Phase
Condition
Sunspot Fungus (Tinea Versicolor)
Yeast Infections
Sexually Transmitted Diseases (Stds)
Treatment
N/AClinical Study ID
Study Summary
Eligibility Criteria
Inclusion
Inclusion Criteria:
Participant has a confirmed diagnosis of esophageal candidiasis or invasivecandidiasis for whom IV antifungal therapy is appropriate
FOR ESOPHAGEAL CANDIDIASIS
Participant has endoscopic evidence of esophageal candidiasis
Participant has disease documented by symptoms consistent with esophageal candidiasisand positive stain or wetmount KOH of brushing or biopsy from endoscopy followed bypositive culture for Candida or positive histopathologic evidence of Candida infection
FOR INVASIVE CANDIDIASIS
Participant has at least 1 positive culture of a Candida species from blood or othernormally sterile body site obtained within 96 hours of study entry
Participant has clinical evidence of infection within 96 hours before study entry
Temperature >100^◦F (37.8^◦F) on 2 occasions at least 4 hours apart or 1 determinationof >101^◦F (38.3^◦F) or clinically significant hypothermia <96.8^◦F (36.0^◦C)
Systolic blood pressure <90 or ≥30 mm Hg decrease in systolic blood pressure from theparticipant's normal baseline
Signs of inflammation at a site infected with Candida
Exclusion
Exclusion Criteria:
Participant has any of the following abnormal laboratory values: InternationalNormalization Ratio (INR) >1.6 or, if participant is receiving anticoagulants, INR >4.0; bilirubin >5 times the upper limit of normal range; aspartate aminotransferase (AST, or serum glutamic oxaloacetic transaminase [SGOT]) oralanine aminotransferase (ALT, or serum glutamic pyruvic transaminase [SGPT]) >5 times theupper limit of normal range
FOR ESOPHAGEAL CANDIDIASIS
Participant has Candida disease limited to the oropharynx
Participant has another cause of esophagitis or has clearly defined ulcers onendoscopy with high likelihood of another non-Candida pathogen
Participant has other esophageal pathology on endoscopy that is unrelated to acuteesophageal candidiasis
FOR INVASIVE CANDIDIASIS
Participant has evidence of infection limited to a positive culture for Candida fromurine, sputum, catheter tip, indwelling drain, or mucosal or superficial skin surface
Participant has suspected Candida endocarditis, osteomyelitis, or meningitis