Strain-Encoded Cardiac Magnetic Resonance Imaging for Dobutamine Stress Testing

Phase

N/A

Condition

Hypercholesterolemia

Thrombosis

Myocardial Ischemia

Treatment

N/A

Clinical Study ID

NCT00758654

MRI-021

Ages > 18
All Genders
Accepts Healthy Volunteers

Study Summary

The purpose of this study is to compare the diagnostic value of SENC to that provided by conventional wall motion analysis for the detection of inducible ischemia during DS-MRI.High-dose dobutamine stress magnetic resonance imaging (DS-MRI) is safe and feasible for the diagnosis of coronary artery disease (CAD) in humans. However, the assessment of cine scans relies on the visual interpretation of regional wall motion, which is subjective. Recently, Strain-Encoded MRI (SENC) has been proposed for the direct color-coded visualization of myocardial strain.

Eligibility Criteria

Inclusion

Inclusion Criteria:

Suspected or known coronary artery disease

Exclusion

Exclusion Criteria:

General contraindication for a dobutamine stress or for an MRI examination
Age < 18 yrs

Study Design

January 01, 2007

January 31, 2011

Study Description

The assessment of inducible regional wall motion abnormalities during high-dose dobutamine stress magnetic resonance imaging (DS-MRI) is an established clinical method with high diagnostic and prognostic value for the evaluation of patients with coronary artery disease (CAD). However, the assessment of cine images relies on the visual interpretation of regional wall motion, which is subjective, and objective approaches for the detection of inducible ischemia with DS-MRI are still lacking.

In our study Strain-Encoded-MRI (SENC) is used for the objective color-coded evaluation of regional myocardial strain during DS-MRI in patients with intermediate to high pretest probability for CAD. We anticipated that this technique would exhibit enhanced sensitivity for the detection of anatomically significant CAD compared to conventional wall motion reading, with invasive coronary angiography used as the standard reference.

Connect with a study center

University of Heidelberg, Department of Cardiology
Heidelberg, 69120
Germany
Site Not Available

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