Effect of Exercise and Phytoestrogen on Bone, Metabolic Syndrome Criteria and Complaints of the Early Menopause

Last updated: May 27, 2015
Sponsor: University of Erlangen-Nürnberg Medical School
Overall Status: Terminated

Phase

3

Condition

Coronary Artery Disease

Hypercholesterolemia

Atherosclerosis

Treatment

N/A

Clinical Study ID

NCT00663104
OFZ-Trace
  • Ages 45-55
  • Female
  • Accepts Healthy Volunteers

Study Summary

The aim of the study is to compare the effect of a progressive, periodized exercise training designed to impact bone, CHD-risk-factors and menopausal complaints versus the combined effect of exercise and "phytoestrogen" (cimicifuga racemosa; CR). After randomization, 84 females 1-3 year postmenopausal with no medication or illness affecting bone metabolism exercise over 12 months (EG; 42 with, 42 without CR), 42 women serve as wellness-control. Three group training sessions/week will be performed in the EG. Both groups will be individually supplemented with calcium and Vit-D (cholecalciferol).

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • 1-3 years early postmenopausal

  • Caucasian race

Exclusion

Exclusion Criteria:

  • CHD-diseases

  • thrombosis, embolism

  • fractures at lumbar spine or hip

  • secondary osteoporosis

  • hyperparathyroidism

  • medication, diseases with impact on muscle or bone

  • cancer and hormone derived malign diseases

  • weight reduction of > 5 kg during the last 6 months

Study Design

Total Participants: 126
Study Start date:
April 01, 2008
Estimated Completion Date:
November 30, 2009

Connect with a study center

  • Institute of Medical Physics

    Erlangen, 91052
    Germany

    Site Not Available

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