CRESTOR Athero Imaging Head to Head IVUS Study

Inclusion Criteria:

• Clinical indication for coronary angiography

• Angiographic evidence of Coronary Artery Disease (CAD), as defined by at least 1lesion in a native coronary artery that has >20% reduction in lumen diameter by visualestimation

• Left main coronary artery must have <=50% reduction in lumen diameter by visualestimation

• LDL-C >100 mg/dL (2.6 mmol/L) for patients with no statin therapy in the past 4 weeks;LDL-C >80mg/dL (2.08mmol/L) for patients on therapy in the past 4 weeks

Exclusion Criteria:

• Use of certain lipid-lowering medication for more than 3 months within the previous 12months. Longer periods of treatment are not permitted because of the potential effectsof such therapy on coronary atherosclerosis.

• Patients who have symptoms consistent with moderate or greater severity of CongestiveHeart Failure (CHF).

• Clinically significant heart disease which, in the opinion of the PrincipalInvestigator (or designee), is likely to require coronary bypass surgery, cardiactransplantation, surgical repair and/or replacement during the course of the study