BIIB023 (Anti-TWEAK) in Subjects With Rheumatoid Arthritis

Inclusion Criteria:

• Diagnosis of adult onset RA (functional class I-III) for at least 6 months

• Must have been treated with and be tolerating Methotrexate (5-25 mg/week) for 3months, at a stable dose for at least 4 weeks

• Must have at least 4 swollen and tender joints due to rheumatoid arthritis

Exclusion Criteria:

• History of recurrent infections requiring antibiotic treatment within 12 months

• Serious local infection or systemic infection within 3 months

• Suffering from rheumatic or autoimmune disease other than RA

• History of cancer, heart failure, kidney disease, liver disease, HIV infection,tuberculosis or other serious illness