Ascertainment of Families for Genetic Studies of Familial Lymphoproliferative Disorders

Inclusion Criteria:

• Individuals with a personal and/or family history of lymphoma or lymphoproliferativedisease B-cell malignancies, or multiple myeloma referred for study participation,or MSK patients referred from to the MSKCC outpatient clinics of the Lymphoma,Multiple Myeloma, or Leukemia Services in the Department of Medicine in consultationfor treatment who are found on routine history or through a Family HistoryQuestionnaire (FHQ) (Appendix A). Individuals who have relatives or members ofsuccessive generations of the family affected with Hodgkin's disease, non-Hodgkin'slymphoma, lymphoid leukemia, multiple myeloma other lymphoproliferative diseaseprostate or pancreatic cancers, or other conditions suggesting hereditary cancer atthe discretion of the MSKCC Principal Investigator. Patients with lymphoma,associated with colon and renal cancer will be eligible for DNA storage through thisprotocol. Family members or probands with Hodgkin's disease who are women whoreceived therapeutic irradiation for Hodgkin's disease" or who developed secondarycancers after Hodgkin's disease are also eligible for participation.

• The criteria for eligibility are broad because the ascertainment by the computerizedFHQ does not allow for resolution of different types of lymphoma or different typesof leukemia. Patient recall of this information is also imprecise. More accuratefamily history information will be obtained upon contact of family members anddiagnoses will be verified by obtaining pathologic documentation. The spectrum offamilial lymphoproliferative syndromes (LPS) may include all types of lymphoma aswell as chronic lymphocytic leukemia. This is an additional reason to have a broadeligibility. Subset analysis will be performed on specific types of lymphoidneoplasms. DNA of patients with a family history of lymphoma who have consented toprotocol 93-102 ("Ascertainment of Peripheral Blood or Saliva Samples for GeneticEpidemiology Studies of Familial Cancers") will also be eligible for inclusion inthis study.

• Family members of probands including patients, sisters, brothers, halfbrothers andsisters, sons, daughters, grandparents, as well as aunts and uncles are alsoeligible. An effort will be made to ascertain all living affected and unaffectedliving relatives in the affected lineage. An emphasis will be on affected siblingpairs and both parents, if alive.

• As this study involves research that presents no greater than minimal risk tochildren (see Sec. 46.404 of Federal Regulations part 46), minors are also eligiblefor participation. The assent of any minor should be obtained before the patient isenrolled into this study, as well as the consent of the legal guardian.

Exclusion Criteria:

• N/A