Factorial Study of Metoprolol Succinate TOPROL-XL (324A)

Last updated: March 24, 2009
Sponsor: AstraZeneca
Overall Status: Completed

Phase

3

Condition

Circulation Disorders

Williams Syndrome

Vascular Diseases

Treatment

N/A

Clinical Study ID

NCT00642096
D4026C00001
  • Ages 18-80
  • All Genders

Study Summary

The purpose of this research study is to determine if treatment with the combination of metoprolol succinate and hydrochlorothiazide is more effective at lowering blood pressure than treatment with either of the two drugs alone. The study will also determine which combined doses of metoprolol succinate and hydrochlorothiazide are most effective at lowering blood pressure (without unacceptable side effects), and whether it is possible to combine both drugs in a single tablet to simplify blood pressure treatment.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Diastolic blood pressure between 95 and 114 mm at screening and start of treatment

Exclusion

Exclusion Criteria:

  • Significant conditions which in the opinion of the investigator place the subject atundue risk, eg Renal impairment, hepatitis

  • Known secondary causes of hypertension, eg, Cushing's syndrome, renal artery stenosis,pheochromocytoma, hyperaldosteronism

  • Systolic blood pressure greater or equal to 180 mm Hg at start of trial

Study Design

Total Participants: 1900
Study Start date:
June 01, 2003
Estimated Completion Date:
July 31, 2004