary

  • Compare whether treatment with acetyl-L-carnitine hydrochloride vs placebo prevents symptoms of neuropathy as measured by the 11-item neurotoxicity component of the FACT-Taxane Questionnaire at 12 weeks after study registration in women with stage I, II, or IIIA breast cancer undergoing adjuvant taxane-based chemotherapy.

Secondary

  • Compare the functional status of these patients using the Trial Outcome Index from the Functional Assessment of Cancer Therapy (FACT)-Taxane Questionnaire.

  • Compare fatigue in these patients using the Function Assessment of Chronic Illness Therapy (FACIT)-Fatigue Symptom Module.

Other

  • Compare the proportion of patients experiencing grade 3 or 4 neuropathy.

  • Compare serum nerve growth factor levels in these patients.

  • Describe the total dose of taxane received and treatment delays, compliance with therapy, and use of concurrent medications, dietary supplements (e.g., glutamine), vitamin E, and complementary and alternative medicines in these patients.

  • Explore the relationship between nerve growth factor levels and the degree of neuropathy and functional status in these patients.

  • Explore the relationship between genetic markers responsible for taxane metabolism and clearance (e.g., CYP2C8, CYP3A4, CYP3A5, GSTM1, and GSTP1) and the degree of neuropathy in these patients.

OUTLINE: This is a multicenter study. Patients are stratified according to planned adjuvant chemotherapy regimen for breast cancer (paclitaxel weekly for 12 weeks vs paclitaxel biweekly for 4 courses [8 weeks] vs paclitaxel biweekly for 6 courses [12 weeks] vs docetaxel every 3 weeks for 4 courses [12 weeks] vs docetaxel every 3 weeks for 6 courses [18 weeks]) and age (< 60 years vs ≥ 60 years). Patients are randomized to 1 of 2 treatment arms.

  • Arm I: Patients receive oral acetyl-L-carnitine hydrochloride 3 times daily for 24 weeks.

  • Arm II: Patients receive oral placebo 3 times daily for 24 weeks. Patients complete the FACT-Taxane Trial Outcome Index and the FACIT-Fatigue Symptom Module questionnaires at baseline, at 12, 24, and 36 weeks, and at 1 and 2 years.

Blood samples are collected at baseline and at week 12 for biomarker analysis (nerve growth factor levels) by ELISA, DNA extraction, and genotyping analysis.

Connect with a study center

  • Providence Cancer Center at Providence Hospital

    Mobile, Alabama 36608
    United States

    Site Not Available

  • Alaska Regional Hospital Cancer Center

    Anchorage, Alaska 99508
    United States

    Site Not Available

  • Providence Cancer Center

    Anchorage, Alaska 99508
    United States

    Site Not Available

  • Fairbanks Cancer Treatment Center at Fairbanks Memorial Hospital

    Fairbanks, Alaska 99701
    United States

    Site Not Available

  • Kaiser Permanente - Deer Valley

    Antioch, California 94531
    United States

    Site Not Available

  • Alta Bates Summit Comprehensive Cancer Center

    Berkeley, California 94704
    United States

    Site Not Available

  • Peninsula Medical Center

    Burlingame, California 94010
    United States

    Site Not Available

  • East Bay Radiation Oncology Center

    Castro Valley, California 94546
    United States

    Site Not Available

  • Eden Medical Center

    Castro Valley, California 94546
    United States

    Site Not Available

  • Valley Medical Oncology Consultants - Castro Valley

    Castro Valley, California 94546
    United States

    Site Not Available

  • Kaiser Permanente - Fremont

    Fremont, California 94538
    United States

    Site Not Available

  • Valley Medical Oncology

    Fremont, California 94538
    United States

    Site Not Available

  • Glendale Memorial Hospital Comprehensive Cancer Center

    Glendale, California 91204
    United States

    Site Not Available

  • Kaiser Permanente Medical Center - Hayward

    Hayward, California 94545
    United States

    Site Not Available

  • USC/Norris Comprehensive Cancer Center and Hospital

    Los Angeles, California 90089-9181
    United States

    Site Not Available

  • Contra Costa Regional Medical Center

    Martinez, California 94553-3156
    United States

    Site Not Available

  • Tibotec Therapeutics - Division of Ortho Biotech Products, LP

    Marysville, California 95901
    United States

    Site Not Available

  • El Camino Hospital Cancer Center

    Mountain View, California 94040
    United States

    Site Not Available

  • Alta Bates Summit Medical Center - Summit Campus

    Oakland, California 94609
    United States

    Site Not Available

  • Bay Area Breast Surgeons, Incorporated

    Oakland, California 94609
    United States

    Site Not Available

  • CCOP - Bay Area Tumor Institute

    Oakland, California 94609
    United States

    Site Not Available

  • Highland General Hospital

    Oakland, California 94602
    United States

    Site Not Available

  • Kaiser Permanente Medical Center - Oakland

    Oakland, California 94611
    United States

    Site Not Available

  • Larry G Strieff MD Medical Corporation

    Oakland, California 94609
    United States

    Site Not Available

  • Tom K Lee, Incorporated

    Oakland, California 94609
    United States

    Site Not Available

  • Valley Care Medical Center

    Pleasanton, California 94588
    United States

    Site Not Available

  • Valley Medical Oncology Consultants - Pleasanton

    Pleasanton, California 94588
    United States

    Site Not Available

  • Kaiser Permanente Medical Center - Redwood City

    Redwood City, California 94063
    United States

    Site Not Available

  • Kaiser Permanente Medical Center - Richmond

    Richmond, California 94801
    United States

    Site Not Available

  • Kaiser Permanente Medical Center - Roseville

    Roseville, California 95661
    United States

    Site Not Available

  • Sutter Cancer Center at Roseville Medical Center

    Roseville, California 95661
    United States

    Site Not Available

  • Kaiser Permanente Medical Center - Sacramento

    Sacramento, California 95825
    United States

    Site Not Available

  • South Sacramento Kaiser-Permanente Medical Center

    Sacramento, California 95823
    United States

    Site Not Available

  • Sutter Cancer Center

    Sacramento, California 95816
    United States

    Site Not Available

  • University of California Davis Cancer Center

    Sacramento, California 95817
    United States

    Site Not Available

  • California Pacific Medical Center - California Campus

    San Francisco, California 94118
    United States

    Site Not Available

  • Kaiser Permanente Medical Center - San Francisco Geary Campus

    San Francisco, California 94115
    United States

    Site Not Available

  • Kaiser Permanente Medical Center - Santa Teresa

    San Jose, California 95119
    United States

    Site Not Available

  • Doctors Medical Center - San Pablo Campus

    San Pablo, California 94806
    United States

    Site Not Available

  • Kaiser Foundation Hospital - San Rafael

    San Rafael, California 94903
    United States

    Site Not Available

  • Sutter Health - Western Division Cancer Research Group

    San Rafael, California 94903
    United States

    Site Not Available

  • Kaiser Permanente Medical Center - Santa Clara Kiely Campus

    Santa Clara, California 95051
    United States

    Site Not Available

  • Kaiser Permanente Medical Center - Santa Rosa

    Santa Rosa, California 95403
    United States

    Site Not Available

  • Kaiser Permanente Medical Center - South San Francisco

    South San Francisco, California 94080
    United States

    Site Not Available

  • Kaiser Permanente Medical Facility - Stockton

    Stockton, California 95210
    United States

    Site Not Available

  • Tahoe Forest Cancer Center

    Truckee, California 96161
    United States

    Site Not Available

  • Kaiser Permanente Medical Center - Vacaville

    Vacaville, California 95688
    United States

    Site Not Available

  • Kaiser Permanente Medical Center - Vallejo

    Vallejo, California 94589
    United States

    Site Not Available

  • Sutter Solano Medical Center

    Vallejo, California 94589
    United States

    Site Not Available

  • Kaiser Permanente Medical Center - Walnut Creek

    Walnut Creek, California 94596
    United States

    Site Not Available

  • San Luis Valley Regional Medical Center

    Alamosa, Colorado 81101
    United States

    Site Not Available

  • University of Colorado Cancer Center at UC Health Sciences Center

    Aurora, Colorado 80045
    United States

    Site Not Available

  • Denver Health Medical Center

    Denver, Colorado 80204
    United States

    Site Not Available

  • Kaiser Permanente - Denver

    Denver, Colorado 80205
    United States

    Site Not Available

  • Shaw Regional Cancer Center

    Edwards, Colorado 81632
    United States

    Site Not Available

  • Poudre Valley Hospital

    Fort Collins, Colorado 80524
    United States

    Site Not Available

  • Valley View Hospital Cancer Center

    Glenwood Springs, Colorado 81601
    United States

    Site Not Available

  • St. Mary's Regional Cancer Center at St. Mary's Hospital and Medical Center

    Grand Junction, Colorado 81502
    United States

    Site Not Available

  • Kaiser Permanente - Lafayette

    Lafayette, Colorado 80026
    United States

    Site Not Available

  • Montrose Memorial Hospital Cancer Center

    Montrose, Colorado 81401
    United States

    Site Not Available

  • Saint Francis/Mount Sinai Regional Cancer Center at Saint Francis Hospital and Medical Center

    Hartford, Connecticut 06105
    United States

    Site Not Available

  • CCOP - Atlanta Regional

    Atlanta, Georgia 30342
    United States

    Site Not Available

  • Northside Hospital Cancer Center

    Atlanta, Georgia 30342-1611
    United States

    Site Not Available

  • Piedmont Hospital

    Atlanta, Georgia 30309
    United States

    Site Not Available

  • Saint Joseph's Hospital of Atlanta

    Atlanta, Georgia 30342-1701
    United States

    Site Not Available

  • WellStar Cobb Hospital

    Austell, Georgia 30106
    United States

    Site Not Available

  • John B. Amos Cancer Center

    Columbus, Georgia 31904
    United States

    Site Not Available

  • Charles B. Eberhart Cancer Center at DeKalb Medical Center

    Decatur, Georgia 30033
    United States

    Site Not Available

  • Northeast Georgia Medical Center

    Gainesville, Georgia 30501
    United States

    Site Not Available

  • Gwinnett Medical Center

    Lawrenceville, Georgia 30045
    United States

    Site Not Available

  • Kennestone Cancer Center at Wellstar Kennestone Hospital

    Marietta, Georgia 30060
    United States

    Site Not Available

  • Southern Regional Medical Center

    Riverdale, Georgia 30274-2600
    United States

    Site Not Available

  • Harbin Clinic Cancer Center - Medical Oncology

    Rome, Georgia 30165
    United States

    Site Not Available

  • Nancy N. and J. C. Lewis Cancer and Research Pavilion at St. Joseph's/Candler

    Savannah, Georgia 31405
    United States

    Site Not Available

  • Pearlman Comprehensive Cancer Center at South Georgia Medical Center

    Valdosta, Georgia 31603
    United States

    Site Not Available

  • Kapiolani Medical Center at Pali Momi

    'Aiea, Hawaii 96701
    United States

    Site Not Available

  • Kapiolani Medical Center at Pali Momi

    Aiea, Hawaii 96701
    United States

    Site Not Available

  • Cancer Research Center of Hawaii

    Honolulu, Hawaii 96813
    United States

    Site Not Available

  • Hawaii Medical Center - East

    Honolulu, Hawaii 96817
    United States

    Site Not Available

  • Kaiser Permanente - Moanalua Medical Center and Clinic

    Honolulu, Hawaii 96819
    United States

    Site Not Available

  • Kapiolani Medical Center for Women and Children

    Honolulu, Hawaii 96826
    United States

    Site Not Available

  • OnCare Hawaii, Incorporated - Kuakini

    Honolulu, Hawaii 96817
    United States

    Site Not Available

  • OnCare Hawaii, Incorporated - Lusitana

    Honolulu, Hawaii 96813
    United States

    Site Not Available

  • Queen's Cancer Institute at Queen's Medical Center

    Honolulu, Hawaii 96813
    United States

    Site Not Available

  • Straub Clinic and Hospital, Incorporated

    Honolulu, Hawaii 96813
    United States

    Site Not Available

  • Tripler Army Medical Center

    Honolulu, Hawaii 96859
    United States

    Site Not Available

  • Pacific Cancer Institute - Maui

    Wailuku, Hawaii 96793
    United States

    Site Not Available

  • Saint Anthony's Hospital at Saint Anthony's Health Center

    Alton, Illinois 62002
    United States

    Site Not Available

  • Cancer Care Center of Decatur

    Decatur, Illinois 62526
    United States

    Site Not Available

  • Decatur Memorial Hospital Cancer Care Institute

    Decatur, Illinois 62526
    United States

    Site Not Available

  • Crossroads Cancer Center

    Effingham, Illinois 62401
    United States

    Site Not Available

  • Cardinal Bernardin Cancer Center at Loyola University Medical Center

    Maywood, Illinois 60153
    United States

    Site Not Available

  • Good Samaritan Regional Health Center

    Mount Vernon, Illinois 62864
    United States

    Site Not Available

  • Edward Hospital Cancer Center

    Naperville, Illinois 60540
    United States

    Site Not Available

  • Regional Cancer Center at Memorial Medical Center

    Springfield, Illinois 62781-0001
    United States

    Site Not Available

  • St. Francis Hospital and Health Centers - Beech Grove Campus

    Beech Grove, Indiana 46107
    United States

    Site Not Available

  • Reid Hospital & Health Care Services

    Richmond, Indiana 47374
    United States

    Site Not Available

  • Genesis Medical Center - West Campus

    Davenport, Iowa 52804
    United States

    Site Not Available

  • Genesis Regional Cancer Center at Genesis Medical Center

    Davenport, Iowa 52803
    United States

    Site Not Available

  • Cancer Center of Kansas, PA - Chanute

    Chanute, Kansas 66720
    United States

    Site Not Available

  • Cancer Center of Kansas, PA - Dodge City

    Dodge City, Kansas 67801
    United States

    Site Not Available

  • Cancer Center of Kansas, PA - El Dorado

    El Dorado, Kansas 67042
    United States

    Site Not Available

  • Cancer Center of Kansas - Fort Scott

    Fort Scott, Kansas 66701
    United States

    Site Not Available

  • Cancer Center of Kansas-Independence

    Independence, Kansas 67301
    United States

    Site Not Available

  • Cancer Center of Kansas, PA - Kingman

    Kingman, Kansas 67068
    United States

    Site Not Available

  • Lawrence Memorial Hospital

    Lawrence, Kansas 66044
    United States

    Site Not Available

  • Cancer Center of Kansas, PA - Liberal

    Liberal, Kansas 67905
    United States

    Site Not Available

  • Cancer Center of Kansas, PA - Newton

    Newton, Kansas 67114
    United States

    Site Not Available

  • Cancer Center of Kansas, PA - Parsons

    Parsons, Kansas 67357
    United States

    Site Not Available

  • Cancer Center of Kansas, PA - Pratt

    Pratt, Kansas 67124
    United States

    Site Not Available

  • Cancer Center of Kansas, PA - Salina

    Salina, Kansas 67401
    United States

    Site Not Available

  • Cotton-O'Neil Cancer Center

    Topeka, Kansas 66606
    United States

    Site Not Available

  • Cancer Center of Kansas, PA - Wellington

    Wellington, Kansas 67152
    United States

    Site Not Available

  • CCOP - Wichita

    Wichita, Kansas 67214
    United States

    Site Not Available

  • Cancer Center of Kansas, PA - Medical Arts Tower

    Wichita, Kansas 67208
    United States

    Site Not Available

  • Cancer Center of Kansas, PA - Wichita

    Wichita, Kansas 67214
    United States

    Site Not Available

  • Via Christi Cancer Center at Via Christi Regional Medical Center

    Wichita, Kansas 67214
    United States

    Site Not Available

  • Cancer Center of Kansas, PA - Winfield

    Winfield, Kansas 67156
    United States

    Site Not Available

  • Cancer Care at Our Lady of Bellefonte Hospital

    Ashland, Kentucky 41101
    United States

    Site Not Available

  • Northeast Louisiana Cancer Institute at St. Francis Medical Center

    Alexandria, Louisiana 71301
    United States

    Site Not Available

  • Tulane Cancer Center Office of Clinical Research

    Alexandria, Louisiana 71315-3198
    United States

    Site Not Available

  • Mary Bird Perkins Cancer Center - Baton Rouge

    Baton Rouge, Louisiana 70809
    United States

    Site Not Available

  • Louisiana State University Health Sciences Center - Monroe

    Monroe, Louisiana 71210
    United States

    Site Not Available

  • MBCCOP - LSU Health Sciences Center

    New Orleans, Louisiana 70112
    United States

    Site Not Available

  • Medical Center of Louisiana - New Orleans

    New Orleans, Louisiana 70112
    United States

    Site Not Available

  • Feist-Weiller Cancer Center at Louisiana State University Health Sciences

    Shreveport, Louisiana 71130-3932
    United States

    Site Not Available

  • Alvin and Lois Lapidus Cancer Institute at Sinai Hospital

    Baltimore, Maryland 21215
    United States

    Site Not Available

  • Boston University Cancer Research Center

    Boston, Massachusetts 02118
    United States

    Site Not Available

  • Caritas St. Elizabeth's Medical Center

    Brighton, Massachusetts 02135-2997
    United States

    Site Not Available

  • CCOP - Michigan Cancer Research Consortium

    Ann Arbor, Michigan 48106
    United States

    Site Not Available

  • Saint Joseph Mercy Cancer Center

    Ann Arbor, Michigan 48106-0995
    United States

    Site Not Available

  • Battle Creek Health System Cancer Care Center

    Battle Creek, Michigan 49017
    United States

    Site Not Available

  • Bay Regional Medical Center

    Bay City, Michigan 48708
    United States

    Site Not Available

  • Mecosta County Medical Center

    Big Rapids, Michigan 49307
    United States

    Site Not Available

  • Oakwood Cancer Center at Oakwood Hospital and Medical Center

    Dearborn, Michigan 48123-2500
    United States

    Site Not Available

  • Josephine Ford Cancer Center at Henry Ford Hospital

    Detroit, Michigan 48202
    United States

    Site Not Available

  • Genesys Hurley Cancer Institute

    Flint, Michigan 48503
    United States

    Site Not Available

  • Great Lakes Cancer Institute at McLaren Regional Medical Center

    Flint, Michigan 48532
    United States

    Site Not Available

  • Hurley Medical Center

    Flint, Michigan 48503
    United States

    Site Not Available

  • Butterworth Hospital at Spectrum Health

    Grand Rapids, Michigan 49503
    United States

    Site Not Available

  • CCOP - Grand Rapids

    Grand Rapids, Michigan 49503
    United States

    Site Not Available

  • Lacks Cancer Center at Saint Mary's Health Care

    Grand Rapids, Michigan 49503
    United States

    Site Not Available

  • Van Elslander Cancer Center at St. John Hospital and Medical Center

    Grosse Pointe Woods, Michigan 48236
    United States

    Site Not Available

  • Foote Memorial Hospital

    Jackson, Michigan 49201
    United States

    Site Not Available

  • Breslin Cancer Center at Ingham Regional Medical Center

    Lansing, Michigan 48910
    United States

    Site Not Available

  • Sparrow Regional Cancer Center

    Lansing, Michigan 48912-1811
    United States

    Site Not Available

  • Lapeer Regional Hospital

    Lapeer, Michigan 48446
    United States

    Site Not Available

  • St. Mary Mercy Hospital

    Livonia, Michigan 48154
    United States

    Site Not Available

  • MidMichigan Medical Center - Midland

    Midland, Michigan 48670
    United States

    Site Not Available

  • Mercy General Health Partners

    Muskegon, Michigan 49443
    United States

    Site Not Available

  • St. Joseph Mercy Oakland

    Pontiac, Michigan 48341-2985
    United States

    Site Not Available

  • Mercy Regional Cancer Center at Mercy Hospital

    Port Huron, Michigan 48060
    United States

    Site Not Available

  • William Beaumont Hospital - Royal Oak Campus

    Royal Oak, Michigan 48073
    United States

    Site Not Available

  • Seton Cancer Institute at Saint Mary's - Saginaw

    Saginaw, Michigan 48601
    United States

    Site Not Available

  • Providence Cancer Institute at Providence Hospital - Southfield Campus

    Southfield, Michigan 48075
    United States

    Site Not Available

  • Munson Medical Center

    Traverse City, Michigan 49684
    United States

    Site Not Available

  • St. John Macomb Hospital

    Warren, Michigan 48093
    United States

    Site Not Available

  • Metro Health Hospital

    Wyoming, Michigan 49519
    United States

    Site Not Available

  • University of Mississippi Cancer Clinic

    Jackson, Mississippi 39216
    United States

    Site Not Available

  • Regional Cancer Center at Singing River Hospital

    Pascagoula, Mississippi 39581
    United States

    Site Not Available

  • Skaggs Cancer Center at Skaggs Regional Medical Center

    Branson, Missouri 65616
    United States

    Site Not Available

  • Saint Francis Medical Center

    Cape Girardeau, Missouri 63703
    United States

    Site Not Available

  • CCOP - St. Louis-Cape Girardeau

    Saint Louis, Missouri 63141
    United States

    Site Not Available

  • David C. Pratt Cancer Center at St. John's Mercy

    Saint Louis, Missouri 63141
    United States

    Site Not Available

  • Midwest Hematology Oncology Group, Incorporated

    Saint Louis, Missouri 63109
    United States

    Site Not Available

  • CCOP - Cancer Research for the Ozarks

    Springfield, Missouri 65802
    United States

    Site Not Available

  • Hulston Cancer Center at Cox Medical Center South

    Springfield, Missouri 65807
    United States

    Site Not Available

  • St. John's Regional Health Center

    Springfield, Missouri 65804
    United States

    Site Not Available

  • Billings Clinic - Downtown

    Billings, Montana 59107-7000
    United States

    Site Not Available

  • CCOP - Montana Cancer Consortium

    Billings, Montana 59101
    United States

    Site Not Available

  • Hematology-Oncology Centers of the Northern Rockies - Billings

    Billings, Montana 59102
    United States

    Site Not Available

  • Northern Rockies Radiation Oncology Center

    Billings, Montana 59101
    United States

    Site Not Available

  • St. Vincent Healthcare Cancer Care Services

    Billings, Montana 59101
    United States

    Site Not Available

  • Bozeman Deaconess Cancer Center

    Bozeman, Montana 59715
    United States

    Site Not Available

  • St. James Healthcare Cancer Care

    Butte, Montana 59701
    United States

    Site Not Available

  • Big Sky Oncology

    Great Falls, Montana 59405-5309
    United States

    Site Not Available

  • Great Falls Clinic - Main Facility

    Great Falls, Montana 59405
    United States

    Site Not Available

  • Sletten Cancer Institute at Benefis Healthcare

    Great Falls, Montana 59405
    United States

    Site Not Available

  • Great Falls, Montana 59405
    United States

    Site Not Available

  • Northern Montana Hospital

    Havre, Montana 59501
    United States

    Site Not Available

  • St. Peter's Hospital

    Helena, Montana 59601
    United States

    Site Not Available

  • Glacier Oncology, PLLC

    Kalispell, Montana 59901
    United States

    Site Not Available

  • Kalispell Medical Oncology at KRMC

    Kalispell, Montana 59901
    United States

    Site Not Available

  • Guardian Oncology and Center for Wellness

    Missoula, Montana 59804
    United States

    Site Not Available

  • Montana Cancer Center at St. Patrick Hospital and Health Sciences Center

    Missoula, Montana 59807
    United States

    Site Not Available

  • Montana Cancer Specialists at Montana Cancer Center

    Missoula, Montana 59807-7877
    United States

    Site Not Available

  • CCOP - Nevada Cancer Research Foundation

    Las Vegas, Nevada 89106
    United States

    Site Not Available

  • University Medical Center of Southern Nevada

    Las Vegas, Nevada 89102
    United States

    Site Not Available

  • Lovelace Medical Center - Downtown

    Albuquerque, New Mexico 87102
    United States

    Site Not Available

  • Presbyterian Cancer Treatment Center at Presbyterian Kaseman Hospital

    Albuquerque, New Mexico 87110
    United States

    Site Not Available

  • University of New Mexico Cancer Center

    Albuquerque, New Mexico 87131-5636
    United States

    Site Not Available

  • University of New Mexico Cancer Center - South

    Las Cruces, New Mexico 88011
    United States

    Site Not Available

  • Tucker Center for Cancer Care at Orange Regional Medical Center

    Middletown, New York 10940-4199
    United States

    Site Not Available

  • Herbert Irving Comprehensive Cancer Center at Columbia University Medical Center

    New York, New York 10032
    United States

    Site Not Available

  • CaroMont Cancer Center at Gaston Memorial Hospital

    Gastonia, North Carolina 28053
    United States

    Site Not Available

  • Wayne Memorial Hospital, Incorporated

    Goldsboro, North Carolina 27534
    United States

    Site Not Available

  • Pardee Memorial Hospital

    Hendersonville, North Carolina 28791
    United States

    Site Not Available

  • High Point Regional Hospital

    High Point, North Carolina 27261
    United States

    Site Not Available

  • Rutherford Hospital

    Rutherfordton, North Carolina 28139
    United States

    Site Not Available

  • Iredell Memorial Hospital

    Statesville, North Carolina 28677
    United States

    Site Not Available

  • McDowell Cancer Center at Akron General Medical Center

    Akron, Ohio 44307
    United States

    Site Not Available

  • Cleveland Clinic Beachwood Family Health and Surgery Center

    Beachwood, Ohio 44122
    United States

    Site Not Available

  • Mary Rutan Hospital

    Bellefontaine, Ohio 43311
    United States

    Site Not Available

  • Adena Regional Medical Center

    Chillicothe, Ohio 45601
    United States

    Site Not Available

  • Charles M. Barrett Cancer Center at University Hospital

    Cincinnati, Ohio 45267
    United States

    Site Not Available

  • Cleveland Clinic Cancer Center at Fairview Hospital

    Cleveland, Ohio 44111
    United States

    Site Not Available

  • Cleveland Clinic Taussig Cancer Center

    Cleveland, Ohio 44195
    United States

    Site Not Available

  • CCOP - Columbus

    Columbus, Ohio 43215
    United States

    Site Not Available

  • Doctors Hospital at Ohio Health

    Columbus, Ohio 43228
    United States

    Site Not Available

  • Grant Medical Center Cancer Care

    Columbus, Ohio 43215
    United States

    Site Not Available

  • Mount Carmel Health - West Hospital

    Columbus, Ohio 43222
    United States

    Site Not Available

  • Riverside Methodist Hospital Cancer Care

    Columbus, Ohio 43214-3998
    United States

    Site Not Available

  • CCOP - Dayton

    Dayton, Ohio 45420
    United States

    Site Not Available

  • David L. Rike Cancer Center at Miami Valley Hospital

    Dayton, Ohio 45409
    United States

    Site Not Available

  • Good Samaritan Hospital

    Dayton, Ohio 45406
    United States

    Site Not Available

  • Grandview Hospital

    Dayton, Ohio 45405
    United States

    Site Not Available

  • Samaritan North Cancer Care Center

    Dayton, Ohio 45415
    United States

    Site Not Available

  • Grady Memorial Hospital

    Delaware, Ohio 43015
    United States

    Site Not Available

  • Blanchard Valley Medical Associates

    Findlay, Ohio 45840
    United States

    Site Not Available

  • Middletown Regional Hospital

    Franklin, Ohio 45005-1066
    United States

    Site Not Available

  • Wayne Hospital

    Greenville, Ohio 45331
    United States

    Site Not Available

  • Cleveland Clinic Cancer Center

    Independence, Ohio 44131
    United States

    Site Not Available

  • Charles F. Kettering Memorial Hospital

    Kettering, Ohio 45429
    United States

    Site Not Available

  • Fairfield Medical Center

    Lancaster, Ohio 43130
    United States

    Site Not Available

  • MedCentral - Mansfield Hospital

    Mansfield, Ohio 44903
    United States

    Site Not Available

  • Strecker Cancer Center at Marietta Memorial Hospital

    Marietta, Ohio 45750
    United States

    Site Not Available

  • Hillcrest Cancer Center at Hillcrest Hospital

    Mayfield Heights, Ohio 44124
    United States

    Site Not Available

  • Knox Community Hospital

    Mount Vernon, Ohio 43050
    United States

    Site Not Available

  • Licking Memorial Cancer Care Program at Licking Memorial Hospital

    Newark, Ohio 43055
    United States

    Site Not Available

  • Community Hospital of Springfield and Clark County

    Springfield, Ohio 45505
    United States

    Site Not Available

  • UVMC Cancer Care Center at Upper Valley Medical Center

    Troy, Ohio 45373-1300
    United States

    Site Not Available

  • Mount Carmel St. Ann's Cancer Center

    Westerville, Ohio 43081
    United States

    Site Not Available

  • Clinton Memorial Hospital

    Wilmington, Ohio 45177
    United States

    Site Not Available

  • Cleveland Clinic - Wooster

    Wooster, Ohio 44691
    United States

    Site Not Available

  • United States Air Force Medical Center - Wright-Patterson

    Wright-Patterson Afb, Ohio 45433-5529
    United States

    Site Not Available

  • United States Air Force Medical Center - Wright-Patterson

    Wright-Patterson Air Force Base, Ohio 45433-5529
    United States

    Site Not Available

  • Ruth G. McMillan Cancer Center at Greene Memorial Hospital

    Xenia, Ohio 45385
    United States

    Site Not Available

  • Genesis - Good Samaritan Hospital

    Zanesville, Ohio 43701
    United States

    Site Not Available

  • St. Charles Medical Center - Bend

    Bend, Oregon 97701
    United States

    Site Not Available

  • Bay Area Hospital

    Coos Bay, Oregon 97420
    United States

    Site Not Available

  • Legacy Mount Hood Medical Center

    Gresham, Oregon 97030
    United States

    Site Not Available

  • Providence Milwaukie Hospital

    Milwaukie, Oregon 97222
    United States

    Site Not Available

  • Adventist Medical Center

    Portland, Oregon 97216
    United States

    Site Not Available

  • CCOP - Columbia River Oncology Program

    Portland, Oregon 97225
    United States

    Site Not Available

  • Kaiser Permanente Health Care - Portland

    Portland, Oregon 97227
    United States

    Site Not Available

  • Legacy Emanuel Hospital and Health Center and Children's Hospital

    Portland, Oregon 97227
    United States

    Site Not Available

  • Legacy Good Samaritan Hospital & Comprehensive Cancer Center

    Portland, Oregon 97210
    United States

    Site Not Available

  • Northwest Cancer Specialists at Rose Quarter Cancer Center

    Portland, Oregon 97227
    United States

    Site Not Available

  • Providence Cancer Center at Providence Portland Medical Center

    Portland, Oregon 97213-2967
    United States

    Site Not Available

  • Providence St. Vincent Medical Center

    Portland, Oregon 97225
    United States

    Site Not Available

  • Salem Hospital Regional Cancer Care Services

    Salem, Oregon 97309-5014
    United States

    Site Not Available

  • Legacy Meridian Park Hospital

    Tualatin, Oregon 97062
    United States

    Site Not Available

  • AnMed Cancer Center

    Anderson, South Carolina 29621
    United States

    Site Not Available

  • Cancer Centers of the Carolinas - Easley

    Easley, South Carolina 29640
    United States

    Site Not Available

  • Bon Secours St. Francis Health System

    Greenville, South Carolina 29601
    United States

    Site Not Available

  • CCOP - Greenville

    Greenville, South Carolina 29615
    United States

    Site Not Available

  • Cancer Centers of the Carolinas - Faris Road

    Greenville, South Carolina 29605
    United States

    Site Not Available

  • Cancer Centers of the Carolinas - Grove Commons

    Greenville, South Carolina 29605
    United States

    Site Not Available

  • Greenville Hospital Cancer Center

    Greenville, South Carolina 29605
    United States

    Site Not Available

  • Self Regional Cancer Center at Self Regional Medical Center

    Greenwood, South Carolina 29646
    United States

    Site Not Available

  • Cancer Centers of the Carolinas - Greer Medical Oncology

    Greer, South Carolina 29650
    United States

    Site Not Available

  • Cancer Centers of the Carolinas - Seneca

    Seneca, South Carolina 29672
    United States

    Site Not Available

  • CCOP - Upstate Carolina

    Spartanburg, South Carolina 29303
    United States

    Site Not Available

  • Cancer Centers of the Carolinas - Spartanburg

    Spartanburg, South Carolina 29307
    United States

    Site Not Available

  • Gibbs Regional Cancer Center at Spartanburg Regional Medical Center

    Spartanburg, South Carolina 29303
    United States

    Site Not Available

  • St. Joseph Cancer Center

    Bellingham, Washington 98225
    United States

    Site Not Available

  • Olympic Hematology and Oncology

    Bremerton, Washington 98310
    United States

    Site Not Available

  • Providence Centralia Hospital

    Centralia, Washington 98531-9027
    United States

    Site Not Available

  • St. Francis Hospital

    Federal Way, Washington 98003
    United States

    Site Not Available

  • Columbia Basin Hematology

    Kennewick, Washington 99336
    United States

    Site Not Available

  • Cascade Cancer Center at Evergreen Hospital Medical Center

    Kirkland, Washington 98033
    United States

    Site Not Available

  • Skagit Valley Hospital Cancer Care Center

    Mount Vernon, Washington 98273
    United States

    Site Not Available

  • Skagit Valley Hospital Cancer Care Center

    Mt. Vernon, Washington 98273
    United States

    Site Not Available

  • Providence St. Peter Hospital Regional Cancer Center

    Olympia, Washington 98506-5166
    United States

    Site Not Available

  • Harrison Poulsbo Hematology and Onocology

    Poulsbo, Washington 98370
    United States

    Site Not Available

  • Good Samaritan Cancer Center

    Puyallup, Washington 98372
    United States

    Site Not Available

  • CCOP - Virginia Mason Research Center

    Seattle, Washington 98101
    United States

    Site Not Available

  • Fred Hutchinson Cancer Research Center

    Seattle, Washington 98109
    United States

    Site Not Available

  • Group Health Central Hospital

    Seattle, Washington 98112
    United States

    Site Not Available

  • Harborview Medical Center

    Seattle, Washington 98104
    United States

    Site Not Available

  • Minor and James Medical, PLLC

    Seattle, Washington 98104
    United States

    Site Not Available

  • Pacific Medical Center

    Seattle, Washington 98104
    United States

    Site Not Available

  • Polyclinic First Hill

    Seattle, Washington 98122
    United States

    Site Not Available

  • Swedish Cancer Institute at Swedish Medical Center - First Hill Campus

    Seattle, Washington 98122-4307
    United States

    Site Not Available

  • University Cancer Center at University of Washington Medical Center

    Seattle, Washington 98195
    United States

    Site Not Available

  • Cancer Care Northwest - Spokane South

    Spokane, Washington 99202
    United States

    Site Not Available

  • Evergreen Hematology and Oncology, PS

    Spokane, Washington 99218
    United States

    Site Not Available

  • Allenmore Hospital

    Tacoma, Washington 98405
    United States

    Site Not Available

  • CCOP - Northwest

    Tacoma, Washington 98405
    United States

    Site Not Available

  • Franciscan Cancer Center at St. Joseph Medical Center

    Tacoma, Washington 98405-3004
    United States

    Site Not Available

  • MultiCare Regional Cancer Center at Tacoma General Hospital

    Tacoma, Washington 98405
    United States

    Site Not Available

  • St. Clare Hospital

    Tacoma, Washington 98499
    United States

    Site Not Available

  • Legacy Salmon Creek Medical Center

    Vancouver, Washington 98686
    United States

    Site Not Available

  • Southwest Washington Medical Center Cancer Center

    Vancouver, Washington 98668
    United States

    Site Not Available

  • Wenatchee Valley Medical Center

    Wenatchee, Washington 98801-2028
    United States

    Site Not Available

  • North Star Lodge Cancer Center at Yakima Valley Memorial Hospital

    Yakima, Washington 98902
    United States

    Site Not Available

  • Rocky Mountain Oncology

    Casper, Wyoming 82609
    United States

    Site Not Available

  • Welch Cancer Center at Sheridan Memorial Hospital

    Sheridan, Wyoming 82801
    United States

    Site Not Available

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