A Study Combining FOLFOX or FOLFIRI With AG-013736 or Bevacizumab (Avastin) in Patients With Metastatic Colorectal Cancer After Failure Of One First Line Regimen

Last updated: April 12, 2013
Sponsor: Pfizer
Overall Status: Completed

Phase

2

Condition

N/A

Treatment

N/A

Clinical Study ID

NCT00615056
A4061034
  • Ages > 18
  • All Genders

Study Summary

The study is designed to demonstrate that the combination of AG-013736 with either FOLFIRI or FOLFOX is superior to FOLFIRI or FOLFOX in combination with bevacizumab (Avastin) in delaying tumor progression in the second-line treatment of patients with metastatic colorectal cancer after failure of an irinotecan or oxaliplatin-containing first-line regimen.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Histologically documented colorectal cancer plus one of the following:

  • Failure of one prior irinotecan- or oxaliplatin-containing regimen, or

  • Adjuvant refractory to irinotecan- or oxaliplatin-containing regimen.

Exclusion

Exclusion Criteria:

  • Prior treatment in first line metastatic setting with more than one regimen

  • Prior irradiation of more than 25% of bone marrow.

Study Design

Total Participants: 171
Study Start date:
March 01, 2008
Estimated Completion Date:
April 30, 2012

Connect with a study center

  • Pfizer Investigational Site

    Greenfield Park, Quebec J4V 2H1
    Canada

    Site Not Available

  • Pfizer Investigational Site

    Levis, Quebec G6V 3Z1
    Canada

    Site Not Available

  • Pfizer Investigational Site

    Montreal, Quebec H2X 3J4
    Canada

    Site Not Available

  • Pfizer Investigational Site

    Lille, 59020
    France

    Site Not Available

  • Pfizer Investigational Site

    Montpellier, 34094
    France

    Site Not Available

  • Pfizer Investigational Site

    Paris, 75012
    France

    Site Not Available

  • Pfizer Investigational Site

    Villejuif, 94805
    France

    Site Not Available

  • Pfizer Investigational Site

    Genova, 16132
    Italy

    Site Not Available

  • Pfizer Investigational Site

    Padova, 35128
    Italy

    Site Not Available

  • Pfizer Investigational Site

    Roma, 00168
    Italy

    Site Not Available

  • Pfizer Investigational Site

    Kashiwa, Chiba
    Japan

    Site Not Available

  • Pfizer Investigational Site

    Suntougun, Shizuoka
    Japan

    Site Not Available

  • Pfizer Investigational Site

    Chuo-ku, Tokyo
    Japan

    Site Not Available

  • Pfizer Investigational Site

    Daegu, 700-721
    Korea, Republic of

    Site Not Available

  • Pfizer Investigational Site

    Jeollanam-do, 519-809
    Korea, Republic of

    Site Not Available

  • Pfizer Investigational Site

    Seoul, 139-706
    Korea, Republic of

    Site Not Available

  • Pfizer Investigational Site

    Warszawa, 02-781
    Poland

    Site Not Available

  • Pfizer Investigational Site

    L'hospitalet de Llobregat, Barcelona 08907
    Spain

    Site Not Available

  • Pfizer Investigational Site

    Sabadell, Barcelona 08208
    Spain

    Site Not Available

  • Pfizer Investigational Site

    Madrid, 28033
    Spain

    Site Not Available

  • Pfizer Investigational Site

    Mobile, Alabama 36608
    United States

    Site Not Available

  • Pfizer Investigational Site

    Antioch, California 94531
    United States

    Site Not Available

  • Pfizer Investigational Site

    Los Angeles, California 90095
    United States

    Site Not Available

  • Pfizer Investigational Site

    Pleasant Hill, California 94523
    United States

    Site Not Available

  • Pfizer Investigational Site

    San Leandro, California 94578
    United States

    Site Not Available

  • Pfizer Investigational Site

    Santa Monica, California 90404
    United States

    Site Not Available

  • Pfizer Investigational Site

    Aurora, Colorado 80045
    United States

    Site Not Available

  • Pfizer Investigational Site

    Bonita Springs, Florida 34135
    United States

    Site Not Available

  • Pfizer Investigational Site

    Bradenton, Florida 34209
    United States

    Site Not Available

  • Pfizer Investigational Site

    Cape Coral, Florida 33914
    United States

    Site Not Available

  • Pfizer Investigational Site

    Englewood, Florida 34223
    United States

    Site Not Available

  • Pfizer Investigational Site

    Fort Myers, Florida 33905
    United States

    Site Not Available

  • Pfizer Investigational Site

    Naples, Florida 34119
    United States

    Site Not Available

  • Pfizer Investigational Site

    Port Charlotte, Florida 33980
    United States

    Site Not Available

  • Pfizer Investigational Site

    Sarasota, Florida 34236
    United States

    Site Not Available

  • Pfizer Investigational Site

    Venice, Florida 34285
    United States

    Site Not Available

  • Pfizer Investigational Site

    Atlanta, Georgia 30318
    United States

    Site Not Available

  • Pfizer Investigational Site

    Ringgold, Georgia 30736
    United States

    Site Not Available

  • Pfizer Investigational Site

    Dubuque, Iowa 52001
    United States

    Site Not Available

  • Pfizer Investigational Site

    Crestview Hills, Kentucky 41017
    United States

    Site Not Available

  • Pfizer Investigational Site

    Paducah, Kentucky 42002
    United States

    Site Not Available

  • Pfizer Investigational Site

    Baltimore, Maryland 21237
    United States

    Site Not Available

  • Pfizer Investigational Site

    New Albany, Mississippi 38652
    United States

    Site Not Available

  • Pfizer Investigational Site

    Oxford, Mississippi 38655
    United States

    Site Not Available

  • Pfizer Investigational Site

    Cincinnati, Ohio 45248
    United States

    Site Not Available

  • Pfizer Investigational Site

    Fairfield, Ohio 45014
    United States

    Site Not Available

  • Pfizer Investigational Site

    Hamilton, Ohio 45013
    United States

    Site Not Available

  • Pfizer Investigational Site

    Chattanooga, Tennessee 37404
    United States

    Site Not Available

  • Pfizer Investigational Site

    Franklin, Tennessee 37067
    United States

    Site Not Available

  • Pfizer Investigational Site

    Gallatin, Tennessee 37066
    United States

    Site Not Available

  • Pfizer Investigational Site

    Germantown, Tennessee 38138
    United States

    Site Not Available

  • Pfizer Investigational Site

    Hermitage, Tennessee 37076
    United States

    Site Not Available

  • Pfizer Investigational Site

    Hixson, Tennessee 37343
    United States

    Site Not Available

  • Pfizer Investigational Site

    Lebanon, Tennessee 37087
    United States

    Site Not Available

  • Pfizer Investigational Site

    Murfreesboro, Tennessee 37130
    United States

    Site Not Available

  • Pfizer Investigational Site

    Nashville, Tennessee 37205
    United States

    Site Not Available

  • Pfizer Investigational Site

    Paris, Tennessee 38242
    United States

    Site Not Available

  • Pfizer Investigational Site

    Smyrna, Tennessee 37167
    United States

    Site Not Available

  • Pfizer Investigational Site

    Union City, Tennessee 38261
    United States

    Site Not Available

  • Pfizer Investigational Site

    Corpus Christi, Texas 78463
    United States

    Site Not Available

  • Pfizer Investigational Site

    Mechanicsville, Virginia 23116
    United States

    Site Not Available

  • Pfizer Investigational Site

    Midlothian, Virginia 23114
    United States

    Site Not Available

  • Pfizer Investigational Site

    Richmond, Virginia 23235
    United States

    Site Not Available

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