Effect of Different Dosing Regimens of Clopidogrel Before Elective Percutaneous Coronary Intervention (PCI) on Platelet Function

Last updated: August 20, 2012
Sponsor: Hopital du Sacre-Coeur de Montreal
Overall Status: Completed

Phase

3

Condition

Vascular Diseases

Chest Pain

Cardiovascular Disease

Treatment

N/A

Clinical Study ID

NCT00693069
C.E.2004-06-24A
  • Ages 18-90
  • All Genders

Study Summary

Adequate platelet inhibition before percutaneous coronary intervention (PCI) reduces peri-procedural and long-term ischemic complications. Documented reduced response to clopidogrel has been associated with subsequent major adverse cardiovascular events. Strategies to optimize platelet inhibition pre-PCI are under investigation.

This study sought to evaluate the effect on platelet aggregation of four different dosing regimens of clopidogrel given before elective PCI.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Adult patient with an indication for elective coronary angiography with or without PCI

Exclusion

Exclusion Criteria:

  • major hemorrhagic diathesis or active bleeding

  • acute myocardial infarction (MI) within 14 days of enrolment

  • unstable angina with ST-segment changes >1 mm in at least two contiguouselectrocardiographic leads at rest or a troponin I level >0.06 microg/L within 14 daysof enrolment

  • stroke within the past 3 months

  • platelet count <100 x 10 9/L

  • prothrombin time > 1.5 times control

  • hematocrit <25% or hemoglobin level <100 g/L

  • alcohol or drug abuse

  • enrolment in other investigational drug trials within the previous month

  • use of thienopyridines, glycoprotein (GP) IIb/IIIa inhibitors, warfarin oracenocoumarol within the previous week

  • allergic reaction or any contraindication to clopidogrel or aspirin administration

Study Design

Total Participants: 120
Study Start date:
September 01, 2004
Estimated Completion Date:
April 30, 2006

Connect with a study center

  • Hopital du Sacre-Coeur de Montreal

    Montreal, Quebec H4J 1C5
    Canada

    Site Not Available

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