Proton Radiotherapy With Chemotherapy for Nasopharyngeal Carcinoma

Phase

Condition

Nasopharyngeal Cancer

Carcinoma

Treatment

N/A

Clinical Study ID

NCT00592501

05-089

Ages > 18
All Genders

Study Summary

Photon beam radiation is the standard type of radiation used to treat nasopharyngeal carcinoma. Photon beam radiation enters the body and passes through healthy tissue, encounters the tumor and leaves the body through healthy tissue. Proton beam radiation has been shown to have the same effect on tumors as photon beam radiation but it enters the body, passes through healthy tissue, and encounters the tumor but then stops. This means less healthy tissue is affected by proton beam treatment than by photon beam treatment. The purpose of this study is to determine the effectiveness of proton beam radiation in treating nasopharyngeal cancer and reducing the acute and long-term side effects from the treatment. This study will also test to see if the sparing of the healthy tissue can improve quality of life

Eligibility Criteria

Inclusion

Inclusion Criteria:

Biopsy proven greater than or equal to T2b and/or node positive non-metastatic,squamous cell carcinoma of the nasopharynx, types WHO I-III.
No head and neck surgery of the primary tumor or lymph nodes except incisional orexcisional biopsies.
Zubrod performance status 0-1 or Karnofsky 70 or above.
All patients must undergo pre-treatment evaluation of tumor extent and tumormeasurement.
Nutritional and general physical condition must be considered compatible with theproposed chemoradiation treatment
Patients must have adequate platelet and renal function as outlined in protocol.
18 years of age or above.
No active alcohol addiction.
Women of childbearing potential must have a negative pregnancy test.

Exclusion

Exclusion Criteria:

Stage IVC or evidence of distant metastases
Previous irradiation for head and neck tumor
Patient is on other experimental therapeutic cancer treatment
Other malignancy except non-melanoma skin cancer or carcinomas of head and neck originand have been controlled for at least 5 years.
Active untreated infection
Major medical or psychiatric illness
Prophylactic use of amifostine or pilocarpine
Pregnant or breast feeding women
Symptomatic peripheral neuropathy of grade 2 or greater by NCI CTCAE
Symptomatic altered hearing > grade 2 by CTCAE

Study Design

October 01, 2006

April 30, 2019

Study Description

Before beginning study treatment, participants will be asked to fill out a Quality of Life (QOL) questionnaires, a Speech Assessment, a ChemoSensory Questionnaire, a Patient Swallowing Diary, A Swallowing Study, Salivary Tests and a Trismus Assessment. Participants will need to go to the Massachusetts Eye and Ear Infirmary (MEEI) or Massachusetts General Hospital (MGH) for these tests.
Radiation therapy will be given once a day, five days a week, for seven weeks. This will be given as outpatient care at the Northeast Proton Therapy Center (proton component) and Massachusetts General Hospital (photon component).
During radiation treatments, participants will receive cisplatin intravenously once every three weeks. This three-week period is called a cycle of treatment.
After the completion of radiation, participants will receive cisplatin intravenously once every 4 weeks along with fluorouracil as a continuous infusion over 4 days starting on the day cisplatin is given, for three cycles.
Participants will have a physical exam and blood work drawn weekly to monitor their health.
An MR/CT scan of the head and neck will be done 2 months after the radiation treatment.
Follow-up visits will occur once every three months for 2 years, then once every 6 months during years 3-5, then annually. During these follow-up visits, participants will have the following tests and procedures: physical examination; blood work; chest CT scan and CT/MRI of the head and neck will be repeated once every 6 months during the first three years; swallow study; salivary study; QOL questionnaires; speech assessment; ChemoSensory Questionnaire; and Trismus Assessment.

Connect with a study center

Dana-Farber Cancer Institute
Boston, Massachusetts 02115
United States
Site Not Available
Massachusetts General Hospital
Boston, Massachusetts 02114
United States
Site Not Available

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